Andrzej A. Dlugosz, MD

Poth Professor of Cutaneous Oncology
Professor, Department of Dermatology
Professor, Department of Cell and Developmental Biology

Selected Publications

1. Chiang C, Swan RZ, Grachtchouk M, Bolinger M, Litingtung Y, Robertson E, Cooper MK, Gaffield W, Westphal H, Beachy PA, and Dlugosz AA. Essential role for Sonic hedgehog during hair follicle morphogenesis. Dev Biol. 1999;205:1-9.
2. Ding Q, Fukami S-i, Meng X, Nishizaki Y, Zhang H, Sasaki H, Dlugosz A, Nakafuku M and Hui C-c. Mouse suppressor of fused is a negative regulator of Sonic hedgehog signaling and alters the subcellular distribution of Gli1. Curr Biol. 1999;9:1119-1122.
3. Grachtchouk M, Rong M, Sandy Y, Zhang X, Sasaki H, Hui C-c and Dlugosz AA. Basal cell carcinomas in mice overexpressing Gli2 in skin. Nature Genet. 2000;24:216-217.
4. Sheng H, Goich S, Wang A, Grachtchouk M, Lowe L, Mo R, Lin K, de Sauvage FJ, Sasaki H, Hui C-c, and Dlugosz AA. Dissecting the oncogenic potential of Gli2 in skin: deletion of an NH2-terminal fragment alters tumor phenotype. Cancer Res. 2002;62:5308-5316.
5. Mill P, Mo R, Fu H, Grachtchouk M, Kim PCW, Dlugosz AA, and Hui CC. Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development. Genes & Dev. 2003;17:282-94.
6. Van Mater D, Kolligs FT, Dlugosz A, and Fearon ER. Transient activation of β-catenin signaling in cutaneous keratinocytes is sufficient to trigger the active growth phase of the hair cycle in mice. Genes & Dev. 2003;17:1219-1224.
7. Grachtchouk V, Grachtchouk M, Lowe L, Johnson TJ, Wei L, Wang A, de Sauvage F, and Dlugosz AA. The magnitude of hedgehog signaling activity defines skin tumor phenotype. EMBO J. 2003;22:2741-2751.
8. Allen M, Grachtchouk M, Sheng H, Grachtchouk V, Wang A, Wei L, Liu J, Ramirez A, Metzger D, Chambon P, Jorcano J, Dlugosz, AA. Hedgehog signaling regulates sebaceous gland development. Am J Pathol. 2003;163:2173-2178.
9. Cui C, Elsam T, Tian Q, Seykora JT, Grachtchouk M, Dlugosz A, and Tseng H. Gli proteins up-regulate the expression of basonuclin in basal cell carcinoma. Cancer Res. 2004;64:5651-5658.
10. Brancaccio A, Minichiello A, Grachtchouk M, Antonini D, Sheng H, Parlato R, Dathan N, Dlugosz AA, Missero C. Requirement of the forkhead gene Foxe1, a target of sonic hedgehog signaling, in hair follicle morphogenesis. Hum Mol Genet. 2004;13:2595-2606.
11. Hutchin ME, Kariapper MST, Grachtchouk M, Wang A, Wei, L, Cummings D, Liu J, Michael LE, Glick A, Dlugosz AA. Sustained Hedgehog signaling is required for basal cell carcinoma proliferation and survival: conditional skin tumorigenesis recapitulates the hair growth cycle. Genes & Dev. 2005;19:214-223.
12. Roessler E, Ermilov AN, Grange DK, Wang A, Grachtchouk M, Dlugosz AA, Muenke M. A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2. Hum Mol Genet. 2005;14:2181-2188.