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Respiratory Laboratory 2:
Reading Assignments (Robbins: Pathologic Basis of Disease)
|8th Edition||7th Edition|
|683 - 687||716 - 721|
|687 - 693||722 - 728|
|699 - 701||735 - 737|
A 30-year old man had a severe shaking chill that lasted for an hour. Shortly afterwards, he developed a fever of 40.0 degrees centigrade, marked tachycardia, tachypnea, a dry cough, and right-sided pleuritic chest pain. His cough became productive of thick, tenacious, rust-colored sputum. He had been previously well. He presented for medical attention to his primary care physician.
He appeared ill and was in moderate respiratory distress. His respirations were shallow and there was increased tactile fremitus and dullness to percussion over the right hemithorax. Fever and tachypnea were present, as were bronchial breath sounds and crackles. Laboratory values included a leukocytosis with a left shift and an elevated sedimentation rate. Arterial blood gases revealed hypoxemia. A chest radiograph demonstrated opacification and air bronchograms of the right middle and lower lobes. Despite aggressive medical treatment, the patient died.
A 23-year old patient with severe prolonged neutropenia developed left-sided chest pain and fever and began coughing up blood. She became seriously ill over the next 24 hours and subsequently required ventilator support. A chest x-ray showed patchy densities; a CT scan revealed a mass-like infiltrate surrounded by an area of low attenuation. The patient died several days after becoming comatose.
A 74 year old woman presents with a large supraglottic squamous cell carcinoma, for which she undergoes radiation therapy followed by total laryngectomy. She is followed for recurrence by serial CT scans. A 1.2 cm right middle lobe lung nodule is discovered on one of these CT scans. She undergoes a wedge resection of the nodule in order to make a diagnosis.
A 60-year-old man sought medical attention because of weight loss. During his evaluation, the patient also complained of a decreased appetite, weakness, and night sweats. A non-productive cough had recently developed. Physical examination revealed hepatomegaly and splenomegaly. A chest radiograph manifested a diffuse reticulonodular infiltrate. Laboratory evaluation disclosed an anemia with leukopenia and an elevated alkaline phosphatase level. A liver biopsy sample was obtained and a diagnosis was established. The patient responded promptly to treatment. Slide 26 was obtained from a similar patient at autopsy.
A 43-year old woman was admitted to the hospital because of hemoptysis and dyspnea. The patient had been well until 28 months ago, a mammogram showed a speculated right breast mass. Fine needle aspiration of the mass was positive for malignancy. She underwent a right modified radical mastectomy which demonstrated a 1.2 cm invasive ductal carcinoma with metastases to one of thirteen axillary lymph nodes. The patient underwent post-op chemotherapy and radiation. Over the ensuing months, metastatic disease was detected in bones and in the liver. An infiltrate of the left lower lobe was also detected.
Physical examination manifested local dullness at the left lung base, with diminished breath sounds and inspiratory crackles; no egophonoy or wheezing was heard. Abdominal examination disclosed tenderness of both lower quadrants without guarding; the liver and spleen were not felt. There was no peripheral edema or digital clubbing. The urine was normal. A CBC revealed a while blood count of 6500 with 73% neutrophils. The platelet count was 478,000/mm3. A chest x-ray showed infiltrates in the left lower and right upper lobes, and a left-sided pleural effusion. A bronchoscopic biopsy was unsuccessful because of bleeding from the left upper lobe. A bronchoalveolar lavage specimen from this site disclosed a few acid fast bacilli. Multiple examinations of sputum specimens revealed no acid fast bacilli and cultures were negative for mycobacteria. The radiographic chest infiltrates rapidly progressed. An open lung biopsy sample was obtained.
The patient developed acute hypoxemia, persistent dyspnea, and respiratory failure. Empiric antibiotic therapy and 100% oxygen therapy did not bring about clinical improvement.
Your instructor will illustrate the open lung biopsy for you.
The answers to the path lab questions will be posted approximately 48-72 hours after the lab sessions. These are abbreviated answers, not a full discussion of the topics. You can find them in the M2 CTools site resources. In the folder for each sequence the will be a folder called 'Path Lab Resources'