Ongoing Grants/Projects
Ongoing Grants/Projects
Dominic Borgialli, DO, MPH
Pediatric Emergency Care Applied Research Network (PECARN)
The purpose of the EMSC-NDDP cooperative agreement is to continue to demonstrate the value of an infrastructure or network designed to be the platform from which to conduct investigations on the efficacy of treatments, transport, and care responses including those preceding the arrival of children to the hospital emergency departments.
Role: Co-Investigator/ Hospital Emergency Department Affiliate (HEDA) Director
Funding: Emergency Services for Children (EMSC) program/Maternal and Child Health Bureau (MCHB)/Health Resources and Services Administration (HRSA)
Sponsor: Great Lakes Emergency Medical Services for Children Research Node/
U03 MC 00003-08 (PI: RM Stanley)
Clinical Decision Rules to Detect Children with Blunt Traumatic Intra-abdominal Injuries
Role: Nodal Champion
Funding: Centers for Disease Control and Prevention
Sponsor: Great Lakes Emergency Medical Services for Children Research Node/Pediatric Emergency Care Applied Research Network (PECARN)
(PI: J. Holmes)
Rebecca M. Cunningham, MD
Optimizing Alcohol SBIRT for Adolescents in the ED
The study will use computerized screening (~5,700 patients) and will test developmentally appropriate, tailored intervention strategies in a two-factorial design (3x2) using 900 patients aged 14-20 in the ED who screen positive for problematic alcohol use.
Role: Principal Investigator (PI: Cunningham/Walton)
National Institute on Alcohol Abuse and Alcoholism (R01)
Substance Use and Violent Injury among Youth in an Urban ED- Services & Outcomes
Specific aims are: (1) To describe characteristics of youth (ages 14-24) who report illicit drug use presenting to an urban ED for an acute violent injury; (2) To identify the trajectories of participants’ interactions with health services during the two years following their ED visit and the key characteristics associated with types of service use (substance use treatment; mental health; medical/ ED) and barriers to these services; (3) To measure two-year outcomes for this cohort and to identify key socio-demographic and clinical characteristics of youth with drug use, who have poor outcomes in the two years after ED visit for intentional injury and other medical care.
Role: Principal Investigator
National Institute on Drug Abuse
Optimizing SBIRT for Drug-Using Patients in an Inner-City Emergency Department
Role: Co-Investigator (PI: Blow)
National Institute on Drug Abuse
Adolescent Emergency Patients: Suicide Risk Detection and Treatment Facilitation
Specific aims are: (1) to develop TOC materials (intervention manual; culturally tailored Services Information and Decision Aid; therapist training and fidelity assessment procedures); (2) to conduct a feasibility pilot study; and (3) to conduct a pilot randomized controlled trial comparing TOC to enhanced treatment-as-usual.
Role: Co-Investigator (PI: King)
National Institute of Mental Health
Fogarty International Collaborative Trauma and Injury Research Training Program
International Collaborative Alcohol & Injury Research Training Program in Poland
Role: Co-Investigator (PI: Blow F)
NIAAA /NIH
Tailored Teen Alcohol and Violence prevention in the ER
This study will refine promising intervention approaches to incorporate computer tailoring technology based on assessment of the adolescents’ personal risk behaviors to address both alcohol misuse and violent behaviors, screening ~3000 adolescents in the ED (ages 14- 18) over 30 months.
Role: Co-Investigator (PI: Walton M)
NIAAA
Seat Belt Brief intervention. Mechanism Underlying Risk Assessment
Role: Co-Investigator (PI: Ehrlich)
University of Michigan Transportation Research Institute - NHTSA sub-grant
Peter F. Ehrlich, MD
Optimizing brief alcohol intervention for underage drinkers in the ED.
Role: Co I
1R01AA018122-01 (PI: Walton) 6/2009-5/2014
Treatment for Patients with Bilateral, Multicentric, or Bilaterally-Predisposed Unilateral Wilms Tumor. A phase III study.
Role: PI
U10CA0908543 NIH 7/2009- 7/2013
Children Oncology Group Intermediate Hodgkin’s Lymphoma Study.
Objective: a. Develop strategies to reduce cancer in children. b. Use the data as building blocks to obtain peer reviewed funding for a randomized control trial (RCT) of this injury prevention tool.
Role: Ehrlich (Surgical PI)
NCI (AHOD0031) 2/2001-2/2012
Children’s Oncology Group Grant
Intermediate Risk Hodgkin’s Lymphoma ADOOD3.
Lymphocyte Predominate Hodgkin’s Lymphoma- Surgery Only AHOD03P1.
AREN03B2 Renal (Wilms) tumors classification and banking study.
ARENO532 Renal tumors low risk study.
ARENO 533 Wilms tumor higher risk.
ARENO 534 Bilateral WT study.
ARENO 321 High risk WT study.
Role: Study Chair
Treatment for Patients with Bilateral, Multicentric, or Bilaterally-Predisposed Unilateral Wilms Tumor.
Role: Ehrlich (Surgical PI)
U10CA0908543 NIH 2/2003-2/2012
A Clinical Decision Rule to Identify Children with Intra-abdominal Injuries.
Study in use of nominal CT’s in injured children, a clinical decision rule as to when to use them and when not to.
Role: Consultant
1 R49 CE001002 (PI : Holmes) 9/01/06 - 8/31/09
International Collaborative Alcohol and Injury Research Training Program in Poland
This program will train visiting Polish scientists at the UM in alcohol and injury research methodology, and develop mentored programs of research that address current issues in alcohol and injury prevention, treatment, and evaluation in Poland.
Role: Consultant
National Institutes of Health, Fogarty International Center (PI: Blow) 4/01/06-2/28/11
Development of a novel objective measure to monitor bicycle helmet use in children.
Pilot program to monitor and measure bicycle helmet use in children.
Role: PI (15,000)
Office of the Vice Provost for Research University of Michigan 4/2007- 4/2009
Alcohol and Injury and Adolescents. A Computer-based Intervention
Role: PI
NIH/NCRR 1 U54 RR023422-01 09/2007 – 08/2009
A brief tailored family- centered seatbelt intervention for hospitalized trauma patients
Role: PI
UMTRI and NHTSA 11/2008-11/2009
Measurement of Maximum Hand- Rail and Hand -Rung Coupling Forces in Children. Effects of age and gender
Role: PI
Bone and Joint Injury Prevention and Rehabilitation 1/1/2009-1/12010
Jolie Holschen, MD
Correlation between the menstrual cycle and ligamentous ankle injury in women.
Department of Orthopaedic Surgery, The University of Michigan
Role: PI
The Sports Medicine Core Curriculum Lecture Series (Teaching Grant)
Ten lectures on medical illness and musculoskeletal injuries afflicting athletic individuals, designed for web based self teaching by emergency physicians and residents.
American College of Emergency Physicians (Sports Medicine Section)
Role: Project Coordinator
Gender Differences in Neuropsychologic Parameters, Risk of Sustaining Concussion, and Recovery after Mild Traumatic Brain Injury
Wilpon Sports Injury Prevention Center Pilot Grants, University of Michigan
Role: PI
Terry Kowalenko, MD
A Multi-site Intervention to Reduce Violence in Hospital Emergency Departments
Role: Co-Investigator (Site-Director) (PI: Donna Gates, RN, BSN, PhD (University of Cincinnati) Centers for Disease Control/National Institutes of Health (CDC/NIOSH)
James M. Pribble, MD
School Violence in the Media
The goal of this project is to expand on NCIPC’s knowledge of how school violence in portrayed in local news broadcasts and what the media says about prevention of violence in the school setting. With this new information, existing NCIPC materials will be revised and new documents for dissemination among school leaders and communication professionals will be developed. A dissemination plan targeting the individuals that are most influential before, during, and after a violent incident in the school setting will also be created.
Role: Sub-contractor
National Center for Injury Prevention and Control (NCIPC) at the Centers for Disease Control and Prevention (CDC)
Using the news media to disseminate booster seat information to the American public: How Police interact with the media and how can we improve it.
This proposed study will attempt to codify the process of police interaction with the local news media following motor vehicle crashes with specific attention being paid to the issue of booster seat usage. This will then lead to an understanding of the perceptions and beliefs of police officers regarding their potential role as media spokespeople for prevention following an MVC and to develop a web-based tool that may facilitate the interaction between police and the local news media.
Role: Principal Investigator
University of Michigan Transportation Research Institute
Alexander J. Rogers, MD
Pediatric Emergency Care Applied Research Network (PECARN)
Great Lakes Emergency Medical Services for Children Research Network
Role: Hospital Emergency Department Affiliate (PI: RM Stanley)
PECARN study of C-spine injuries in children
Role: site PI
Jonathan D. Rupp, Ph.D.
Knee-Thigh-Hip Response and Injury in Frontal Crashes
Role: Principal Investigator/Project Director
National Highway Traffic Safety Administration
Abdomen Response and Injury in Frontal and Side Impact
Role: Principal Investigator/Project Director
National Highway Traffic Safety Administration
Upgrading Anthropometry of Child ATDs to Improve Belt Restraint Fit and Loading
Role: Principal Investigator/Project Director
National Highway Traffic Safety Administration
Pregnant Occupant Injury Research
Role: Principal Investigator/Project Director
National Highway Traffic Safety Administration
IV Catheter penetration testing
Role: Principal Investigator/Project Director
Becton Dickinson
Simulations to Characterize Variations in Lower Extremity Injury Potential with Knee Impact Location, Seat Fore-Aft Position, and Muscle Activation
Role: Principal Investigator
Johnson Controls Inc.
Continued Development of Methods for Appropriate Analysis of CIREN Data
Role: Co-Principal Investigator,
National Highway Traffic Safety Administration
Crash Injury Research and Engineering Network Zone Center
Role: Co-Principal Investigator
National Highway Traffic Safety Administration
Nicole S. Sroufe, M.D, M.P.H.
Gender Differences in Neuropsychologic Parameters, Risk of Sustaining Concussion, and Recovery after Mild Traumatic Brain Injury
Role: Co-Investigator
Wilpon Grant, Sports Injury Prevention Center
PI: Jolie Holschen, MD
Rachel Stanley, MD
Great Lakes Emergency Medical Services for Children Research Network
The purpose of the EMSC-NDDP cooperative agreement is to continue to demonstrate the value of an infrastructure or network designed to be the platform from which to conduct investigations on the efficacy of treatments, transport, and care responses including those preceding the arrival of children to the hospital emergency departments.
Role: PI
Health Resources and Service Administration
2 U03 MC 00003-08
BPCA Pediatric Off-Patent Drug Studies (PODS) Center – Lorazepam – Status Epilepticus
Role: Co-investigator and site PI
National Institute of Child Health and Human Development (NICHD) (Study 2)
Tailored Teen Alcohol and Violence prevention in the ER
Develop and refine a tailored integrated prevention approach with different delivery mechanisms (Computer adapted motivational interviewing / skills training (AMI+ST) and Therapist adapted motivational interviewing / skills training (AMI+ST) interventions), that address both alcohol misuse and violence among adolescents ages 14-18 seeking care in an urban ED.
Role: Co-investigator.
National Institute on Alcohol Abuse and Alcoholism
1 R01 AA014889-01A1 (PI: Walton, M)
Maureen Walton, MPH, PhD
Optimizing Alcohol SBIRT for Adolescents in the ED
The study will use computerized screening (~5,700 patients) and will test developmentally appropriate, tailored intervention strategies in a two-factorial design (3x2) using 900 patients aged 14-20 in the ED who screen positive for problematic alcohol use.
Role: Principal Investigator (PI: Cunningham/Walton)
National Institute on Alcohol Abuse and Alcoholism (R01)
Substance Use and Violent Injury among Youth in an Urban ED- Services & Outcomes
Specific aims are: (1) To describe characteristics of youth (ages 14-24) who report illicit drug use presenting to an urban ED for an acute violent injury; (2) To identify the trajectories of participants’ interactions with health services during the two years following their ED visit and the key characteristics associated with types of service use (substance use treatment; mental health; medical/ ED) and barriers to these services; (3) To measure two-year outcomes for this cohort and to identify key socio-demographic and clinical characteristics of youth with drug use, who have poor outcomes in the two years after ED visit for intentional injury and other medical care.
Role: Co- Investigator
National Institute on Drug Abuse
Optimizing SBIRT for Drug-Using Patients in an Inner-City Emergency Department
Role: Co-Investigator (PI: Blow)
National Institute on Drug Abuse
A brief tailored family- centered seatbelt intervention for hospitalized trauma patients
Role: Co-Investigator (PI: Ehrlich)
University of Michigan Transportation Research Institute - NHTSA sub-grant
Alcohol, Injury and Adolescents: A Computer Intervention
Role: Consultant
University of Michigan New Pilot and Collaborative Grant Program for Translational and Clinical Research
Age-Related Services and Outcomes After DUI Interventions
Role: Co-Investigator (PI: Blow)
National Institute on Alcohol Abuse and Alcoholism
Tailored Teen Alcohol and Violence prevention in the ER
This study will refine promising intervention approaches to incorporate computer tailoring technology based on assessment of the adolescents’ personal risk behaviors to address both alcohol misuse and violent behaviors, screening ~3000 adolescents in the ED (ages 14- 18) over 30 months.
Role: PI
NIAAA
Tailored Youth Drug Intervention in Primary Care
Role: Co-Investigator (PI: Blow)
National Institute on Drug Abuse
Tailored Web Progam to Reduce At-Risk College Drinking
Role: Co- Investigator (PI: Bingham)
National Institute on Alcohol Abuse and Alcoholism
Fogarty International Collaborative Trauma and Injury Research Training Program
International Collaborative Alcohol & Injury Research Training Program in Poland
Role: Core Faculty (PI: Blow F)
NIAAA /NIH
Adolescent Emergency Patients: Suicide Risk Detection and Treatment Facilitation
Specific aims are: (1) to develop TOC materials (intervention manual; culturally tailored Services Information and Decision Aid; therapist training and fidelity assessment procedures); (2) to conduct a feasibility pilot study; and (3) to conduct a pilot randomized controlled trial comparing TOC to enhanced treatment-as-usual.
Role: Co-Investigator (PI: King)
National Institute of Mental Health
Recently Completed Grants/Projects
Dominic Borgialli, DO, MPH
A Multi-center Study to Evaluate the Effect of an Educational Pain Management Program on Pre-hospital Providers’ Knowledge and Practice
Role: Site PI
Funding: Department of Health and Human Services/Health Research Science Administration/Emergency Medical Services for Children/ Targeted Issue Grant
1 H34MC08515-01-00 (PI: H Hennes)
Great Lakes Emergency Medical Services for Children Research Node
Pediatric Emergency Care Applied Research Network (PECARN)
The purpose of the EMSC-NDDP cooperative agreement is to continue to demonstrate the value of an infrastructure or network designed to be the platform from which to conduct investigations on the efficacy of treatments, transport, and care responses including those preceding the arrival of children to the hospital emergency departments.
Role: Hospital Emergency Department Affiliate (HEDA) Director/ Co-investigator
DHHS/MCHB/EMSC
2 U03 MC 00003-05 (PI: RF Maio)
An Epidemiological Study to Evaluate the Seasonality of Respiratory Syncytial Virus-Associated Lower Respiratory Tract Infections or Apnea in Infants in the Emergency Department
Role: Site PI
MedImmune, Inc.
Great Lakes Emergency Medical Services for Children Research Node
Pediatric Emergency Care Applied Research Network (PECARN).
Role: Hospital Emergency Department Affiliate (HEDA) Director
DHHS/MCHB/EMSC
U03 MC 00003 (PI: RF Maio)
Rebecca M. Cunningham, MD
Alcohol and Injury and Adolescents. A Computer-based Intervention
Role: Co-Investigator (PI: Ehrlich)
Michigan Institute for Clinical & Health Research (MICHR), University of Michigan
Services Interventions for Injured ED Problem Drinkers
Role: Co-Investigator (PI: Blow)
National Institute on Alcohol Abuse and Alcoholism
Services Interventions for Injured ED Substance Abusers
Role: Co-Investigator (PI: Blow)
National Institute on Drug Abuse
Integrated Care for Medicaid Consumers with Behavioral Health Care Needs
Role: Co-Investigator (PI: King/Neal)
State of Michigan, Department of Community Health
Injury Prevention Efforts at U.S. Trauma Centers: Alcohol Screening and Intervention Practices
Role: PI
ACEP Section Grant (Section of Trauma and Injury Prevention)
Peter F. Ehrlich, MD
Injury Control Training and Demonstration Center (ICTDC)
Role: Co- Investigator
Determining Outcome Predictors of Rural Pediatric Trauma Patients and Their Families Source:
Role: PI
John Brick Research Grant
Attitudes and Perceptions about Bicycle Helmet and Seat Restraint Use among Children and Adults in Monongalia County
Role: PI
West Virginia University Clinical Research Trials Grant
Screening and Brief Intervention for Adolescent Alcohol Abuse in the ED
Role: Co- Principle Investigator
John Brick Research Grant
Trauma Nurses Talk Tough Source: Community Based Initiative (State of West Virginia)
Role: Co- Investigator
Screening and Brief Intervention for University Students
Role: PI
West Virginia Research Development Grant
Terry Kowalenko, MD
ED Violence
This was an American College of Emergency Physicians Chapter Grant awarded to the Michigan College of Emergency Physicians to evaluate the prevalence of violence against Emergency Department Attendings and whether more education was desired by physicians.
Role: Co-Principal Investigator
American College of Emergency Medicine
Physicians Michigan Chapter Grant
The Efficacy Trial of Diaspirin Cross-Linked Hemoglobin (DCLHbTM) in the Treatment of Severe Hemorrhagic Shock
This grant was awarded to multiple sites involved in the multi-center study to assess the efficacy of this hemoglobin substitute in emergency treatment of hemorrhagic shock. The study was terminated prior to patient recruitment at Henry Ford Hospital.
Role: Site Principal Investigator
Baxter HealthCare Corporation
James M. Pribble, MD
Analysis of how unintentional injury is reported on local TV
This project studies how the television news media reports injury and how this information can impact public perceptions and the policy agenda regarding injury prevention.
Role: Principal Investigator
Center for Disease Control and Prevention
Injury Research Center at Medical College of Wisconsin
Local Television Health News: What are they talking about?
Largest study to date of broadcast news reporting of health information. Specifically, content analysis of top 50 local television news markets in the United States to determine what health topics were reported and the nature of the reporting.
Role: Principal Investigator (As research Fellow)
Robert Wood Johnson Clinical Scholars Program / VA
Alexander J. Rogers, MD
Analgesic Effect of Oral Sucrose
Children’s Research Oversight Committee
Role: Co-PI
Nicole Sroufe, M.D., M.P.H.
Pediatric Mild Head Injury: Definition and Consequences
Role: Co-Investigator/Study Coordinator
Centers for Disease Control and Prevention
National Center for Injury Prevention and Control
R49 CE000284-01 (PI: Ronald F. Maio, DO)
Rachel Stanley, MD
Great Lakes Emergency Medical Services for Children Research Network
The purpose of the EMSC-NDDP cooperative agreement is to continue to demonstrate the value of an infrastructure or network designed to be the platform from which to conduct investigations on the efficacy of treatments, transport, and care responses including those preceding the arrival of children to the hospital emergency departments.
Role: PI
Health Resources and Service Administration
2 U03 MC 00003-05
PECARN. Pediatric Applied Research Network.
The purpose of the EMSC-NDDP cooperative agreement is to continue to demonstrate the value of an infrastructure or network designed to be the platform from which to conduct investigations on the efficacy of treatments, transport, and care responses including those preceding the arrival of children to the hospital emergency departments.
Role: Site PI, 10%
Maternal and Child Health Bureau (MCHB)
4D1BTH00026-01-03 (PI: Maio, R)
Childhood Head Trauma: A Neuroimaging Decision Rule
Goal: to derive a decision rule for identifying children at low and high risk of traumatic brain injury after head trauma.
Role: Co-investigator.
Maternal and Child Health Bureau (MCHB)
R40MC02461-01-00 (PI: Kuppermann)
Pharmacokinetic study of Lorazepam in pediatric epileptics.
This is a pharmacokinetic study of lorazepam in children with epilepsy.
Role: Site PI
NICHD-2003-10 and FDA (PI: Chamberlain)
FDA (Study 1)
Maureen Walton, MD
Services Interventions for Injured ED Problem Drinkers
Role: Co-Investigator (PI: Blow)
National Institute on Alcohol Abuse and Alcoholism
Services Interventions for Injured ED Substance Abusers
Role: Co-Investigator (PI: Blow)
National Institute on Drug Abuse
The use of tailored brief intervention messages in the emergency department
Role: Co-Investgator
National Institute on Alcoholism and Alcohol Abuse (PI: Blow)
Flint Youth Violence Prevention Center
Pilot Project: Brief Emergency Department Intervention. The specific aims of the Center are to: 1) build the scientific infrastructure to support the development of community-wide youth violence prevention interventions; 2) promote interdisciplinary strategies that foster collaboration; 3) work with community members to address youth violence prevention; 4) institutionalize violence prevention in health provider practice and training; and 5) develop an evaluation plan and surveillance system to monitor progress. The pilot project will adapt an existing alcohol related intervention in the Emergency Department for youth violence prevention. The web-based intervention will be designed to include an interactive component addressing violence prevention. The web-site program content will be based on risk and resiliency factors associated with violence and will include connections between alcohol use and violence, as well as violence not associated with alcohol use.
Role: Co-Investigator
R-49-CCR-518605-01 (Zimmerman)
Centers for Disease Control, Injury Control Center
Cocaine & Chest Pain in the ED: Services and Outcomes
The specific aims of the study are: 1) To develop a comprehensive portrait of a consecutive cohort of cocaine users presenting to the ED with chest pain. 2. To identify specific locations where study participants interact with the health service system in the year following their ED visit and to identify the key patient characteristics associated with types of service use. 3. To identify access barriers to engaging in treatment and use of other services including primary care. 4. To measure one-year outcomes for this cohort and to identify key socio-demographic and clinical characteristics of cocaine-using individuals associated with outcomes in the year after their ED visit for chest pain.
Role: Co-Investigator
National Institute on Drug Abuse (NIDA) (NIH)
R-01-DA14343-01 (PI: Booth)
Developing Violence Therapy for Substance Abusers
Role: Co- Investigator
National Institute on Drug Abuse (PI: Chermack)
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