Bioluminescence

IVIS 200 View

PerkinElmer's IVIS™ 200 imaging system is an advanced single-view 2D and 3D optical imaging system designed to improve quantitative outcomes of in vivo imaging. It uses a patented optical imaging technology to facilitate non-invasive longitudinal monitoring of disease progression, cell trafficking and gene expression patterns in living animals. The system includes a highly sensitive camera, a dark imaging chamber to minimize incident light, and software to quantify the results. The IVIS imaging systems start with a back-thinned CCD camera, designed for high-efficiency photon detection, particularly in the important red region of the spectrum. It can detect very small numbers of photons as well as operate as a traditional camera; displaying images in that wide signal range is a function of the system's Living Image™ software. The CCD is cooled and the electronic readout is optimized so that the data gathered to create the real-time in vivo images have extremely low noise. Up to 5 animals can be imaged at a time and thermoregulation is achieved by means of a heated stage. Inhalable anesthesia is delivered via nose cones throughout the imaging procedure.

IVIS Spectrum View

PerkinElmer's IVIS™ Spectrum imaging system The IVIS® Spectrum in vivo imaging system uses a novel patented optical imaging technology to facilitate non-invasive longitudinal monitoring of disease progression, cell trafficking and gene expression patterns in living animals. The IVIS Spectrum is a versatile and advanced in vivo imaging system. An optimized set of high efficiency filters and spectral un-mixing algorithms lets you take full advantage of bioluminescent and fluorescent reporters across the blue to near infrared wavelength region. The system includes a highly sensitive camera, a dark imaging chamber to minimize incident light, and software to quantify the results. The IVIS imaging systems start with a back-thinned CCD camera, designed for high-efficiency photon detection, particularly in the important red region of the spectrum. It can detect very small numbers of photons as well as operate as a traditional camera; displaying images in that wide signal range is a function of the system's Living Image™ software. The CCD is cooled and the electronic readout is optimized so that the data gathered to create the real-time in vivo images have extremely low noise. Up to 5 animals can be imaged at a time and thermoregulation is achieved by means of a heated stage. Inhalable anesthesia is delivered via nose cones throughout the imaging procedure.

Fluorescence

CRi Maestro View

The CRi Maestro system is an instrument for fluorescence-based in-vivo molecular imaging. Using multispectral acquisition and analysis, it provides dramatically improved sensitivity, multicolor flexibility and quantitative accuracy for both visible and near-infrared labels.

IVIS Spectrum View

PerkinElmer's IVIS™ Spectrum imaging system The IVIS® Spectrum in vivo imaging system uses a novel patented optical imaging technology to facilitate non-invasive longitudinal monitoring of disease progression, cell trafficking and gene expression patterns in living animals. The IVIS Spectrum is a versatile and advanced in vivo imaging system. An optimized set of high efficiency filters and spectral un-mixing algorithms lets you take full advantage of bioluminescent and fluorescent reporters across the blue to near infrared wavelength region. The system includes a highly sensitive camera, a dark imaging chamber to minimize incident light, and software to quantify the results. The IVIS imaging systems start with a back-thinned CCD camera, designed for high-efficiency photon detection, particularly in the important red region of the spectrum. It can detect very small numbers of photons as well as operate as a traditional camera; displaying images in that wide signal range is a function of the system's Living Image™ software. The CCD is cooled and the electronic readout is optimized so that the data gathered to create the real-time in vivo images have extremely low noise. Up to 5 animals can be imaged at a time and thermoregulation is achieved by means of a heated stage. Inhalable anesthesia is delivered via nose cones throughout the imaging procedure. For advanced fluorescence pre-clinical imaging, the IVIS Spectrum has the capability to use either trans-illumination (from the bottom) or epi-illumination (from the top) to illuminate in vivo fluorescent sources. 3D diffuse fluorescence tomography can be performed to determine source localization and concentration using the combination of structured light and trans illumination fluorescent images. The instrument is equipped with 10 narrow band excitation filters (30nm bandwidth) and 18 narrow band emission filters (20nm bandwidth) that assist in significantly reducing autofluorescence by the spectral scanning of filters and the use of spectral unmixing algorithms. In addition, the spectral unmixing tools allow the researcher to separate signals from multiple fluorescent reporters within the same animal.

MRI

Agilent 7T View

The Center for Molecular Imaging is a leading facility for magnetic resonance imaging (MRI) of animal models. Small animal MR experiments are performed on a state-of-the-art Agilent (formerly Varian) 7 Tesla horizontal bore system. Full physiological monitoring and gating capabilities are available. Animals may be anesthetized using injectable drugs or with a reliable gas delivery system. Thermoregulation is accomplished via a forced air system. A variety of volume and surface coils are available, accommodating samples of many sizes and geometries.


CT

Siemens Inveon View

The Siemens Inveon is a preclinical imaging platform that provides integrated small animal PET/CT imaging and analysis. CT imaging utilizes an 80 W tungsten anode with a maximum resolution of 27 microns. The system is equipped with an inhalable anesthesia system and a heated bed is utilized to maintain constant body temperature.

TriFoil Imaging eXplore SpeCZT View

The TriFoil Imaging eXplore speCZT CT 120 system is a small animal SPECT/CT scanner that is designed to visualize, quantify, and characterize anatomical parameters in small animals such as mice and rats. Its table design, versatile bed mount, and innovative software allow image registration with other imaging modalities. The integrated CT can perform prospectively gated respiratory and cardiac imaging with extremely high precision, to minimize motion artifacts in the heart and thorax. The system includes shielded ports for ventilation tubing, anesthetic gases, or monitoring hardware and is calibrated to the standards of clinical CT systems, using industry-standard image scaling in Hounsfield units. The scanner is fully shielded for laboratory use as a "Cabinet X-ray" device, helping to ensure operator safety without the need for additional room shielding.

Bruker SkyScan View

The SkyScan 1176 is a high performance in vivo micro CT scanner for preclinical research. The large format 11 megapixel x-ray camera gives an unrivalled combination of resolution, image field size and scan speed. Image field width up to 68 mm allows full body mouse and rat scanning. Variable x-ray applied voltage and filters provide scanning flexibility to allow imaging of a wide range of samples from lung tissue to bone. An integrated physiological monitoring subsystem provides breathing and heart-beat gating for proven thoracic image improvement by synchronized acquisition and a dedicated inhalable anesthesia system is in place.

PET

Siemens Inveon View

The Siemens Inveon is a preclinical imaging platform that provides integrated small animal PET/CT imaging and analysis. PET imaging is achieved via a dual-rotating 57Co transmission source with an axial FOV of 12/7 cm and continuous bed motion that effectively extends the axial FOV to 50 cm. The system is equipped with an inhalable anesthesia system and a heated bed is utilized to maintain constant body temperature.

SPECT

TriFoil Imaging eXplore SpeCZT View

The TriFoil Imaging eXplore speCZT CT 120 system is a small animal SPECT/CT scanner with full ring CZT detector technology. The 10 head commercial SPECT detector delivers fast scan times and excellent image resolution and sensitivity.