|Path Labs||CTools||Lab Instructors||ImageScope||Histology Normals||Histology Site||M1 Histopathology|
Respiratory Laboratory 3:
Reading Assignments (Robbins: Pathologic Basis of Disease)
|8th Edition||7th Edition|
|723 - 727||759 - 762|
|729 - 730||764 - 765|
|732 - 734||768 - 770|
A 74 year old woman presents with a large supraglottic squamous cell carcinoma, for which she undergoes radiation therapy followed by total laryngectomy. She is followed for recurrence by serial CT scans. A 1.2 cm right middle lobe lung nodule is discovered on one of these CT scans. She undergoes a wedge resection of the nodule in order to make a diagnosis.
A 55-year old woman sought medical attention because of shortness of breath and left sided chest pain. Clinical evaluation revealed a left-sided pleural effusion that was tapped. A follow-up chest x-ray demonstrated a non-calcified mass in the periphery of the left upper lobe. A portion of the effusion was analyzed in the cytopathology laboratory where a diagnosis of malignancy was rendered. Based on this information, this patient was treated with chemotherapy. Following a short-lived response to therapy, the patient deteriorated and died 4 months later. The slide shows one of several histologic variations of this neoplasm.
A 60-year old man sought medical attention because of weight loss. During his evaluation, the patient also complained of a decreased appetite, weakness, and night sweats. A non-productive cough had recently developed. Physical examination revealed hepatosplenomegaly. A chest x-ray manifested a diffuse nodular infiltrate. Laboratory evaluation disclosed an anemia with leukopenia, and an elevated alkaline phosphatase level. A liver biopsy was obtained for diagnosis, and the patient responded well to treatment. The provided slide is taken from the autopsy of a similar patient.
During his evaluation for progressive proximal muscle weakness and fatigability, a lung nodule was detected in a 44-year-old man. The nodule was subsequently resected, and the muscle weakness gradually improved.
This lesion was resected from the lung of a 28-year old man who had complained of occasional hemoptysis. His health had otherwise been excellent and he was a nonsmoker. Based upon the pathologic features, how would you classify this neoplasm?
The answers to the path lab questions will be posted approximately 48-72 hours after the lab sessions. These are abbreviated answers, not a full discussion of the topics. You can find them in the M2 CTools site resources. In the folder for each sequence the will be a folder called 'Path Lab Resources'