6th Annual John C. Floyd Memorial Fellows Lecture in Endocrinology and Internal Medicine
Medical Grand Rounds Lecture
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"Diagnosis and Management of Pancreatic Neuroendocrine Tumors"
Friday, June 29, 2012
Noon–1:00 p.m.
Ford Amphitheater
2nd floor, University Hospital
SPEAKER:
Aaron Vinik, MD, PhD, FCP, MACP
Professor of Medicine/Pathology/Neurobiology
Director of Research and Neuroendocrine Unit
Strelitz Diabetes Center for Endocrine and Metabolic Disorders
Eastern Virginia Medical School
Box lunches and bottled water will be available from 11:45 a.m.-12:10 p.m. (or until gone.) The lunches are provided by the Department of Internal Medicine for Grand Rounds attendees.
Departmental Grand Rounds can be accessed in real time via interactive video over the internet by clicking on the enclosed link at the time of the event: https://connect.umms.med.umich.edu/intmedg
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Dr. Vinik earned his medical degree at the University of Witwatersrand, South Africa and his internships and residency were completed in Johannesburg. He held an endocrinology fellowship at the University of Cape Town and was a Visiting Fellow in the Department of Pediatric Endocrinology at the University of California-San Francisco, in 1971-1972, before returning to South Africa, where he assumed the roles of Associate Professor of Medicine, Senior Specialist Physician, and Senior Lecturer as well as Co-Director of the Endocrine and Diabetes Research Group in the Department of Medicine at University of Cape Town.
A few years later, Dr. Vinik returned to the U.S. as Professor of Internal Medicine and Surgery in what was then known as the Endocrinology and Metabolism Division at the University of Michigan Medical School, where he served as a physician and internist from 1978 to 1990.
Dr. Vinik is a national leader in basic and clinical neuropathy. He, in essence, has defined the heterogeneity of neuropathy, established a need for a modular approach depending on the particular nerve fiber damaged, and pioneered studies on the relationship between neuropathy, autoimmunity, and cell toxicity. Dr. Vinik also pioneered the use of immunotherapy for autoimmune diabetic neuropathy. He has championed the evaluation of autonomic neuropathy as well as the identification of the site of pathology of diabetic peripheral neuropathy, using contact heat potentials (CHEPS). His advances in the understanding of neuropathy have resulted in patient treatment referrals from all parts of the United States and many other countries. Dr. Vinik has been listed amongst the best physicians in USA for the past nine years.
Dr. Vinik received international recognition as a result of his research on islet regeneration and the discovery of a gene that could prove to be a cure for diabetes. The gene, INGAP (islet neogenesis associated protein), is responsible — either alone or in combination with other factors — for stimulating immature cells in the diabetic pancreas to produce insulin. When INGAP protein was administered to diabetic hamsters, it was shown to reverse diabetes in 40 to 50 percent of animals. Animal studies were followed by human, multi-center clinical studies in both type 1 and type 2 diabetes, carried out by some of the most highly recognized investigators in the country; the results showed that even in type 1 diabetes, an increase in C-peptide (a measure of islet function) could be induced after three months of treatment.
In type 2 diabetes, INGAP was able to stimulate an increase in C-peptide and reduce HbA1c levels by close to 1 percent. Phase 2 clinical trials have been planned as multiple-center, randomized, double-blind, placebo-controlled studies to assess the safety and efficacy of a new formulation of INGAP peptide given subcutaneously as injections for 12 weeks in adult patients with type 1 diabetes, who have been treated with insulin for greater than two years and who are otherwise in good general health. The study selected locations for patients are Montreal, Canada and Rochester, MN.
The discovery of INGAP has far-reaching implications: it could free the 2 million people with type I diabetes from daily injections of insulin; it could help the 20 million people with type 2 diabetes whose pancreas ultimately fails; and, it could be used in genetic screening to identify those predisposed for developing diabetes. The discovery is a result of 16 years of perseverance, committed to the belief (thought by many to be heretical) that islets could be made to grow.
Dr. Vinik has been invited to present his work all over the world. Recognized as a pioneer and a scholar, Dr. Vinik has authored eight books (including one devoted to islet regeneration), 116 book chapters, and has published more than 460 papers in peer-reviewed, highly reputable journals. He has also published more than 400 abstracts and he and the fellows he has trained have presented scientific papers at innumerable national and international meetings. He has been invited to give the Banting Lecture at the University of Toronto, the Minkowski Lecture in Kaunas, Lithuania, and the "INGAP Story" in Helsingor, Denmark at the International Pancreatic Islet Symposium. In 2005, he was elected to Mastership of the American College of Physicians. He has been featured at "Meet the Professor" events at the Endocrine Society, the American Diabetes Association, and the American College of Physicians.
Dr. Vinik received the award for the Virginia Outstanding Scientist by the Science Museum of VA, in 2002 and the Southern Medical Association’s Seale Harris Award in 2003. He received the Dean's Award for Outstanding Research in 1993 and the Dean's Award for Outstanding Faculty in 1999. He was awarded Alpha Omega Alpha in 2004 by students of the Eastern Virginia Medical School.
Dr. Vinik is a member of a number of professional societies, including the American Endocrine, Diabetes, Gastroenterology, and the European and International Diabetes associations. Dr. Vinik served as a member of the National Institutes of Health (NIH) General Clinical Research Center Study Section and the NIH Data Management committee. He was also chairman of the American Diabetes Association Task Force on Nutrition, which established the guidelines for nutritional management of diabetes, and chairman of the subcommittee for development of guidelines for neuropathy testing. In addition, he was a member of the committee to develop guidelines for managing lipid disorders in diabetes. He has served previously as chairperson of the American Diabetes Association Grant Review Committee and as director of the National Post-Graduate Education Course.
Dr. Vinik’s scholarly pursuits include reviewing scientific manuscripts for many journals. He is editor of Endocrine Reviews and associate editor of Diabetes Care. He is also an editor of several books, such as Neuroendocrine Tumors from Interscience Institute; editor of the section on Neuroendocrine Tumors in De Groot’s Textbook of Endocrinology; of the section on Neuroendocrine Tumors in the textbook Cancer Medicine, and co-editor of the textbook Controversies in Treating Diabetes.
Dr Vinik is a featured speaker on diabetic neuropathy in the television series, D-Life, which presents education programs on diabetes to the public.He has received research funding for his studies from the National Institutes of Health, the National Cancer Institute, the Kroc Foundation, the American Diabetes Association, HUD, DHHS, NASA, The Diabetes Institutes Foundation, and the pharmaceutical industry.
Dr. Vinik holds three issued patents and six more patents are being studied. He holds the copyright for the Norfolk Quality of Life tool, used as an end-point for clinical trials in neuropathy for assessing lifestyle problems in patients with diabetic neuropathy. He also holds the copyright for the questionnaire for assessing Quality of Life in patients with neuroendocrine tumors.
Dr. John C. Floyd, Jr.
This annual lecture is made possible by the generosity of
Mrs. Esther Floyd and her family in memory of
her husband, Dr. John C. Floyd, Jr.,
late Professor Emeritus of Internal Medicine in the
Division of Endocrinology & Metabolism and
co-founder/former Associate Director of the
Michigan Diabetes Research and Training Center.
Questions:
Marketing & Communications
Division of Metabolism, Endocrinology & Diabetes
diabetes@umich.edu or (734) 763-0177
