The purpose of this NIH sponsored training grant is to provide an intensive research training experience in basic or translational cardiovascular research. The program is designed for postdoctoral MD's or PhD's in preparation for independent investigative careers related to cardiovascular disease. Cardiovascular fellowship applicants will find this an especially valuable opportunity to focus on an area of research interest under the guidance of established mentors in the field. A diverse array of training opportunities are available ranging from basic mechanisms of vascular disease to applied translational research. The University of Michigan Cardiovascular Center, Department of Internal Medicine, comprises the central foundation of this grant, although multiple links to other Divisions and Departments within the University of Michigan Medical School have been established to facilitate collaborations and novel pursuits in this rapidly expanding field. In addition to a multitude of basic research opportunities available through this grant, a translational scientific program has been developed to meet the needs of trainees interested in clinical investigation. This translational research program also provides an opportunity to complete a Masters of Science program in research design and statistical analysis within the University of Michigan School of Public Health.

A core curriculum of didactic seminars designed specifically for trainees, interdisciplinary symposia and journal clubs have been established. Funding through this grant is available for 2-3 years.

For questions about this NIH Training Grant Program, contact John Burnett (Internal Medicine, Division of Cardiology, Cardiovascular Training Grant Coordinator) at dual@umich.edu.

The University of Michigan is an equal opportunity employer seeking under-represented minorities to train in our research environment.

Research Opportunities

• Signaling pathways in ischemia-reperfusion injury
• CD39 ectonucleotidase in coagulation and inflammation
• PAI-1 in atherosclerosis and thrombosis
• Leptin in thrombosis and atherosclerosis
• Genetic modifiers of obesity
• Glycophingolipids in vascular disease
• Molecular mechanisms of cardiomyocyte differentiation from embryonic precursors
• Role of troponin I in the adult cardiac myocyte contractile response to PKC
• Molecular mechanisms regulating smooth muscle proliferation
• Role of cardiac renin-angiotension system in myocyte hypertrophy
• Novel genetic modifiers of thrombosis
• Structure and function of voltage-gated sodium channels
• Mechanisms involved in obesity-induced hypertension
• Regulation of protein folding
• Protein-protein interaction domains in cell signaling
• Basic mechanisms of hypertrophic cardiomyopathy
• G-protein mediated pathways in cardiovascular disease
• The kallikrein/kinin system in vascular disease
• Mechanisms involved in pulmonary fibrosis
• Sympathetic nervous system and adrenergic responsiveness in aging
• Inflammation in venous thrombosis
• Genetic modifiers of hypertension
• Matrix metalloproteinases in vascular disease
• Tools for measuring cardiovascular complications of diabetes
• Cardiovascular outcomes
  

Participating investigators

Bernstein, Steven, MD, MPH
Associate Professor of Internal Medicine
Associate Research Scientist of Health Management & Policy

Bodary, Peter
Research Investigator, Department of Internal Medicine

Duan, Cunming, PhD
Associate Professor of Molecular, Cellular,
and Developmental Biology

Day, Sharlene, MD
Assistant Professor, Department of Internal Medicine

Eagle, Kim A., MD, FACC
Albion Walter Hewlett Professor, Internal Medicine
Clinical Director of Cardiovascular Center

Eitzman, Daniel, MD
Associate Professor of Internal Medicine
Division of Cardiovascular Medicine
Director & Principal Investigator of Cardiovascular Research Training Grant

Ginsburg, David, MD
James V. Neel Distinguished University Professor
Professor of Internal Medicine and Human Genetics
Investigator of Howard Hughes Medical Institute

Gordon, David, MD
Associate Dean for Diversity & Career Development
Professor of Pathology

Grekin, Roger J., MD
Professor of Internal Medicine, Division of Endocrinology
VA Associate Chief of Staff, Research & Development

Hayward, Rodney A., MD
Director, VA Center for Practice Mgmt. & Outcome Research
Professor of Internal Medicine & Public Health Mgmt. & Policy
Director, Measurement Core, MI Diabetes Research & Training Center

Isom, Lori L., PhD
Associate Professor of Pharmacology

Jamerson, Kenneth, MD
Professor, Department of Internal Medicine

Kaplan, George
Research Professor, Institute for Social Reserach

Kaufman, Randal J., PhD
Professor of Internal Medicine & Biological Chemistry
Research Investigator, Howard Hughes Medical Institute

Lawrence, Daniel, PhD
Professor, Department of Internal Medicine

Lucchesi, Benedict R., MD, PhD, FAHA
Professor of Pharmacology

Margolis, Benjamin, MD
Professor of Internal Medicine and Biological Chemistry
Associate Investigator of Howard Hughes Medical Institute

Metzger, Joseph, PhD
Professor of Internal Medicine & Physiology
Director, Center for Integrative Genomics
Research Professor of Gerontology

Mortensen, Richard, MD, PhD
Associate Professor of Molecular & Integrative Physiology
Associate Professor of Pharmacology, Metabolism, Endocrinology, & Diabetes

Myers, Martin
Assistant Professor, Department of Internal Medicine

Nallamothu, Brahmajee
Assistant Professor, Department of Internal Medicine

Neubig, Richard, MD, PhD
Professor of Internal Medicine & Pharmacology

Pinsky, David J., MD
J. Griswold Ruth M.D.& Mary Hopkins Ruth Professor of Internal Medicine
Chief of Cardiovascular Medicine
Professor, Molecular & Integrative Physiology
Scientific Director, Cardiovascular Center

Shayman, James A., MD
Professor of Internal Medicine & Pharmacology
Division of Nephrology
Associate Chair, Research Program

Simon, Richard H., MD
Professor of Internal Medicine
Division of Pulmonary and Critical Care Medicine

Upchurch, Gilbert, MD
Associate Professor of Vascular Surgery

Wakefield, Thomas, MD
Professor of Vascular Medicine
Chief, Vascular Surgery Department

Weder, Alan B., MD
Professor of Internal Medicine
Co-Director, Vascular Medicine, Division of Cardiology

Weiss, Stephen J., MD
Chief, Molecular Medicine & Genetics
Upjohn Professor of Oncology

Westfall, Margaret V., PhD
Assistant Professor of Surgery