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James T. Elder, MD, PhD

Kirk D. Wuepper Professor of Molecular Genetic Dermatology, Department of Dermatology

Selected Publications

  1. Stoll S, Benedict M, Mitra R, Hiniker A, Elder J, Nunez G. EGF receptor signaling inhibits keratinocyte apoptosis: evidence for mediation by Bcl-XL. Oncogene. 1998;16(11):1493-1499.
  2. Nair RP, Stuart P, Henseler T, Jenisch S, Chia NVC, Westphal E, Schork NJ, Kim J, Lim H W, Christophers E, Voorhees JJ, Elder J. Localization of psoriasis susceptibility locus PSORS1 to a 60 kilobase interval telomeric to HLA-C. Am J Hum Genet. 2000;66:1833-1844.
  3. Stoll SW, Kansra S, Peshick S, Fry DW, Leopold WR, Wiesen J, Sibilia M, Zhang T, Werb Z, Derynck R, Wagner EF, Elder JT. Differential utilization and localization of ErbB receptor tyrosine kinases in skin compared to normal and malignant keratinocytes. Neoplasia. 2001;3:339-350.
  4. Elder JT, Nair RP, Henseler T, Jenisch S, Stuart P, Chia N, Christophers E, Voorhees JJ. The genetics of psoriasis 2001: The odyssey continues. Arch Dermatol. 2001;137:1447-1454.
  5. Stoll SW, Kansra S, Elder JT. Metalloproteinases stimulate ErbB-dependent ERK signaling in human skin organ culture. J Biol Chem. 2002;277:26839-26845.
  6. International Psoriasis Genetics Consortium (Allen M, Barker JNWN, Bowcock AM, Burden AD, Chia N, Capon F, Christophers E, Daly MJ, Elder JT, Helms C, Henseler T, Jenisch S, Menter A, Mistry R, Nair RP, Stuart PE, Tillman D, Trembath RC, Veal C, Voorhees JJ). The international psoriasis genetics study: assessing linkage to 14 candidate susceptibility loci in a 942 affected-sib-pair cohort. Am J Hum Genet. 2003;73:430-437.
  7. Kansra S, Stoll SW, Johnson JL, Elder JT. Autocrine ERK activation in normal human keratinocytes:  Evidence for involvement of metalloproteinase-mediated release of amphiregulin in signalling from ErbB1 to ERK.  Mol Biol Cell. 2004;15:4299-4309.
  8. Kansra S, Stoll SW, Johnson JL, Elder JT. Blockade of keratinocyte proliferation, migration, and ErbB-mediated ERK signaling by inhibitors of Src family kinases. Molecular Pharmacology. 2005;67:1145-1157.
  9. Cluster 17 Collaboration (Abecasis G, Allen M, Barker JNWN, Burden D, Capon F, Christophers E, Elder JT, Fischer J, Giardina E, Gudjonsson JE, Hüffmeier U, Jenisch S, Karason A, Kere J, Nair RP, Novelli G, Qin ZS, Samuelsson L, Sanchez F, Saarialho-Kere U, Ståhle M, Stuart P, Tillman D, Traupe H, Trembath R, Valdimarsson H, Veal C, Voorhees JJ, Weichenthal M). Fine mapping of the psoriasis susceptibility gene PSORS1: A reassessment of risk associated with a putative risk haplotype lacking HLA-Cw6. J Invest Dermatol. 2005;124:921-930.
  10. Nair RP, Stuart PE, Nistor I, Hiremagalore R, Chia NVC, Jenisch S, Weichenthal M, Abeçasis GR, Lim HW, Christophers E, Voorhees JJ, Elder JT:  Sequence and haplotype analysis supports HLA-C as the Psoriasis Susceptibility 1 gene.  American Journal of Human Genetics. 2006;78:827-851.


 

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