|Path Labs||CTools||Lab Instructors||ImageScope||Histology Normals||Histology Site||M1 Histopathology|
GI Path Lab 5
Reading Assignments (Robbins: Pathologic Basis of Disease, 8th Ed.)
|882 - 884||Gallstones|
|885||Morphology of cholecystitis|
|888 - 889||Carcinomas of gallbladder and bile ducts|
|893 - 898||Morphology of pancreatitis|
|465 - 471||Cystic fibrosis|
|900 - 903||Carcinoma of the pancreas|
Areas of Concentration
Upon completion of this exercise, you should be able to:
Believe it or not, this is pancreas. Recognizable islets are evident, embedded within adipose tissue or loose scar. The exocrine parenchyma consists only of dilated ducts, the acini long since having disappeared. Many of the smaller ducts contain thick mucin in their lumens. Compare this slide with Slide 104. They both have much of the same features, but they differ in degree. This section clearly demonstrates why this disease is called “cystic fibrosis.”
Lung: Bronchiectasis (Review)
Lung disease is a significant cause of morbidity and mortality in cystic fibrosis. In fact, these days, bronchiectasis is most often secondary to cystic fibrosis.
Pancreas: Acute Pancreatitis with Enzymatic Fat Necrosis (Review)
Carcinoma of the Pancreas
This slide comes from the duodenal wall and the adjacent head of the pancreas. The adenocarcinoma has several different patterns of growth. In some places, well-developed tubules are formed. In other places, there are only cords of undifferentiated cells, and, in still other areas, single neoplastic cells are found within the stroma. Note also the intense fibrosis around the tumor cells, tubules and nests. This fibrosis is referred to as “desmoplasia.” In some sections, residual islands of pancreatic parenchyma are present with a few ducts, islets, and scattered residual normal acini. The carcinoma also invades the muscularis propria of the duodenum and extends into the adjacent adipose tissue.
The answers to the path lab questions will be posted approximately 48-72 hours after the lab sessions. These are abbreviated answers, not a full discussion of the topics. You can find them in the M2 CTools site resources. In the folder for each sequence the will be a folder called 'Path Lab Resources'