John J. Voorhees, MD FRCP

Duncan and Ella Poth Distinguished Professor
Department Chair

Selected Publications

• Walter JF, Voorhees JJ, Kelsey WH, Duell EA. Psoralen plus black light inhibits epidermal DNA synthesis. Archives of Dermatology. 1973;107:861-865.
• Walter JF, Voorhees JJ. Psoriasis improved by psoralen plus black light. Acta Dermato-Venereologica. 1973;53:469-472.
• Hammarstrom S, Hamberg M, Samuelsson B, Duell EA, Stawiski M, Voorhees JJ. Increased concentrations of nonesterified arachidonic acid, 12L-hydroxy-5,8,10, 14-eicosatetraenoic acid, prostaglandin E2, and prostaglandin F2a in epidermis of psoriasis. Proceedings of the National Academy of Sciences. 1975;72:5130-5134.
• Hammarstrom S, Hamberg M, Duell EA, Stawiski MA, Anderson TF, Voorhees JJ. Glucocorticoid in inflammatory proliferative skin disease reduces arachidonic and hydroxyeicosatetraenoic acids. Science. 1977;197:994-996.
• Ellis CN, Gorsulowsky DC, Hamilton TA, Billings JK, Brown MD, Headington JT, Cooper KD, Baadsgaard O, Duell EA, Annesley TM, Turcotte JG, Voorhees JJ. Cyclosporine A improves psoriasis in a double-blind study. Journal of the American Medical Association. 1986;256:3110-3116.
• Weiss JS, Ellis CN, Headington JT, Tincoff T, Hamilton TA, Voorhees JJ. Topical tretinoin improves photoaged skin: A double-blind vehicle-controlled study. Journal of the American Medical Association. 1988;259:527-532.
• Elder JT, Fisher GJ, Lindquist PB, Bennet GL, Derynck R, Pittelkow M, Ellingsworth L, Voorhees JJ. Overexpression of TGF-β in psoriatic epidermis. Science. 1989;243:811-814.
• Woodley DT, Zelickson AS, Briggaman RA, Hamilton TA, Ellis CN, Weiss JS, Voorhees JJ. Treatment of photoaged skin with topical tretinoin increases epidermal-dermal anchoring fibrils. Journal of the American Medical Association. 1990;263:3057-3059.
• Eisen D, Griffiths CEM, Ellis CN, Duell EA, Voorhees JJ. Effect of topical cyclosporine rinse on oral lichen planus: A double-blind analysis. New England Journal of Medicine. 1990;323(5):290-294.
• Ellis CN, Fradin MS, Messana JM, Brown MD, Siegel MT, Hartley AH, Rocher LL, Hamilton TA, Wheeler S, Ellis-Madu M, Duell EA, Annesley TM, Cooper KD, Voorhees JJ. Cyclosporine for psoriasis: Results of a multidose, double-blind trial. New England Journal of Medicine. 1991;324(5):277-284.
• Astrom A, Tavakkol A, Pettersson U, Cromie M, Elder JT, Voorhees JJ. Molecular cloning of human CRABP-I and CRABP-II: Retinoic acid induced expression of CRABP-II but not CRABP-I in adult human skin in vivo and in skin fibroblasts in vitro. Journal of Biological Chemistry. 1991;266(26):17662-17666.
• Rafal ES, Griffiths CEM, Ditre CM, Finkel LJ, Hamilton TA, Ellis CN, Voorhees JJ. Topical tretinoin (retinoic acid) treatment for liver spots associated with photoaging. New England Journal of Medicine. 1992;326(6):368-374.
• Duell EA, Astrom A, Griffiths CEM, Chambon P, Voorhees JJ. Human skin levels of retinoic acid and cytochrome P-450 derived 4-OH retinoic acid after topical application of retinoic acid in vivo compared to concentrations required to stimulate retinoic acid receptor mediated transcription in vitro. Journal of Clinical Investigation. 1992;90:1269-1274.
• Astrom A, Pettersson U, Voorhees JJ. Structure of the human cellular retinoic acid-binding protein-II gene: Early transcriptional regulation by retinoic acid. Journal of Biological Chemistry. 1992;267:25251-25255.
• Bulengo-Ransby SM, Griffiths CEM, Kimbrough-Green C, Finkel LJ, Hamilton TA, Ellis CN, Voorhees JJ. Topical retinoic acid for post-inflammatory hyperpigmentation in black patients. New England Journal of Medicine. 1993;328:1438-1443.
• Griffiths CEM, Russman AN, Majmudar G, Singer RS, Hamilton TA, Voorhees JJ. Restoration of collagen formation in photodamaged skin by tretinoin (retinoic acid). New England Journal of Medicine. 1993;329(8):530-535.
• Astrom A, Pettersson U, Chambon P, Voorhees JJ. Retinoic acid induction of human cellular retinoic acid-binding protein-II (CRABPII) gene transcription is mediated by retinoic acid receptor-retinoid X receptor (RAR-RXR) heterodimers bound to one far upstream retinoic acid responsive element (RARE) with 5 base-pair spacing. Journal of Biological Chemistry. 1994;269(35):22334-22339.
• Fisher GJ, Talwar HS, Xiao JH, Datta SC, Reddy AP, Gaub MP, Rochette-Egley C, Chambon P, Voorhees JJ. Immunological identification and functional quantitation of retinoic acid and retinoid X receptor proteins in human skin. Journal of Biological Chemistry. 1994;269(32):20629-20635.
• Varani J, Perone P, Griffiths CEM, Inman DR, Fligiel SEG, Voorhees JJ. All-trans retinoic acid (RA) stimulates events in organ-cultured human skin that underlie repair: Adult skin from sun-protected and sun-exposed sites responds in identical manner to RA while neonatal foreskin responds differently. Journal of Clinical Investigation. 1994;94:1747-1756.
• Xiao JH, Durand B, Chambon P, Voorhees JJ. Endogenous retinoic acid receptor-retinoid X receptor heterodimers are the major functional forms regulating retinoid responsive elements in adult human keratinocytes. Journal of Biological Chemistry. 1995;270(7):3001-3011.
• Fisher GJ, Datta SC, Talwar HS, Wang ZQ, Varani J, Kang S, Voorhees JJ. Molecular basis of sun-induced premature skin ageing and retinoid antagonism. Nature. 1996;379:335-339.
• Feng X, Peng ZH, Di W, Li XY, Chambon P, Rochette-Egly C, Voorhees JJ, Xiao JH. Suprabasal expression of a dominant-negative retinoid X receptor mutant in transgenic mouse epidermis impairs regulation of gene transcription and basal keratinocyte proliferation by retinoic acid receptor-selective retinoids. Genes and Development. 1997;11:59-71.
• Fisher G, Wang ZQ, Datta S, Varani J, Kang S, Voorhees JJ. Pathophysiology of premature skin aging induced by ultraviolet light. New England Journal of Medicine. 1997;337:1419-1428.
• Fisher GJ, Talwar HS, Lin J, Lin P, McPhillips F, Wang ZQ, Li XY, Wan Y, Kang S, Voorhees JJ. Retinoic acid inhibits induction of c-jun protein by ultraviolet radiation that occurs subsequent to activation of MAP kinase pathways in human skin in vivo. Journal of Clinical Investigation. 1998;101:1432-1440.
• Xiao JH, Feng X, Di W, Peng ZH, Li LA, Chambon P, Voorhees JJ. Identification of heparin-binding EGF-like growth factor as a target in intercellular regulation of epidermal basal cell growth by suprabasal retinoic acid receptors. European Molecular Biology Organization Journal (EMBO Journal). 1999;18:1539-1548.
• Wang ZQ, Boudjelal M, Kang S, Voorhees JJ, Fisher GJ. Ultraviolet irradiation of human skin causes functional vitamin A deficiency, preventable by all-trans retinoic acid pretreatment. Nature Medicine. 1999;5:418-422.
• Fisher GJ, Datta S, Wang ZQ, Li XY, Quan T, Chung JH, Kang S and Voorhees JJ. c-Jun-dependent inhibition of cutaneous procollagen transcription following ultraviolet irradiation is reversed by all-trans-retinoic acid. Journal of Clinical Investigation. 2000;106:663-670.
• Quan T, He T, Voorhees JJ, Fisher GJ. Ultraviolet irradiation blocks cellular responses to transforming growth factor-β by down-regulating its type-II receptor and inducing Smad7. Journal of Biological Chemistry. 2001;276:26349-26356.
• Voorhees JJ and others: The International Psoriasis Genetics Study: Assessing linkage to 14 candidate susceptibility loci in a cohort of 942 affected sib-pairs. American Journal of Human Genetics. 2003;73:430-438.
• Wang HQ, Quan T, He T, Franke TF, Voorhees JJ, Fisher GJ. EGF receptor-dependent, NF-κB independent activation of PI-3-kinase/Akt pathway inhibits ultraviolet irradiation-induced caspases 3,8, and 9 in human keratinocytes. Journal of Biological Chemistry. 2003;278:45737-45745.
• Varani J, Schuger L, Dame MK, Leonard C, Fligiel S, Kang S, Fisher GJ, Voorhees JJ. Reduced fibroblast interaction with intact collagen as a mechanism for depressed collagen synthesis in photoaged skin. Journal of Investigative Dermatology. 2004;122:1471-1479.
• Orringer JS, Kang S, Hamilton T, Schumacher W, Cho S, Hammerberg C, Fisher G, Karimipour DJ, Johnson TM, Voorhees JJ. Treatment of acne vulgaris with a pulsed dye laser: A split-face randomized clinical trial. Journal of the American Medical Association. 2004;291:2834-2839.
• Quan T, He T, Kang S, Voorhees JJ, Fisher GJ. Solar UV irradiation reduces collagen in photoaged human skin by blocking TGF-β type II receptor/SMAD signaling. American Journal of Pathology. 2004;165:741-751.
• Quan T, He T, Voorhees JJ, Fisher, GJ. Ultraviolet irradiation induces smad7 via induction of transcription factor AP-1 in human skin fibroblasts. Journal of Biological Chemistry. 2005;280:8079-8085.
• Kang S, Cho S, Chung J, Fisher GJ, Voorhees JJ. Inflammation and extracellular matrix degradation mediated by activated transcription factors NFκB and AP-1 in inflammatory acne lesions in vivo. American Journal of Pathology. 2005;166:1691-1699.
• Cho S, Lowe L, Hamilton TA, Fisher GJ, Voorhees JJ, Kang S. Long term treatment of photoaged human skin with topical retinoic acid improves epidermal cell atypia and thickens the collagen band in papillary dermis. Journal of the American Academy of Dermatology. 2005;53:769-74.
• Orringer JS, Voorhees JJ, Hamilton T, Hammerberg C, Kang S, Johnson TM, Karimipour DJ, Fisher G. Dermal matrix remodeling following non-ablative laser therapy. Journal of American Academy of Dermatology. 2005;53:775-82.
• Xu Y, Tan LJ, Grachtchouk V, Voorhees JJ, Fisher GF. Receptor-type protein tyrosine phosphatase-kappa regulates epidermal growth factor receptor function. Journal of Biological Chemistry. 2005;280:42694-42700.
• Stuart P, Nair RP, Abecasis GR, Nistor I, Hiremagalore R, Chia NV, Qin ZS, Thompson RA, Jenisch S, Weichenthal M, Janiga J, Lim HW, Christophers E, Voorhees JJ, Elder JT. Analysis of RUNX1 binding site and RAPTOR polymorphisms in psoriasis: No evidence for association despite adequate power and evidence for linkage. Journal of Medical Genetics. 2006;43:12-17.
• Karimipour DJ, Kang S, Johnson TM, Orringer JS, Hamilton T, Hammerberg C, Voorhees JJ, Fisher GJ. Microdermabrasion with and without aluminum oxide crystal abrasion: A comparative molecular analysis of dermal remodeling. Journal of American Academy of Dermatology. 2006;54:405-410.
• Rittie L, Varani J, Kang S, Voorhees JJ, Fisher GJ. Retinoid-induced epidermal hyperplasia is mediated by epidermal growth factor receptor activation via specific induction of its ligands heparin binding-EGF and amphiregulin in human skin in vivo. Journal of Investigative Dermatology. 2006;126:732-739.
• Nair RP, Stuart PE, Nistor I, Hiremagalore R, Chia NVC, Jenisch S, Weichenthal M, Abecasis GR, Lim HW, Christophers E, Voorhees JJ, Elder JT. Sequence and haplotype analysis supports HLA-C as the psoriasis suceptibility 1 gene. American Journal of Human Genetics. 2006;78:827-851.
• Varani J, Dame MK, Rittie L, Fligiel SEG, Kang S, Fisher GJ, Voorhees JJ. Decreased collagen production in chronologically aged skin: roles of age-dependent alteration in fibroblast function and defective mechanical stimulation. American Journal of Pathology. 2006;168:1861-1868.
• Quan T, He T, Shao Y, Kang S, Voorhees JJ, Fisher GJ. Elevated cysteine-rich 61 mediates aberrant collagen homeostasis in chronologically aged and photoaged human skin. American Journal of Pathology. 2006;169:482-490.
• Orringer JS, Hammerberg C, Lowe L, Kang S, Johnson TM, Hamilton T, Voorhees JJ, Fisher G. The effects of laser-mediated hair removal on immunohistochemical staining properties of hair follicles. Journal of the American Academy of Dermatology. 2006;55:402-407.
• Rittie L, Fisher GJ, Voorhees JJ. Retinoid therapy for photoaging. In, Skin Aging, BA Gilchrest and J Krutmann (eds). Springer, New York: 2006: chapter 13, pp. 143-156.
• Xu Y, Voorhees, JJ, Fisher GJ. Epidermal growth factor receptor (EGRF) is a critical mediator of ultraviolet B irradiation-induced signal transduction in immortalized human keratinocyte HaCaT cells. American Journal of Pathology. 2006;169:823-830.
• Xu Y, Shao Y, Voorhees JJ, Fisher GJ. Oxidative inhibition of receptor type protein tyrosine phosphatase kappa by ultraviolet irradiation activates EGFR in human keratinocytes. Journal of Biological Chemistry. 2006;281:27389-27397.
• Orringer JS, Kang S, Maier L, Johnson TM, Sachs DL, Karimipour DK, Helfrich YR, Hamilton T, Voorhees JJ. A randomized, controlled, split-face clinical trial of 1320-nm Nd:YAG laser therapy in the treatment of acne vulgaris. Journal of the American Academy of Dermatology. 2007;56:432-438.
• Wang F, Garza LA, Kang S, Varani J, Orringer JS, Fisher GJ, Voorhees JJ. In vivo stimulation of de novo collagen production caused by cross-linked hyaluronic acid dermal filler injections in photodamaged human skin. Archives of Dermatology. 2007;143:155-163.
• Helfrich YR, Yu L, Ofori A, Hamilton TA, Lambert J, King A, Voorhees JJ, Kang S. Effect of smoking on aging of photoprotected skin: Evidence gathered using a new photonumeric scale. Archives of Dermatology. 2007;143:397-402.