Anticoagulation Management Service For Health Professionals
Intensity of Warfarin Anticoagulation for Different Thrombotic Disorders
Notes:
1. These indications and recommended intensities of treatment are derived from the Eighth American College of Chest Physicians Consensus Conference (2008).
2. For most indications a therapeutic range of 2.0 to 3.0 is recommended. A higher INR range of 2.5 to 3.5 is recommended for parents with mechanical prosthetic valves and post myocardial infarction and for some patients with antiphospholipid syndrome and a history of thrombosis.
| Intensity of Warfarin Anticoagulation American College of Chest Physicians Guidelines* |
|||
| Indication | INR Range | Target | Suggested Duration |
| Prophylaxis of venous thrombosis (total hip replacement, total knee arthroplasty and hip fracture surgery) | 2.0-3.0 | 2.5 | 1 month |
| Treatment of venous thrombosis Treatment of PE |
2.0-3.0 | 2.5 | 3-6 months |
|
AMI (to prevent systemic embolism)
|
2.0-3.0 2.0 - 2.5 |
2.5
|
3-6 months 3-6 months |
| Atrial fibrillation and/or flutter | 2.0-3.0 | 2.5 | indefinite |
| Certain patients with thrombosis and antiphospholipid antibody syndrome | 3.0 - 4.0 | 3.5 | indefinite |
| Tissue and mechanical heart valves | |||
Revised 6/15/2009
