Yong Li, Ph.D.

Research Investigator, Department of Dermatology

Selected Publications

1. Inoki K, Li Y, Zhu T, Wu J, Guan KL. TSC2 is phosphorylated and inhibited by Akt and suppresses mTOR signalling. Nat. Cell. Biol. 4:648-657, 2002.
2. Li Y, Inoki K, Yeung R, Guan KL. Regulation of TSC2 by 14-3-3 Binding. J. Biol. Chem. 277 44593–44596, 2002.
3. Shumway SD, Li Y, Xiong Y.14-3-3beta binds to and negatively regulates the tuberous sclerosis complex 2 (TSC2) tumor suppressor gene product, tuberin. J. Biol. Chem. 278:2089-2092, 2002.
4. Li Y, Inoki K, Vacratsis P, Guan KL. The p38 and MK2 kinase cascade phosphorylates tuberin, the tuberous sclerosis 2 (TSC2) gene product, and enhances its interaction with 14-3-3. J. Biol. Chem. 278:13663-13671, 2003.
5. Inoki K*, Li Y*, Xu T, Guan KL. (*: co-first author) Rheb GTPase is a direct target of TSC2 GAP activity and regulates mTOR signaling. Genes Dev. 17:1829-1834, 2003.
6. Chen X, Li Y, Wei K, Li L, Liu W, Zhu Y, Qiu Z, He F. The potentiation role of hepatopoietin on AP-1 is dependent on its sulfhydryl oxidase activity. J Biol Chem. 278: 49022-49030, 2003.
7. Li Y, Corradetti MN, Inoki K, Guan KL. TSC2 fills a GAP in mTOR signaling pathway. Trend. Biochem. Sci. 29:32-38, 2004.
8. Li Y, Inoki K, Guan KL. Biochemical characterizations of small GTPase Rheb and TSC2 GTPase activating protein. Mol. Cell. Bio. 24:7965-7975. 2004.
9. Inoki K, Ouyang H, Li Y, Guan KL. Signaling by TOR protein in cell growth control. Microbiol Mol Biol Rev. 69:79-100, 2005.
10. Yu Y, Li S, Xu X, Li Y, Guan K, Arnold E, Ding J. Structural basis for the unique biological function of small GTPase RHEB. J Biol Chem. 280:17093-100, 2005.
11. Li Y, Inoki K, Vikis H, Guan KL, Biochemistry of TSC2 GAP activity and regulation of Rheb, Methods In Enzymology, Vol. 407:46-54, 2006.
12. Chong H, Inoki K, Li Y, Zhu T, Garcia-Gonzalo F, Rosa J and Guan KL, TSC1 stabilizes TSC2 by inhibiting the interaction between TSC2 and the HERC1 ubiquitin ligase. J Biol Chem, 281(13):8313-6, 2006.