Residents and Research

We are committed to the development of our residents and recognize the valuable contributions that they bring to our research efforts. U-M Dermatology faculty members work closely with each resident, providing guidance and support for their clinical or laboratory research activities. The outcome of this teamwork is an impressive body of publications and presentations by our residents.

• Recent Publications by U-M Dermatology Residents
• Recent Presentations by U-M Dermatology Residents

Recent Research Publications by U-M Dermatology Residents

• Sigmundsdottir H., Gudjonsson JE, Jonsdottir I, Ludviksson BR, Valdimarsson H. The frequency of CLA+ CD8+ T cells in the blood of psoriasis patients correlate closely with the severity of their disease. Clin. Exp. Immunolog. 2001: 126:365-369.
• Paek SC, Merritt DF, Mallory SB. Pruritus vulvae in prepubertal children. J Am Acad Dermatol 44(5):795-802; 2001.
• Ellis CN, Krach KJ. Uses and complications of isotretinoin therapy. J Am Acad Dermatol 2001; 45:S150-157.
• Hanakawa Y, Lin C, Garza L, Sugai M, Schechter N, Amagai M, Stanley J: Molecular Mechanisms for Specific Cleavage of Desmoglein 1 by Exfoliative Toxins. Journal of Clinical Investigation. 110(1):53-60, 2002
• Liao PB, Rubinson R, Howard R, Sanchez G, Frieden IJ. Annular pustular psoriasis--most common form of pustular psoriasis in children: report of three cases and review of the literature. Pediatr Dermatol. 2002 Jan-Feb; 19(1): 19-25.
• Gudjonsson JE, Karason A, Antonsdottir AA, Runarsdottir EH, Gulcher JR, Stefansson K, Valdimarsson H. HLA-Cw6-Positive and HLA-Cw6-Negative Patients with Psoriasis Vulgaris have Distinct Clinical Features. J. Invest. Dermatol 2002 Feb;118:362-365.
• Ellis CN, Brown MF, Voorhees JJ: Sulfasalazine for alopecia areata. J Am Acad Dermatol 2002; 46:541-4.
• Gillard MO, Wang TW, Boyd CM, Dunn RL, Fader DJ, Johnson TM. Conventional diamond fraise vs manual spot dermabrasion with drywall sanding screen for scars from skin cancer surgery. Arch Dermatol 138:1035-1039, 2002.
• Karason A, Gudjonsson JE, Upmanyu R, Antonsdottir AA, Hauksson VB, Runarsdottir EH, Jonsson H, Stefansson K, Valdimarsson H, Gulcher J. A susceptibility gene for psoriatic arthritis maps to chromosome 16q: evidence for imprinting. American Journal of Human Genetics 2003 Jan; 72: 125-132.
• Gudjonsson JE, Karason A, Antonsdottir AA, Runarsdottir EH, Gulcher JR, Stefansson K, Valdimarsson H. Psoriasis patients who are homozygous for the HLA-Cw602 allele have a three-fold increased risk of getting psoriasis than Cw6 heterozygotes. British Journal of Dermatology. 2003 Feb;148:233-5.
• Fullen DR, Jacobson SN, Valdez R, Fovice FM, Lowe L. Granuloma annulare-like infiltrates with concomitant cutaneous involvement by B-cell non-Hodgkin's lymphoma: report of a case. Am J Dermatopathol 01 Feb 2003; 25(1): 57-61.
• Sidbury R, Neuschler N, Neuschler E, Sun P, Wang XQ, Miller R, Tomai M, Puscasiu E, Gugneja S, Paller AS. Topically Applied Imiquimod Inhibits Vascular Tumor Growth In Vitro. J Invest Dermatol 121:1205-1209, 2003.
• Altman JF, Lowe L, Redman B, Esper P, Schwartz JL, Johnson TM, Haefner HK: Placental metastasis of maternal melanoma. J Am Acad Dermatol 49: 1150-1154, 2003.
• Altman J, Johnson TM, Redman B, Esper P, Schwartz JL, Lowe L, Haefner HK: Placental metastasis of maternal melanoma. J Am Acad Dermatol. 2003;49:1150-4.
• Bezanis G, Wang TS, Johnson TM, Lowe L: Verrucous plaques on the leg. Arch Dermatol. 2003, Jul;139:933-8.
• Nguyen DB, Patterson JW, Wilson BB. Syringoma of the moustache area. Journal of the American Academy of Dermatology, August 2003.
• Samson Yashar S, Gielczyk R, Scherschun L, Lim HW. Narrow-band ultraviolet B treatment for vitiligo, pruritus, and inflammatory dermatoses. Photodermatology, Photoimmunology and Photomedicine. 19(4):164-8, 2003 Aug.
• Gudjonsson JE, Thorarinsson AM, Kristinsson KG, Valdimarsson H. Streptococcal throat infections and exacerbation of chronic plaque psoriasis - a prospective study.The British Journal of Dermatology 2003 Sept;149:530-4.
• Bhavnani SK, Bichakjian CK, Johnson TM, Little RJ, Peck Z F, Schwartz JL, Strecher VJ. Strategy Hubs: Next-generation domain portals with search procedures. Proceedings of CHI'03. 2003; 393-400.
• Garza LA. Atopic Dermatits: A Review. Postgraduate Dermatology. 1(2):1-3, 2003
• Sexton KE, Lee HT, Massa M, Padia J, Patt WC, Liao P, Pontrello JK, Roth BD, Spahr MA, Ramharack R. Inhibitors of lipoprotein(a) assembly. Bioorganic and Med Chem. 2003 Nov 3; 11(22): 4827-4845.
• Sigmundsdottir H, Gudjonsson JE, Valdimarsson. H Interleukin-12 alone can not enhance the expression of the cutaneous lymphocyte associated antigen (CLA) by superantigen stimulated T lymphocytes. Clin. Exp Immunolog. 2003.
• Valdimarsson H, Vikingsdottir T, Bang P, Saevarsdottir S, Gudjonsson JE, Oskarsson O, Christiansen M, Blou L, Laursen I, Koch C. Human plasma-derived mannose-binding lectin: a phase I safety and pharmacokinetic study. Scand J Immunol 2004 Jan; 59:97-102.
• Gudjonsson JE, Johnston A, Sigmundsdottir H, Valdimarsson H. Immunopathogenic mechanisms in psoriasis. Clin. Exp Immunol 2004 Jan; 135:1-8
• Sigmundsdottir H, Johnston A, Gudjonsson JE, Valdimarsson H. Differential effects of interleukin 12 and interleukin 10 on superantigen-induced expression of cutaneous lymphocyte-associated antigen (CLA) and alphaEbeta7 integrin (CD103) by CD8+ T cells. Clin Immunol 2004 Apr; 111:119-25.
• Deramo, SA. Eruptions of Pregnancy: A Review of Four Dermatoses. Postgraduate Dermatology. 1:1-2, 2004
• Garza LA, Yoo EK, Junkins-Hopkins J, VanVoorhees. Photo Recall-Like Effect with Cefazolin: A Case Report. Cutis. 73(1):79-80,85, 2004
• Garza LA. Seborrheic Dermatitis: A Review. Postgraduate Dermatology. 2 (1):1-2, 2004
• Sigmundsdottir H, Johnston A, Gudjonsson JE, Bjarnason B, Valdimarsson H. Methotrexate markedly reduces the expression of vascular E-selectin, cutaneous lymphocyte associated antigen and the numbers of mononuclear leucocytes in psoriatic skin. Exp Dermatol 2004 Jul; 13:426-34.
• Nguyen DB, Turner JT, Olsen C, Biesecker LG, Darling TN. Cutaneous manifestations of Proteus syndrome: correlations with general clinical severity. Archives of Dermatology, August 2004.
• Valdimarsson H, Karason A, Gudjonsson JE. Psoriasis: a complex clinical and genetic disorder. Curr Rheumatol Rep 2004 Aug; 6:314-6.
• Johnston A, Gudjonsson JE, Sigmundsdottir H, Love T, Valdimarsson H. Peripheral blood T cell responses to keratin peptides that share sequences with M proteins are largely restricted to skin-homing CD8+ T cells. Clin. Exp Immunol 2004 Oct;138:83-93.
• Avram AM, Gielczyk R, Su L, Vine AK, Sisson JC. Choroidal and skin metastases from papillary thyroid cancer: case and a review of the literature. Journal of Clinical Endocrinology and Metabolism. 89 (11): 5303-5307, 2004 Nov.
• Stasko T, Brown MF, et al. Guidelines for the management of squamous cell carcinoma in organ transplant recipients. Dermatol Surg. 2004;30:642-50.
• Johnston A, Gudjonsson JE, Ludviksson BR, Valdimarsson H. The Anti-Inflammatory Action of Methotrexate is not Mediated by Lymphocyte Apoptosis, but by the Suppression of Activation and Adhesion Molecules. Clin Immunol 2005 Feb;114:154-63.
• YL Rosi, L Lowe, S Kang. Treatment of hidradenitis suppurativa with infliximab in a patient with Crohn's disease. J Dermatolog Treat. 2005;16: 58-62.
• Hutchin ME, Kariapper M, Grachtchouk M, Wang A, Wei L, Cummings D, Liu J, Michael LE, Glick AB, and Dlugosz AA. Sustained Hedgehog signaling is required for basal cell carcinoma proliferation and survival: conditional skin tumorigenesis recapitulates the hair growth cycle. Genes Dev. 2005 19: 214-223.

In Press

• Gudjonsson JE. Fine Mapping of the Psoriasis Susceptibility Gene PSORS1: A Reassessment of Risk Associated With a Putative Risk Haplotype Lacking HLA-Cw6. The Cluster 17 Collaboration. J Invest Dermatol (in press)
• Karason A, Gudjonsson JE, Jonsson HH, Hauksson VB, Runarsdottir EH, Stefansson K, Valdimarsson H, Gulcher JR. Genetics of Psoriasis in Iceland: Evidence for Linkage of Subphenotypes to Distinct Loci. J Invest Dermatol (in press)
• Sigmundsdóttir H, Gudjonsson JE, Valdimarsson H. The effects of UVB treatment on the expression of adhesion molecules by circulating T lymphocytes in psoriasis. British Journal of Dermatology (Accepted-in press).

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Recent Research Presentations by U-M Dermatology Residents

• Gudjonsson JE. Methotrexate inhibits the expression of ICAM and CLA by T cells in vitro through different pathways. JE Gudjonsson, H Sigmundsdottir, BR Ludviksson, H Valdimarsson. International Psoriasis Symposium and European Congress on Psoriasis, San Francisco. June 19-24, 2001
• Gudjonsson JE. HLA-Cw6 positive and negative patients with psoriasis vulgaris have distinctly different clinical features. JE Gudjonsson, A Kárason, A Antonsdóttir, H Runarsdottir, J Gulcher, K Stefansson, H Valdimarsson. International Psoriasis Symposium and European Congress on Psoriasis, San Francisco. June 19-24, 2001
• Gudjonsson JE. HLA-Cw6 positive and negative patients with psoriasis vulgaris have distinctly different clinical features. JE Gudjonsson, A Kárason, A Antonsdóttir, H Runarsdottir, J Gulcher, K Stefansson, H Valdimarsson. 11th International Congress of Immunology. Stockholm, July 2001.
• Gudjonsson JE. Clinical features of psoriasis in context of genetic mapping. JE Gudjonsson, A Karason, A Antonsdottir, H Rúnarsdóttir, VB Hauksson, R Upmanyu, I Nachmias, J Gulcher, K Stefansson, H Valdimarsson. NPF psoriasis genetic meeting, Nice France, April 2002.
• Gudjonsson JE. Streptococcal throat infections cause exacerbation of chronic plaque psoriasis - a prospective study. JE Gudjonsson, AM Thorarinsson, B Sigurgeirsson, KG Kristinsson, H Valdimarsson. London, November 2002. Psoriasis: From gene to clinic.
• Paek SC. Odontogenic Sinus Presenting as a Persistent Pustule on the Chin. American Academy of Dermatology, March 2003.
• Hutchin ME, Kariapper M, Grachtchouk M, Wang A, Wei L, Cummings D, Liu J, Michael LE, Glick AB, and Dlugosz AA. Sustained Hedgehog signaling is required for basal cell carcinoma proliferation and survival: conditional skin tumorigenesis recapitulates the hair growth cycle. Society for Investigative Dermatology, Minisymposia Presentation. April, 2004; Providence, RI.
• Gudjonsson JE. Distinct Clinical Differences between HLA-Cw*0602 Positive and Negative Psoriasis Patients: Potential Pharmacogenomic and Immunopathogenic Variations Might be Useful in Predicting Therapeutic responses to Biologic Agents. BI resident/fellow conference on psoriasis. Dallas May 21st-23rd 2004
• Long W. "Adult Xanthogranuloma" Gross and Microscopic Symposium, American Academy of Dermatology Meeting 2004, Washington, D.C.
• Rosi, Y. "Subcutaneous sarcoidosis during interferon-alpha and ribavirin therapy in a patient with hepatitis C," Gross and Microscopic Symposium, American Academy of Dermatology Meeting, Washington, D.C., 2004
• Maier L, Su L. Atypical Erythema Multiforme in a Patient Receiving Intravenous Immunoglobulin. Abstract accepted for presentation at Gross & Microscopic Dermatology Symposium during the 63rd AAD Annual Meeting (2005).
• Hutchin ME, Liu J, Wang , Grachtchouk M, Wei L, Waldinger J, Glick AB, and Dlugosz AA. Hedgehog signal transduction in hair follicle epithelium is essential for proper epithelial-mesenchymal interactions and post-natal hair morphogenesis. Society for Investigative Dermatology. Poster Session. May, 2005; St. Louis, MO.

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