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Clinical Trials

An important facet of the Michigan Comprehensive Diabetes Center (MCDC) is its ground-breaking clinical research. Through clinical trials, our doctors and research staff learn more about diabetes and its complications, while investigating new methodologies and treatments. We are proud to be on the front line of diabetes research with funding from the top agencies, such as the American Diabetes Association, the National Institutes of Health, and the Juvenile Diabetes Research Foundation. The goals of our research are to revolutionize patient care, improve quality of life, and — ultimately — to find a cure.

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Many of the MCDC's innovative studies are making an impact today and have transformed the field of diabetes knowledge and treatment. This would not be possible without study participants, who are our partners in the vital research that we perform. If you, or someone you know, would be interested in helping contribute to medical advances in diabetes, please read about our current clinical trials below. You can find out more details about each study by clicking on its number, which will take you to the sign-up page for that study in the University of Michigan's "Engage" Clinical Trials Database.

Our Current Studies

  • This study is seeking: Patients with specified condition (type 2 diabetes)

    • Other eligibility factors:

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    "Heart Nerve Damage in Patients with Metabolic Syndrome"

    IRB #: HUM00005428   
    (click on the IRB# to see the full study description in the Engage Clinical Trials Database)

    Principal Investigator: Dr. Rodica Pop-Busui
    Study Coordinator: Kathleen A. Ryan, 734-936-2920 or kathr@umich.edu

    ELIGIBILITY CRITERIA:

    • Age range: 18–65 years old
    • This study is seeking: Both healthy subjects and patients with specified condition

    Other eligibility factors:

    • Blood pressure greater than or equal to 130/85 mmHg
    • Diagnosis of Metabolic Syndrome
    • HDL cholesterol: Men < 40 mg/dl, Women < 50 mg/dl
    • If female, must be using contraception to prevent pregnancy
    • Must have (IGT) Impaired Glucose Tolerance
    • Must have no pre-existing cardiovascular, neurological, or kidney disease
    • Must not have diabetes
    • Or must have Impaired Fasting Glucose (IFG) greater than or equal to 100mg/dl
    • Triglyerides greater than or equal to 150 mg/dl
    • Waist circumference: Men > 40 inches, Women > 35 inches

    Compensation: $15.00 for each completed visit and compensation for access to the Metabolic Fitness Program

    "Screening Tests to Look for Pre-Diabetes and Diabetes in Children and Adolescents"

    IRB #: HUM00006955
    (click on the IRB# to see the full study description in the Engage Clinical Trials Database)

    Principal Investigator: Dr. Joyce M. Lee, 734-615-3508 or joyclee@umich.edu

    ELIGIBILITY CRITERIA:

    • Age range: 10–17 years old
    • This study is seeking: Healthy subjects

    Other eligibility factors:

    • Not pregnant
    • Overweight or obese or positive family history for type 2 diabetes

    Compensation: $100 in gift cards after completion of two visits

    "Effect of Exercise on How Much Insulin Is Made and How Well the Body Uses Insulin in Older People"

    IRB #: HUM00008153
    (click on the IRB# to see full study description in the Engage Clinical Trials Database)

    Principal Investigator: Dr. Anne M. Chang
    Study Coordinator: Martina Nabozny, 734-763-4457 or mgrenier@umich.edu

    ELIGIBILITY CRITERIA:

    • Age range: 60–80 years old
    • Smoking: Non-smokers only

    Other eligibility factors:

    • Must be overweight, or have a family history of type 2 (or adult onset) diabetes, or have had gestational diabetes
    • DO NOT ALREADY EXERCISE REGULARLY
    • Enrollment in the study is determined by the blood sugar results obtained during the oral glucose (sugar) tolerance test done at the screening visit (no charge)

    Compensation: Up to $600 and reimbursement for parking

    "Epidemiology of Heterogeneity in Type 2 Diabetes"

    IRB#: HUM00008813
    (click on the IRB# to see full study description in the Engage Clinical Trials Database)

    Principal Investigator: Dr. Massimo T. Pietropaolo
    Study Coordinator: Hope Hooks, 734-998-4969 or hhooks@umich.edu

    ELIGIBILITY CRITERIA:

    • Age range: 40–65 years old
    • This study is seeking: Patients with specified condition (type 2 diabetes)

    Other eligibility factors:

    • Be diagnosed with type 2 diabetes
    • Be on insulin therapy or metformin or combined insulin and metformin therapy
    • Cannot be treated with oral TZD agents
    • Have no history of liver disease
    • Must not be pregnant

    Compensation: Compensation for completion of study varies, depending on extent of involvement in the study.

    "Type 1 Diabetes TrialNet Natural History Studies"

    IRB#: HUM00011027
    (click on the IRB# to see full study description in the Engage Clinical Trials Database)

    Principal Investigator: Dr. Massimo T. Pietropaolo
    Study Coordinator: Cathy Martin, 734-936-6465 or martinc@umich.edu

    ELIGIBILITY CRITERIA:

    • Age range: 1–45 years old
    • This study is seeking: Healthy subjects

    Other eligibility factors:

    • Ages 1 to 18 with second-degree relative with type 1 diabetes
    • Ages 1 to 45 with first-degree relative with type 1 diabetes
    • Family history of type 1 diabetes

    Compensation: None (over 10,000 people are being recruited for the study)

    "Type 2 Diabetes Study for Patients with Severe Kidney Disease"

    IRB#: HUM00018108
    (click on the IRB# to see full study description in the Engage Clinical Trials Database)

    Principal Investigator: Dr. Rodica Pop-Busui
    Study Coordinator: Cynthia Plunkett,734-936-8065 or cplunket@umich.edu

    ELIGIBILITY CRITERIA:

    • Age range: 18–85 years old
    • Other health status: Post-Partum
    • This study is seeking: Patients with specified condition (severe kidney disease)
    Other eligibility factors:
    • Hemoglobin A1c between 6.5%-10%
    • Must not be on hemodialysis or home dialysis
    • Must not have liver disease
    • Must not have had a kidney transplant

    Compensation: None available

    "Study of Exenatide (Byetta) on Neuropathy in Type 2 Diabetes"

    IRB#: HUM00018940
    (click on the IRB# to see full study description in the Engage Clinical Trials Database)

    Principal Investigator: Dr. Rodica Pop-Busui
    Study Coordinator: Cathy Martin, 734-936-6465 or martinc@umich.edu

    ELIGIBILITY CRITERIA:

    • Age range: 18–70 years old
    • Medication: Taking medication
    • This study is seeking: Patients with specified condition (type 2 diabetes)

    Other eligibility factors:

    • HbA1c between 7 and 10%
    • Not taking any of the following medications: Insulin, Byetta, Januvia
    • Mild to moderate peripheral neuropathy

    Compensation: $25.00 per visit