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Andrzej A. Dlugosz, MD

Poth Professor of Cutaneous Oncology
Professor, Department of Dermatology
Professor, Department of Cell and Developmental Biology

Selected Publications

  1. Grachtchouk M, Mo R, Yu S, Zhang X, Sasaki H, Hui CC, Dlugosz AA. Basal cell carcinomas in mice overexpressing Gli2 in skin. Nat Genet. 2000 Mar; 24(3):216-7.
  2. Grachtchouk V, Grachtchouk M, Lowe L, Johnson T, Wei L, Wang A, de Sauvage F, Dlugosz AA. The magnitude of hedgehog signaling activity defines skin tumor phenotype. EMBO J. 2003 Jun 2; 22(11):2741-51. PMCID: PMC156767.
  3. Allen M, Grachtchouk M, Sheng H, Grachtchouk V, Wang A, Wei L, Liu J, Ramirez A, Metzger D, Chambon P, Jorcano J, Dlugosz AA. Hedgehog signaling regulates sebaceous gland development. Am J Pathol. 2003 Dec; 163(6):2173-8. PMCID: PMC1892397.
  4. Hutchin ME, Kariapper MS, Grachtchouk M, Wang A, Wei L, Cummings D, Liu J, Michael LE, Glick A, Dlugosz AA. Sustained Hedgehog signaling is required for basal cell carcinoma proliferation and survival: conditional skin tumorigenesis recapitulates the hair growth cycle. Genes Dev. 2005 Jan 15; 19(2):214-23. Epub 2004 Dec 29. PMCID: PMC545881.
  5. Grachtchouk M, Liu J, Wang A, Wei L, Bichakjian CK, Garlick J, Paulino AF, Giordano T, Dlugosz AA. Odontogenic keratocysts arise from quiescent epithelial rests and are associated with deregulated hedgehog signaling in mice and humans. Am J Pathol. 2006 Sep; 169(3):806-14. PMCID: PMC1698812.
  6. Pasca di Magliano M, Sekine S, Ermilov A, Ferris J, Dlugosz AA, Hebrok M. Hedgehog/Ras interactions regulate early stages of pancreatic cancer. Genes Dev. 2006 Nov 15;20(22):3161-73. PMC1635150.
  7. Michael LE, Westerman BA, Ermilov AN, Wang A, Ferris J, Liu J, Blom M, Ellison DW, van Lohuizen M, Dlugosz AA. Bmi1 is required for Hedgehog pathway-driven medulloblastoma expansion. Neoplasia. 2008 Dec; 10(12):1343-9, 5p following 1349. PMCID: PMC2586685.
  8. Yang SH, Andl T, Grachtchouk V, Wang A, Liu J, Syu LJ, Ferris J, Wang TS, Glick AB, Millar SE, Dlugosz AA. Pathological responses to oncogenic Hedgehog signaling in skin are dependent on canonical Wnt/beta-catenin signaling. Nat Genet. 2008 Sep; 40(9):1130-5. doi: 10.1038/ng.192. PMCID: PMC2688690.
  9. Dlugosz AA, Talpaz M. Following the hedgehog to new cancer therapies. N Engl J Med. 2009 Sep 17;361(12):1202-5. Epub 2009 Sep 2.
  10. Ames HM, Bichakjian CK, Liu GY, Oravecz-Wilson KI, Fullen DR, Verhaegen ME, Johnson TM, Dlugosz AA, Ross TS. Huntingtin-interacting protein 1: a Merkel cell carcinoma marker that interacts with c-Kit. J Invest Dermatol. 2011 Oct; 131(10):2113-20. doi: 10.1038/jid.2011.171. Epub 2011 Jun 23. PMCID: PMC3174286.
  11. Grachtchouk M, Pero J, Yang SH, Ermilov AN, Michael LE, Wang A, Wilbert D, Patel RM, Ferris J, Diener J, Allen M, Lim S, Syu LJ, Verhaegen M, Dlugosz AA. Basal cell carcinomas in mice arise from hair follicle stem cells and multiple epithelial progenitor populations. J Clin Invest. 2011 May; 121(5):1768-81. doi: 10.1172/JCI46307. Epub 2011 Apr 25. PMCID: PMC3083781.
  12. Syu LJ, El-Zaatari M, Eaton KA, Liu Z, Tetarbe M, Keeley TM, Pero J, Ferris J, Wilbert D, Kaatz A, Zheng X, Qiao X, Grachtchouk M, Gumucio DL, Merchant JL, Samuelson LC, Dlugosz AA. Transgenic expression of interferon-? in mouse stomach leads to inflammation, metaplasia, and dysplasia. Am J Pathol. 2012 Dec;181(6):2114-25. Epub 2012 Oct 1. PMCID: PMC3509761.


 

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