Gary J. Fisher, PhD

Harry Helfman Professor of Molecular Dermatology, Department of Dermatology

Selected Publications

1. Fisher GJ, Datta SC, Talwar HS, Wang ZQ, Varani J, Kang S, Voorhees JJ. Molecular basis of sun-induced premature skin ageing and retinoid antagonism. Nature. 1996;379(6563):335-339.
2. Fisher GJ, Wang ZQ, Datta SC, Varani J, Kang S, Voorhees JJ. Pathophysiology of premature skin aging induced by ultraviolet light. New Eng J Med. 1997;337(20):1419-1428.
3. Fisher GJ and Voorhees JJ. Molecular mechanisms of photoaging and its prevention by retinoic acid: Ultraviolet irradiation induces MAP kinase signal transduction cascades that induce AP-1-regulated matrix metalloproteinases that degrade human skin in vivo. J Invest Dermatol. 1998;3(1):61-68.
4. Wang ZQ, Boudjelal M, Kang S, Voorhees JJ, Fisher GJ. Ultraviolet irradiation of human skin causes functional vitamin A deficiency, preventable by all-trans retinoic acid pre-treatment. Nature Medicine. 1999;5(4):418-422.
5. Fisher GJ, Datta S, Wang ZQ, Li XY, Quan T, Chung, JH, Kang S, Voorhees JJ. c-Jun dependent inhibition of cutaneous procollagen transcription following ultraviolet irradiation is reversed by all-trans retinoid acid. J Clin Invest. 2000;106(5):663-670.
6. Orringer JS, Kang S, Johnson, Karimipour DJ, Hamilton T, Hammerberg C, Voorhees JJ, Fisher GJ. Tretinoin treatment prior to CO2 laser resurfacing: a clinical and biochemical analysis. JAAD. 2004;51:940-946.
7. Quan T, He T, Voorhees JJ, Fisher GJ. Ultraviolet irradiation induces Smad7 via induction of transcription factor AP-1 in skin fibroblasts. J Biol Chem. 2005;280:8079-8085.
8. Xu Y, Shao Y, Voorhees JJ, Fisher GJ. Oxidative inhibition of receptor-type protein-tyrosine phosphatase kappa by ultraviolet irraditiation activates epidermal growth factor receptor in human keratinocytes. J Biological Chemistry. September 15, 2006;281(37):27389-27397.