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If working from a computer outside the University network, the links to virtual slides embedded in the PowerPoint document may not work. This page provides access to the virtual slides.
The Case descriptions, Questions and links to virtual slides are reproduced below. All other required content (photomicrographs, graphics, factual content, answers to questions) are in the PowerPoint documents.
For comparison, please refer to the following NORMAL smears:
History: 55-year-old female presents with increasing fatigue, night sweats, weight loss, and abdominal "fullness." The patient has marked splenomegaly, 10 cm below the left costal margin, without lymphadenopathy. The CBC showed: WBC = 105,000 cells/mm3, Hb = 10.5 gm/dl, and platelets = 85,000/mm3.
Compare the blood smear in this patient to the normal blood and bone marrow smears and answer the following questions.
Case 2: Peripheral blood stem cell disorders
History #1: 58-year-old male with increasing weakness, fatigue, malaise, unexplained lower extremity bruises and weight loss over the previous six weeks. Petechiae on exam. WBC = 155,000 cells/mm3, Hb = 9.0 gm/dl, platelets = 11,000/mm3.
History #2: Four-year-old female with a febrile pharyngitis and otitis, unresponsive to antibiotics. Increasing fatigue, malaise, and nondescript bone and joint pains. Conjunctival pallor and petechiae on her lower extremities. WBC = 55,000 cells/mm3, Hb = 7.6 gm/dl, platelets = 5,000/mm3.
Case 3: Peripheral blood lymphocytic disorder
Additional Test Results: Flow Cytometry
History: The patient is a healthy 65-year-old male who was noted to have slightly enlarged axillary and cervical lymph nodes on an annual physical examination. The patient offered no complaints and was given a "clean bill of health" one year previously. No organomegaly was noted. The CBC showed: WBC = 45,000 cells/mm3, Hb = 13.5 gm/d., platelets = 185,000/mm3. Compare the blood smear in this patient to the normal and abnormal smears from other cases.