Gary J. Fisher, Ph.D.

Harry Helfman Professor of Molecular Dermatology, Department of Dermatology

Selected Publications

1. Xu Y, Shao Y, Voorhees JJ, Fisher GJ: Oxidative inhibition of receptor-type protein-tyrosine phosphatase kappa by ultraviolet irraditiation activates epidermal growth factor receptor in human keratinocytes. J Biological Chemistry 281(37):27389-97, 2006 Sep 15.
2. Quan T, He T, Voorhees JJ, Fisher GJ: Ultraviolet irradiation induces Smad7 via induction of transcription factor AP-1 in skin fibroblasts. J Biol Chem 280:8079-8085, 2005.
3. Orringer JS, Kang S, Johnson, Karimipour DJ, Hamilton T, Hammerberg C, Voorhees JJ, Fisher GJ: Tretinoin treatment prior to CO2 laser resurfacing: a clinical and biochemical analysis. 51:940-946, JAAD, 2004.
4. Fisher GJ, Datta S, Wang ZQ, Li XY, Quan T, Chung, JH, Kang S, Voorhees JJ: c-Jun dependent inhibition of cutaneous procollagen transcription following ultraviolet irradiation is reversed by all-trans retinoid acid. J Clin Invest 106(5):663-670, 2000.
5. Wang ZQ, Boudjelal M, Kang S, Voorhees JJ, Fisher GJ: Ultraviolet irradiation of human skin causes functional vitamin A deficiency, preventable by all-trans retinoic acid pre-treatment. Nature Medicine 5(4):418-422, 1999.
6. Fisher GJ and Voorhees JJ: Molecular mechanisms of photoaging and its prevention by retinoic acid: Ultraviolet irradiation induces MAP kinase signal transduction cascades that induce AP-1-regulated matrix metalloproteinases that degrade human skin in vivo. J Invest Dermatol 3(1):61-68, 1998.
7. Fisher GJ, Wang ZQ, Datta SC, Varani J, Kang S, Voorhees JJ: Pathophysiology of premature skin aging induced by ultraviolet light. New Eng J Med 337(20):1419-1428, 1997.
8. Fisher GJ, Datta SC, Talwar HS, Wang ZQ, Varani J, Kang S, Voorhees JJ: Molecular basis of sun-induced premature skin ageing and retinoid antagonism. Nature 379(6563):335-339, 1996.