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U-M Brehm Investigators

Santiago Schnell

"Being a U-M Brehm Investigator, to me, means doing state-of-the-art research into finding new treatments for diabetes, and ultimately a cure for the disease. I enjoy working with some of the best biomedical scientists in the field here at U-M, both basic and clinical scientists. The stimulating intellectual environment, excellent colleagues and easy access to the most advanced research technologies taken together will greatly facilitate our efforts to understand and ultimately overcome diabetes and other metabolic diseases. . For these reasons, I am truly delighted to be part of the Brehm Center."


Leslie Satin, Ph.D.
Professor of Pharmacology
U-M Brehm Investigator
Satin Lab

Dr. Leslie Satin is new to the University of Michigan — but not to the study of diabetes. Dr. Satin moved his lab to the U-M in summer 2008 after 18 years at the Virginia Commonwealth University School of Medicine. He has been working to understand diabetes and secretory function in pancreatic islets for nearly a quarter of a century.

Dr. Satin earned his Ph.D. at University of California-Los Angeles with Dr. Douglas Junge. He completed postdoctoral fellowships in the Department of Neurobiology and Behavior at the State University of New York-Stony Brook with Dr. Paul R. Adams, in the Department of Physiology and Biophysics at the University of Washington-Seattle with Dr. Daniel L. Cook, and in Endocrinology and Metabolism at the Seattle VA Medical Center (also with Dr. Cook).

Throughout his career, Dr. Satin has been active in the American Diabetes Association (ADA) as a manuscript reviewer, grant  reviewer, member of the Program Committee for the annual Scientific Sessions Meeting, and member of the Professional and Scientific Oversight Committee. He also has served as a reviewer for many National Institutes of Health study sections dealing with diabetes mechanisms and beta cell function.

Dr. Satin's primary research interests are pancreatic islets, insulin secretion, beta cell function and signaling mechanisms, ion channels, and diabetes. The Satin Lab's work has provided new ways to understand how pulsatile insulin secretion is produced at the level of the islet, in vivo, and how pulsatility is regulated by the beta cell. It is well documented that diabetic patients lose these insulin pulses early in the development of the disease, and that this contributes to hyperglycemia.

Dr. Satin is the recipient of the Diabetes Research Center of Seattle New Investigator Award, the Virginia Commonwealth University School of Medicine Research Award (in Pharmacology), and the Virginia Commonwealth University School of Medicine Teaching Award. He has enjoyed teaching courses in endocrine pharmacology, physiology, and cell signaling to graduate, medical, and other professional students.