Introduction and Self-Study
- The laboratories focus on the microscopic, genetic and immunologic
features of blood cells essential for the diagnosis of hematologic disorders.
- The first week is a Self-Study exercise that (1) reviews the organization
of hematopoietic organs, (2) introduces the terminology used to describe
blood cells and (3) demonstrates the microscopic features of normal and
abnormal blood smears.
- The second week consists of two in-class laboratories that illustrate
the laboratory diagnosis of anemias, physiologic white blood cell responses
to infections and hematologic neoplasms.
- The laboratories are staffed by three members of the Hematopathology
faculty selected for their commitment to teaching excellence. Each laboratory
uses case-based, interactive exercises that integrate symptoms and signs
with microscopic findings and other laboratory data essential for an
- Diagnostic quality virtual slides are used during the in-class labs.
Please bring your laptops and an ethernet cable so that you can attach
directly to the intranet (provides the best performance for virtual slide
- 10 questions on the final examination are based on the static images,
virtual slides and factual material covered in the laboratories. Only
the images and virtual slides contained in the Hematopathology laboratories
are used for the exam. The Self-study Atlas has a test preparation mode
and a review tool is provided for the virtual slide content as well (Virtual
Slides Self-Tester, link from Laboratory Website)
Self-Study Laboratory (1-07-2013 thru 1-11-2013):
General and detailed objectives for the “Self-Study” lab:
- General: Review normal blood cell development (hematopoiesis).
Learn the microscopic appearance and frequency distribution of normal
erythrocytes, leukocytes and selected anemias. Preview the microscopic
appearance of red and white blood cell disorders discussed during
- Know where normal blood cell growth, differentiation and maturation
occur (e.g. bone marrow, primary or secondary lymphoid organs). Know
the meanings of the terms stem cell, progenitor, precursor, mature
and effector cells. Know where these types of hematopoietic cells are
normally found: Slide 4, Atlas of Normal and Abnormal Hematology (download
- Understand how a blood smear is prepared and evaluated: Slide 5 of
Atlas and Peripheral smear preparation and evaluation document (download
- Know the regions of a blood smear and how to find the optimal areas
for microscopic evaluation: Slides 5-10 of Atlas.
- Know the stage(s) of red and white blood cell maturation that are
normally present in the blood: Slides 4 of Atlas.
- Know the common terms used to describe RBC shapes and sizes: Slide 6
and Slide 18 of Atlas.
- By Monday of week two, be able to identify platelets, mature and
immature erythrocytes in the blood smear. Also have a basic familiarity
with erythrocyte abnormalities: Slides 18-41 of Atlas.
- By Monday of week two, be able to identify normal mature, activated
and immature white blood cells in the blood smear: Slides 11-17 of
- By Monday of week two, have a basic familiarity with abnormal leukocytes
that may appear in the blood smear: Slides 42-51 of Atlas.
The documents for self-study are as follows (click on
name to download or download directly from Path Lab Resources on CTools):
- Peripheral smear preparation and evaluation
- Atlas of normal and abnormal Hematology 2013