Ongoing Grants/Projects

Dominic Borgialli, DO

Great Lakes Emergency Medical Services for Children Research Network
The purpose of the EMSC-NDDP cooperative agreement is to continue to demonstrate the value of an infrastructure or network designed to be the platform from which to conduct investigations on the efficacy of treatments, transport, and care responses including those preceding the arrival of children to the hospital emergency departments.
Role: Co-Investigator
Health Resources and Service Administration
2 U03 MC 00003-05

Rebecca M. Cunningham, MD

International Collaborative Alcohol & Injury Research Training Program in Poland
A multi-tiered research training program will be established through collaboration among researchers at UM and Wroclaw Medical University (WMU) and several other academic medical settings in Poland. This builds on a successful training and research collaboration between UM and Polish scientists at the Institute of Neurology and Psychiatry and the Medical Collage of Warsaw focused on substance use disorders. This new specific injury and alcohol collaboration brings together expertise in alcohol-related injury prevention, EMS/Trauma services, psychiatry, public health and transportation research at UM with a developing expertise in injury and trauma medicine and public health at WMU in order to increase training and research capacity in Poland. A consortium at WMU and academic medical and public health locations throughout Poland will be fostered through this collaborative effort. The program will train visiting Polish scientists at the UM in alcohol and injury research methodology, and develop mentored programs of research that address current issues in alcohol and injury prevention, treatment, and evaluation in Poland.
Role: Core Faculty Member.
PAR-04-083 (Blow F)
NIAAA /NIH

Tailored Teen Alcohol and Violence prevention in the ER
Develop and refine a tailored integrated prevention approach with different delivery mechanisms (Computer adapted motivational interviewing / skills training and Therapist adapted motivational interviewing / skills training interventions), that address both alcohol misuse and violence among adolescents ages 14-18 seeking care in an urban ED. Conduct a randomized controlled trial comparing the effectiveness of integrated tailored alcohol and violence prevention approaches with 3-, 6-, and 12-month outcomes. Examine the influence of key moderating variables (e.g., demographic and treatment process) and proximal outcome variables on intervention effectiveness.
Role: Co-PI
1 R01 AA014889-01A1 (Walton M)
NIAAA

Cocaine & Chest Pain in the ED: Services and Outcomes
The specific aims of the study, are: 1) To develop a comprehensive portrait of a consecutive cohort of cocaine users presenting to the ED with chest pain, including socio-demographic characteristics, current and past route of administration and drug use history, DSM-IV substance use diagnoses, drug treatment history, past and present criminal justice involvement, co-occurring psychological distress, other medical complications of cocaine use including injury and interpersonal violence, and health status. 2) To identify specific locations where study participants interact with the health service system in the year following their ED visit and to identify the key patient characteristics associated with types of service use. Services will include drug treatment, linkages to primary care following the index ED visit, as well as patterns of service use. 3) To identify access barriers to engaging in treatment and use of other services including primary care. 4) To measure one-year outcomes for this cohort and to identify key socio-demographic and clinical characteristics of cocaine-using individuals associated with outcomes in the year after their ED visit for chest pain. 5) To identify the timing, service setting, and provisional type of future interventions, based on findings from Specific Aims 1-4 and qualitative date.
Role: Co-Investigator
R-01-DA14343-01 (Booth)
National Institute on Drug Abuse (NIDA), (NIH)

Interventions for Injured ED Substance Abusers
The proposed five year study will screen patients presenting to an inner city Emergency Department for drug abuse/dependence. Those who meet criteria will be randomized into one of three drug abuse/dependence interventions: 1) a 5-session Strengths-Based Case Management (SBCM) model; 2) a 2-session Brief Motivational Enhancement (BME); or 3) a one-time Brief Informational Feedback (BIF) session. The interventions promote linkage to substance abuse assessment, referral, and treatment.
Role: Co-Investigator
1R01 DA016591 (Blow)
National Institute on Drug Abuse Services

Services Interventions for Injured ED Problem Drinkers
This proposed study will compare three alternative interventions in the ED to promote linkage and engagement in treatment for injured patients with alcohol abuse/dependence and has three specific conditions: 1) a 5-session Strengths-Based Case Management (SBCM) model; 2) a 2-session Motivational Enhancement Therapy (MET), or 3) a one-time Brief Informational Feedback (BIF) session. Patients who present to a large inner-city ED with injuries will be screened using a structured survey about alcohol use and consequences.
Role: Co-Investigator
1R01 AA014665-01A1 (Blow)
National Institute on Alcohol Abuse and Alcoholism

Peter F. Ehrlich, MD

Maternal Child Health. EMSC – NDDP Program
Objective - To improve access and treatment of emergency services for children. To be part of a network that conducts controlled trials for emergency issues for children.
Role: Consultant
1U03 MC 00003-01
Pediatric Emergency Care Applied Research Network.

Novel Approaches to Pediatric Injury Prevention
Objective - a. Refine and test the feasibility of a novel secondary injury prevention tool that increases seatbelt use by parents and children as well as to increase the number of children less than 12 years of age properly positioned in the back seat when riding in a car.
b. Use the data as building blocks to obtain peer reviewed funding for a randomized control trial (RCT) of this injury prevention tool.
Role: Principal Investigator
American Pediatric Surgery Foundation Scholarship

Terry Kowalenko, MD

MCEP Emergency Medicine Musculoskeletal Radiograph CD
Role: Content Editor

MCEP Emergency Medicine Ultrasound CD
Role: Co-Editor

Physician Survey on Knowledge of Spinal Cord Injury Management
Role: Principal Investigator

ED Workplace Violence
Role: Principle Investigator

Ronald F. Maio, DO, MS

Emergency Medical Services for Children (EMSC)
Great Lakes Regional Node for Pediatric EMS Research
This is a project to develop an infrastructure to conduct clinical research in emergency pediatric care. University of Michigan is one of four centers, nationwide, that is involved in this network. His primary role is to oversee the development of this infrastructure as well as develop and implement pilot studies.
Role: Principal Investigator
Department of Health and Human Services, Maternal and Child Health Bureau 2 U03MC00003-05

Childhood Head Trauma: Neuro-Imaging Decision Rule,
PECARN grant
Site PI (Nathan Kuppermann, UC Davis is Project PI)
Subcontract UC Davis (Primary Funding Agency MCHB)
F010303 (Maio)

Nonhospitalized TBI: Michigan Incidence, Impact and Cost
The primary goal of this project is to determine the frequency of post concussive syndrome (PCS) associated with mild traumatic brain injury (MTBI). Dr. Maio is the PI of the study and has the full responsibility for overseeing the project.
Role: Principal Investigator
Department of Health and Human Services, Public Health Services, Centers for Disease Control
R49/CCR523223-01

Emergency Medical Services Cost Analysis Project
The overall goal of this project is to integrate the discipline of economic evaluation into the field of EMS research. The first two years of this project had the following objectives:
Objective 1: Synthesize the state of the art/science of economic evaluation and its relevance to EMS research by completing a systematic review of literature in regard to EMS economic evaluation studies. Objective 2: Develop a conceptual framework for applying cost analysis in EMS research.
Role on Project: PI
National Association of State EMS Directors
F014119

Mark R. Sochor, MD

Traumautopsy
Utilization of post-mortem computed tomography to evaluate fatal injury mechanisms.
Role: Principal Investigator
Department of Emergency Medicine
University of Michigan

Biomechanical Research Support
Impact trauma research to evaluate the principles of mechanics to discover the physical response and physiological results of impacts to the human body.
Role: Co-PI
National Highway Transportation and Safety Administration (NHTSA)
Cooperative Agreement DTNH22-05-H-01020

James M. Pribble, MD

Analysis of how unintentional injury is reported on local TV
This project studies how the television news media reports injury and how this information can impact public perceptions and the policy agenda regarding injury prevention.
Role: Principal Investigator
Center for Disease Control and Prevention
Injury Research Center at Medical College of Wisconsin

Rachel Stanley, MD

Great Lakes Emergency Medical Services for Children Research Network
The purpose of the EMSC-NDDP cooperative agreement is to continue to demonstrate the value of an infrastructure or network designed to be the platform from which to conduct investigations on the efficacy of treatments, transport, and care responses including those preceding the arrival of children to the hospital emergency departments.
Role: Co-Investigator
Health Resources and Service Administration
2 U03 MC 00003-05

Childhood Head Trauma: A Neuroimaging Decision Rule
Goal: to derive a decision rule for identifying children at low and high risk of traumatic brain injury after head trauma.
Role: Co-investigator
Maternal and Child Health Bureau
R40MC02461-01-00

Tailored Teen Alcohol and Violence prevention in the ER
Develop and refine a tailored integrated prevention approach with different delivery mechanisms (Computer adapted motivational interviewing / skills training (AMI+ST) and Therapist adapted motivational interviewing / skills training (AMI+ST) interventions), that address both alcohol misuse and violence among adolescents ages 14-18 seeking care in an urban ED.
Role: Co-investigator.
National Institute on Alcohol Abuse and Alcoholism
1 R01 AA014889-01A1

BPCA Pediatric Off-Patent Drug Studies (PODS) Center – A randomized controlled trial of lorazepam versus diazepam for status epilepticus in children
To meet the needs of the FDA under the Best Pharmaceuticals for Children Act, the objective of this study is to obtain FDA approval for pediatric lorazepam dosing. This study has two components: 1) the first part of this study aims to determine the pharmacokinetics and optimal dosing of lorazepam in children with status epilepticus; 2) The second part of this study will establish the satefy and efficacy of initial therapies for children with status epilepticus, using a randomized controlled trial comparing lorazepam with diazepam.
Role: Co-investigator and site Principal Investigator
National Institute of Child Health and Human Development/NIH
HHS N01-HD-3393

Recently Completed Grants/Projects

Rebecca M. Cunningham, MD

Flint Youth Violence Prevention Center
Pilot Project: Brief Emergency Department Intervention (Maio, R. PI)
The specific aims of the Center are to: 1) build the scientific infrastructure to support the development of community-wide youth violence prevention interventions; 2) promote interdisciplinary strategies that foster collaboration; 3) work with community members to address youth violence prevention; 4) institutionalize violence prevention in health provider practice and training; and 5) develop an evaluation plan and surveillance system to monitor progress. The pilot project will adapt an existing alcohol related intervention in the Emergency Department for youth violence prevention. The web-based intervention will be designed to include an interactive component addressing violence prevention. The web-site program content will be based on risk and resiliency factors associated with violence and will include connections between alcohol use and violence, as well as violence not associated with alcohol use.
Role: Co-Investigator
R-49-CCR-518605-01 (Zimmerman)
Centers for Disease Control, Injury Control Center

Emergency Medicine National Alcohol Screening Day Alcohol Education Project
The purpose of this research study is to determine the effectiveness of Emergency Department Physicians in giving brief counseling on alcohol misuse to patients seen in the Emergency Department. Approximately 1000 patients from all 14 sites will be involved in the study. At three and six months following their ED visits, patients in both the treatment and control conditions will complete follow-up interviews by telephone using Interactive Voice Response (IVR) technology. Study aims include: the promotion of the adoption of screening, brief intervention and referral to treatment for alcohol abuse (SBIRT) among emergency department (ED) providers in accordance with the Healthy People 2010 objective 26-22, and thus improve the health of ED patients with alcohol use disorders.
Role: Co-Investigator
1 R03 AA015111-01 (Bernstein)
National Institute on Alcohol Abuse and Alcoholism (NIH)
National Alcohol Screening Day Emergency Department Study

Peter F. Ehrlich, MD

Maternal Child Health. EMSC – NDDP Program
Objective To improve access and treatment of emergency services for children. To be part of a network that conducts controlled trials for emergency issues for children.
Role: Co-Investigator
1U03 MC 00003-01
Pediatric Emergency Care Applied Research Network.

Terry Kowalenko, MD

ED Violence
Role: Co-Principal Investigator
American College of Emergency Medicine
Physicians Michigan Chapter Grant

The Efficacy Trial of Diaspirin Cross-Linked Hemoglobin (DCLHbTM) in the Treatment of Severe Hemorrhagic Shock
Role: Site Principal Investigator
Baxter HealthCare Corporation

Mark R. Sochor, MD

Assessment of 3- and 6-Year Old Neck Injury Criteria
Modeling of real-world crash utilizing Mathematical Dynamic Models (MADYMO) modeling and impact sled testing.
Role: Principal Investigator
TRW Automotive

James M. Pribble, MD

Local Television Health News: What are they talking about?
Largest study to date of broadcast news reporting of health information. Specifically, content analysis of top 50 local television news markets in the United States to determine what health topics were reported and the nature of the reporting.
Role: Principal Investigator (As research Fellow)
Robert Wood Johnson Clinical Scholars Program / VA

Rachel Stanley, MD

Use of the ED for non urgent care by children at selected Michigan EDs
Research funded to investigate use of the ED for non-urgent care by children in Michigan before and after Medicaid managed care.
Role: Co-investigator
Michigan Department of Community Health

BPCA Pediatric Off-Patent Drug Studies (PODS) Center – Lorazepam – Status Epilepticus
This is a pharmacokinetic study of lorazepam in children with status epilepticus.
Role: Co-investigator and site Principal Investigator
National Institute of Child Health and Human Development
HHSN2752004043393C/ABD N01-HD-3393