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Hematopathology
LAB 1: Anemias and Leukocytoses

See Hematopathology Lab Introduction 2015 document for description of labs and expectations (on Website or available as PDF from download site).

Download the “Hematopathology Lab 1 2015 Anemias and Leukocytoses.ppt” and use as directed in Introduction. Remember to continue study of the “Hematology Atlas 2015.pptx” document from the first week.

If working from a computer outside the University network, the links to virtual slides embedded in the PowerPoint document may not work. This page provides access to the virtual slides.

The Case descriptions, Questions and links to virtual slides are reproduced below. All other required content (photomicrographs, graphics, factual content, answers to questions) are in the PowerPoint documents.

 

Refer to the following NORMAL BLOOD SMEAR for comparison:
[WebScope] [ImageScope]

Case 1:  RBC abnormalities

Blood smear: [WebScope] [ImageScope]

History: A 19-year-old woman with anemia presents with a two day history of fever and joint pain.  She reports experiencing similar episodes 2-3 times/year that respond to hydration and pain medication. Her history is notable for avascular necrosis of the left femoral head at age 14. Examine the virtual slide and answer the following questions.

  1. What are the major RBC abnormalities on the smear?

  2. A diagnosis of the "process" is readily made by inspection of the smear. What additional test(s) establish etiology?

  3. What would you expect the red cell indices to show in this case?

  4. If you just had the CBC and red blood cell indices, what other types of anemia would you consider?

  5. How do the morphologic and biochemical abnormalities produce symptoms, signs and complications in this disease?



Case 2:  RBC abnormalities

Blood smear: [WebScope] [ImageScope]

History: The patient is a 28-year-old woman in the second trimester of pregnancy. Her pregnancy has been uncomplicated but she tires easily and is short of breath from even the slightest exertion. Periods of light-headedness, though not to the point of fainting. Patient has tachycardia at rest, pale gums and nail beds.

  1. What are the major RBC abnormalities on the smear?

  2. A diagnosis of the "process" is readily made by inspection of the smear, what additional test(s) establish etiology?

  3. What would you expect the red cell indices to show in this case?

  4. If you just had the CBC and red blood cell indices, what other types of anemia would you consider?

  5. How do the morphologic and biochemical abnormalities produce symptoms, signs and complications in this disease?



Case 3:  WBC abnormalities

Blood smear: [WebScope] [ImageScope]

History: 20 year old man was admitted with a three day history of fever, sore throat, dyspnea, and malaise. Febrile, generalized lymphadenopathy, non-exudative pharyngitis, mild hepatomegaly and splenomegaly of 2 cm below the costal margin. He had mild left and right abdominal tenderness without guarding. Normal CBC except for an elevated percentage of lymphocytes (see virtual slide).

  1. What are the major WBC abnormalities on the smear?

  2. What additional test(s) are needed to establish a diagnosis?

  3. What other conditions should you consider?

  4. How are the morphologic abnormalities in the blood smear related to the symptoms, signs, and complications in this disease?



Case 4:  WBC abnormalities

Blood smear: [WebScope] [ImageScope]

History:  After a several day prodrome of fever, chills, cough, and shortness of breath, an elderly patient presented to the emergency department (ED). In the ED, the subject was febrile, hypotensive and hypoxemic. The white count was elevated.

  1. What are the major WBC abnormalities on the smear?

  2. What additional test(s) are needed to establish a diagnosis?

  3. What other conditions should you consider?

  4. How are the morphologic abnormalities in the blood smear related to the symptoms, signs, and complications in this disease?

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