John J. Voorhees, MD, FRCP

Duncan and Ella Poth Distinguished Professor
Department Chair

Selected Publications

1. Walter JF, Voorhees JJ, Kelsey WH, Duell EA: Psoralen plus black light inhibits epidermal DNA synthesis. Archives of Dermatology 107:861-865, 1973
2. Walter JF, Voorhees JJ: Psoriasis improved by psoralen plus black light. Acta Dermato-Venereologica 53:469-472, 1973
3. Hammarstrom S, Hamberg M, Samuelsson B, Duell EA, Stawiski M, Voorhees JJ: Increased concentrations of nonesterified arachidonic acid, 12L-hydroxy-5,8,10, 14-eicosatetraenoic acid, prostaglandin E2, and prostaglandin F2a in epidermis of psoriasis. Proceedings of the National Academy of Sciences 72:5130-5134, 1975
4. Hammarstrom S, Hamberg M, Duell EA, Stawiski MA, Anderson TF, Voorhees JJ: Glucocorticoid in inflammatory proliferative skin disease reduces arachidonic and hydroxyeicosatetraenoic acids. Science 197:994-996, 1977
5. Ellis CN, Gorsulowsky DC, Hamilton TA, Billings JK, Brown M.D., Headington JT, Cooper KD, Baadsgaard O, Duell EA, Annesley TM, Turcotte JG, Voorhees JJ: Cyclosporine A improves psoriasis in a double-blind study. Journal of the American Medical Association 256: 3110-3116, 1986
6. Weiss JS, Ellis CN, Headington JT, Tincoff T, Hamilton TA, Voorhees JJ: Topical tretinoin improves photoaged skin: A double-blind vehicle-controlled study. Journal of the American Medical Association 259:527-532, 1988
7. Elder JT, Fisher GJ, Lindquist PB, Bennet GL, Derynck R, Pittelkow M, Ellingsworth L, Voorhees JJ: Overexpression of TGF-β in psoriatic epidermis. Science 243:811-814, 1989
8. Woodley DT, Zelickson AS, Briggaman RA, Hamilton TA, Ellis CN, Weiss JS, Voorhees JJ: Treatment of photoaged skin with topical tretinoin increases epidermal-dermal anchoring fibrils. Journal of the American Medical Association 263:3057-3059, 1990
9. Eisen D, Griffiths CEM, Ellis CN, Duell EA, Voorhees JJ: Effect of topical cyclosporine rinse on oral lichen planus: A double-blind analysis. New England Journal of Medicine 323 (5):290-294, 1990
10. Ellis CN, Fradin MS, Messana JM, Brown M.D., Siegel MT, Hartley AH, Rocher LL, Hamilton TA, Wheeler S, Ellis-Madu M, Duell EA, Annesley TM, Cooper KD, Voorhees JJ: Cyclosporine for psoriasis: Results of a multidose, double-blind trial. New England Journal of Medicine 324(5):277-284, 1991
11. Astrom A, Tavakkol A, Pettersson U, Cromie M, Elder JT, Voorhees JJ: Molecular cloning of human CRABP-I and CRABP-II: Retinoic acid induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro. Journal of Biological Chemistry 266(26):17662-17666, 1991
12. Rafal ES, Griffiths CEM, Ditre CM, Finkel LJ, Hamilton TA, Ellis CN, Voorhees JJ: Topical tretinoin (retinoic acid) treatment for liver spots associated with photoaging. New England Journal of Medicine 326(6):368-374, 1992
13. Duell EA, Astrom A, Griffiths CEM, Chambon P, Voorhees JJ: Human skin levels of retinoic acid and cytochrome P-450 derived 4-OH retinoic acid after topical application of retinoic acid in vivo compared to concentrations required to stimulate retinoic acid receptor mediated transcription in vitro. Journal of Clinical Investigation 90:1269-1274, 1992
14. Astrom A, Pettersson U, Voorhees JJ: Structure of the human cellular retinoic acid-binding protein-II gene: Early transcriptional regulation by retinoic acid. Journal of Biological Chemistry 267:25251-25255, 1992
15. Bulengo-Ransby SM, Griffiths CEM, Kimbrough-Green C, Finkel LJ, Hamilton TA, Ellis CN, Voorhees JJ: Topical retinoic acid for post-inflammatory hyperpigmentation in black patients. New England Journal of Medicine 328:1438-1443, 1993
16. Griffiths CEM, Russman AN, Majmudar G, Singer RS, Hamilton TA, Voorhees JJ: Restoration of collagen formation in photodamaged skin by tretinoin (retinoic acid). New England Journal of Medicine 329(8):530-535, 1993
17. Astrom A, Pettersson U, Chambon P, Voorhees JJ: Retinoic acid induction of human cellular retinoic acid-binding protein-II (CRABPII) gene transcription is mediated by retinoic acid receptor-retinoid X receptor (RAR-RXR) heterodimers bound to one far upstream retinoic acid responsive element (RARE) with 5 base-pair spacing. Journal of Biological Chemistry 269(35):22334-22339, 1994
18. Fisher GJ, Talwar HS, Xiao JH, Datta SC, Reddy AP, Gaub MP, Rochette-Egley C, Chambon P, Voorhees JJ: Immunological identification and functional quantitation of retinoic acid and retinoid X receptor proteins in human skin. Journal of Biological Chemistry 269(32):20629-20635, 1994
19. Varani J, Perone P, Griffiths CEM, Inman DR, Fligiel SEG, Voorhees JJ: All-trans retinoic acid (RA) stimulates events in organ-cultured human skin that underlie repair: Adult skin from sun-protected and sun-exposed sites responds in identical manner to RA while neonatal foreskin responds differently. Journal of Clinical Investigation 94:1747-1756, 1994
20. Xiao JH, Durand B, Chambon P, Voorhees JJ: Endogenous retinoic acid receptor-retinoid X receptor heterodimers are the major functional forms regulating retinoid responsive elements in adult human keratinocytes. Journal of Biological Chemistry. 270(7):3001-3011, 1995
21. Fisher GJ, Datta SC, Talwar HS, Wang ZQ, Varani J, Kang S, Voorhees JJ: Molecular basis of sun-induced premature skin ageing and retinoid antagonism. Nature 379:335-339, 1996
22. Feng X, Peng ZH, Di W, Li XY, Chambon P, Rochette-Egly C, Voorhees JJ, Xiao JH: Suprabasal expression of a dominant-negative retinoid X receptor mutant in transgenic mouse epidermis impairs regulation of gene transcription and basal keratinocyte proliferation by retinoic acid receptor-selective retinoids. Genes and Development 11:59-71, 1997
23. Fisher G, Wang ZQ, Datta S, Varani J, Kang S, Voorhees JJ: Pathophysiology of premature skin aging induced by ultraviolet light. New England Journal of Medicine 337:1419-1428, 1997
24. Fisher GJ, Talwar HS, Lin J, Lin P, McPhillips F, Wang ZQ, Li XY, Wan Y, Kang S, Voorhees JJ: Retinoic acid inhibits induction of c-jun protein by ultraviolet radiation that occurs subsequent to activation of MAP kinase pathways in human skin in vivo. Journal of Clinical Investigation 101:1432-1440, 1998
25. Xiao JH, Feng X, Di W, Peng ZH, Li LA, Chambon P, Voorhees JJ: Identification of heparin-binding EGF-like growth factor as a target in intercellular regulation of epidermal basal cell growth by suprabasal retinoic acid receptors. European Molecular Biology Organization Journal (EMBO Journal) 18:1539-1548, 1999
26. Wang ZQ, Boudjelal M, Kang S, Voorhees JJ, Fisher GJ: Ultraviolet irradiation of human skin causes functional vitamin A deficiency, preventable by all-trans retinoic acid pretreatment. Nature Medicine 5:418-422, 1999
27. Fisher GJ, Datta S, Wang ZQ, Li XY, Quan T, Chung JH, Kang S and Voorhees JJ: c-Jun-dependent inhibition of cutaneous procollagen transcription following ultraviolet irradiation is reversed by all-trans-retinoic acid. Journal of Clinical Investigation 106:663-670, 2000
28. Quan T, He T, Voorhees JJ, Fisher GJ: Ultraviolet irradiation blocks cellular responses to transforming growth factor-β by down-regulating its type-II receptor and inducing Smad7. Journal of Biological Chemistry 276: 26349-26356, 2001
29. Voorhees JJ and others: The International Psoriasis Genetics Study: Assessing linkage to 14 candidate susceptibility loci in a cohort of 942 affected sib-pairs. American Journal of Human Genetics 73:430-438, 2003
30. Wang HQ, Quan T, He T, Franke TF, Voorhees JJ, Fisher GJ: EGF receptor-dependent, NF-κB independent activation of PI-3-kinase/Akt pathway inhibits ultraviolet irradiation-induced caspases 3,8, and 9 in human keratinocytes. Journal of Biological Chemistry 278:45737-45745, 2003
31. Varani J, Schuger L, Dame MK, Leonard C, Fligiel S, Kang S, Fisher GJ, Voorhees JJ: Reduced fibroblast interaction with intact collagen as a mechanism for depressed collagen synthesis in photoaged skin. Journal of Investigative Dermatology 122:1471-1479, 2004
32. Orringer JS, Kang S, Hamilton T, Schumacher W, Cho S, Hammerberg C, Fisher G, Karimipour DJ, Johnson TM, Voorhees JJ: Treatment of acne vulgaris with a pulsed dye laser: A split-face randomized clinical trial. Journal of the American Medical Association 291:2834-2839, 2004
33. Quan T, He T, Kang S, Voorhees JJ, Fisher GJ: Solar UV irradiation reduces collagen in photoaged human skin by blocking TGF-β type II receptor/SMAD signaling. American Journal of Pathology 165:741-751, 2004
34. Quan T, He T, Voorhees JJ, Fisher, GJ: Ultraviolet irradiation induces smad7 via induction of transcription factor AP-1 in human skin fibroblasts. Journal of Biological Chemistry 280:8079-8085, 2005
35. Kang S, Cho S, Chung J, Fisher GJ, Voorhees JJ: Inflammation and extracellular matrix degradation mediated by activated transcription factors NFκB and AP-1 in inflammatory acne lesions in vivo. American Journal of Pathology 166:1691-1699, 2005
36. Cho S, Lowe L, Hamilton TA, Fisher GJ, Voorhees JJ, Kang S: Long term treatment of photoaged human skin with topical retinoic acid improves epidermal cell atypia and thickens the collagen band in papillary dermis. Journal of the American Academy of Dermatology, 53:769-74, 2005
37. Orringer JS, Voorhees JJ, Hamilton T, Hammerberg C, Kang S, Johnson TM, Karimipour DJ, Fisher G: Dermal matrix remodeling following non-ablative laser therapy. Journal of American Academy of Dermatology, 53:775-82, 2005
38. Xu Y, Tan LJ, Grachtchouk V, Voorhees JJ, Fisher GF: Receptor-type protein tyrosine phosphatase-kappa regulates epidermal growth factor receptor function. Journal of Biological Chemistry, 280: 42694-42700, 2005
39. Stuart P, Nair RP, Abecasis GR, Nistor I, Hiremagalore R, Chia NV, Qin ZS, Thompson RA, Jenisch S, Weichenthal M, Janiga J, Lim HW, Christophers E, Voorhees JJ, Elder JT: Analysis of RUNX1 binding site and RAPTOR polymorphisms in psoriasis: No evidence for association despite adequate power and evidence for linkage. Journal of Medical Genetics, 43:12-17, 2006
40. Karimipour DJ, Kang S, Johnson TM, Orringer JS, Hamilton T, Hammerberg C, Voorhees JJ, Fisher GJ: Microdermabrasion with and without aluminum oxide crystal abrasion: A comparative molecular analysis of dermal remodeling. Journal of American Academy of Dermatology, 54:405-410, 2006
41. Rittie L, Varani J, Kang S, Voorhees JJ, Fisher GJ: Retinoid-Induced Epidermal Hyperplasia Is Mediated by Epidermal Growth Factor Receptor Activation Via Specific Induction of its Ligands Heparin Binding-EGF and Amphiregulin in Human Skin In Vivo. Journal of Investigative Dermatology, 126:732-739, 2006
42. Nair RP, Stuart PE, Nistor I, Hiremagalore R, Chia NVC, Jenisch S, Weichenthal M, Abecasis GR, Lim HW, Christophers E, Voorhees JJ, Elder JT: Sequence and Haplotype Analysis Supports HLA-C as the Psoriasis Suceptibility 1 Gene. American Journal of Human Genetics, 78:827-851, 2006
43. Varani J, Dame MK, Rittie L, Fligiel SEG, Kang S, Fisher GJ, Voorhees JJ: Decreased Collagen Production In Chronologically Aged Skin: Roles of Age-Dependent Alteration in Fibroblast Function and Defective Mechanical Stimulation. American Journal of Pathology, 168:1861-1868, 2006
44. Quan T, He T, Shao Y, Kang S, Voorhees JJ, Fisher GJ: Elevated Cysteine-Rich 61 Mediates Aberrant Collagen Homeostasis in Chronologically Aged and Photoaged Human Skin. American Journal of Pathology, 169: 482-490, 2006
45. Orringer JS, Hammerberg C, Lowe L, Kang S, Johnson TM, Hamilton T, Voorhees JJ, Fisher G: The Effects of Laser-Mediated Hair Removal on Immunohistochemical Staining Properties of Hair Follicles. Journal of the American Academy of Dermatology, 55: 402-407, 2006
46. Rittie L, Fisher GJ, Voorhees JJ: Retinoid therapy for photoaging. In, Skin Aging, BA Gilchrest and J Krutmann (eds). Springer, New York, 2006, chapter 13, pp. 143-156
47. Xu Y, Voorhees, JJ, Fisher GJ: Epidermal Growth Factor Receptor (EGRF) is a Critical Mediator of Ultraviolet B Irradiation-Induced Signal Transduction in Immortalized Human Keratinocyte HaCaT Cells. American Journal of Pathology, 169:823-830, 2006
48. Xu Y, Shao Y, Voorhees JJ, Fisher GJ: Oxidative Inhibition of Receptor Type Protein Tyrosine Phosphatase Kappa by Ultraviolet Irradiation Activates EGFR in Human Keratinocytes. Journal of Biological Chemistry, 281:27389-27397, 2006
49. Orringer JS, Kang S, Maier L, Johnson TM, Sachs DL, Karimipour DK, Helfrich YR, Hamilton T, Voorhees JJ: A Randomized, Controlled, Split-face Clinical Trial of 1320-nm Nd:YAG Laser Therapy in the Treatment of Acne Vulgaris. Journal of the American Academy of Dermatology, 56:432-438, 2007
50. Wang F, Garza LA, Kang S, Varani J, Orringer JS, Fisher GJ, Voorhees JJ: In Vivo Stimulation of De Novo Collagen Production Caused by Cross-linked Hyaluronic Acid Dermal Filler Injections in Photodamaged Human Skin. Archives of Dermatology, 143: 155-163, 2007
51. Helfrich YR, Yu L, Ofori A, Hamilton TA, Lambert J, King A, Voorhees JJ, Kang S: Effect of smoking on aging of photoprotected skin: Evidence gathered using a new photonumeric scale. Archives of Dermatology, 143: 397-402, 2007