Use the following links to reach each faculty person's listing on this page. Each listing provides a brief description of the faculty member's research. Use links within each listing to obtain more detailed information.
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Phillip Andrews
Dept Biol Chem
763-3130
andrewsp@umich.edu
http://www.proteome.med.umich.edu/
Our laboratory is very interested in understanding the functional and organizational patterns underlying complex systems, i.e. to relate the proteome to the genome. A major focus has been the development of new technologies for comprehensive analysis of the responses of living cells to their environment at the molecular level, e.g. linking protein structure information to genome sequence. Thus a goal has been to achieve ultra-high throughput analysis of the majority of the proteins present in cells. |
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Peter Arvan
Dept of Internal Medicine
936-5505
parvan@umich.edu
http://www.med.umich.edu/intmed/endocrinology/arvanlab/index.html
We are interested in diseases linked to defects in protein processing and trafficking in the intracellular secretory pathway. This also requires an intimate understanding of the workings of normal protein processing and trafficking pathways. |
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Kate Barald
Dept Cell and Developmental Biology, Biomedical Engineering, PIBS
647-3376
kfbarald@umich.edu
http://www.umich.edu/~eardevel/
http://www.med.umich.edu/cdb/sub_pages/People/barald.htm
http://www.umich.edu/~neurosci/faculty/kfbarald.htm
Molecular and cellular studies of auditory system development and regeneration in the mouse (including transgenic approaches), chick, zebrafish and immortalized inner ear cell lines. Studies of hormonal regulation of the tumor suppressor gene, neurofibromatosis I, using embryonic mouse stem cell approaches. Microfluidic organ cultures of inner ears and zebrafish for studies of morphogenesis.
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James Bardwell
Dept Molecular & Cellular Developmental Biology
764-8028
jbardwel@umich.edu
http://www.mcdb.lsa.umich.edu/labs/bardwell/
Protein folding, disulfide bond formation. |
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Scott Barolo
Dept Cell & Developmental Biology
764-7295
sbarolo@umich.edu
http://sitemaker.umich.edu/barolo
My lab studies the mechanisms by which transcriptional enhancers control gene expression during development, using genetic, biochemical, evolutionary, and bioinformatics approaches. We focus on enhancers that are directly regulated by cell signaling pathways, including Hedgehog, Wnt, Notch, and MAPK, all of which play important roles in development and disease. |
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Keith Bishop
Dept Surgery
763-0326
kbishop@umich.edu
http://www.med.umich.edu/microbio/bio/bishop.htm
Our research is focused on identifying key regulatory events that influence T cell mediated immunity in vivo. This includes an analysis of cytokine regulation of effector cell development and the functional activities of T cells that culminate in tissue damage. |
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Daniel Bochar
Dept Biological Chemistry
647-3734
dbochar@umich.edu
http://bochar.biochem.med.umich.edu/
Regulation of eukaryotic gene expression through the modulation of chromatin structure and the connection to developmental disorders and cancer. |
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Jimo Borjigin
Dept Mol. Integ. Physiology
763-5453
borjigin@umich.edu
http://www.umich.edu/~neurosci/faculty/borjigin.htm
The first focus of my lab is to investigate the properties of the central pacemaker by studying the melatonin output, the hands of the circadian clock, under normal and perturbed conditions. The second focus of my lab is to study how circadian rhythms of melatonin production are regulated within the pineal gland. |
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Thomas Brock
Dept Internal Medicine
936-5203
brocko@umich.edu
Pumonary & Critical Care Medicine
Molecular and cellular aspects of cell-to-cell communication by polyunsaturated fatty acids, particularly in the contexts of immune defense and pathology. In particular, we use molecular, cellular, biochemical, structural and computational analyses to study the regulation of enzymes that convert fatty acids into alternative lipid mediators.
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Charles Burant
Dept Internal Medicine/Mol. Integ. Physiol
615-3481
burantc@umich.edu
Growth and differentiation of tissues in diabetes. Metabolomics in type 2 diabetes. |
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Margit Burmeister
Dept Human Genetics, Psychiatry
647-2186
margit@umich.edu
http://www.mbni.med.umich.edu/mbni/faculty/burmeister/burmeister.html
We are interested in the identification and functional understanding of genes involved in behavior, neurological and psychiatric disorders. |
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Ezra Burstein
Dept Internal Medicine
647-9853
ezrab@umich.edu
http://www.med.umich.edu/gi/staff/burstein/index.htm
Dr. Burstein's laboratory studies the function of a novel set of NF- k B regulators called COMMD proteins, which are characterized by unique structural and functional characteristics. The laboratory's efforts are centered in understanding the mechanism by which COMMD proteins inhibit NF- k B, their role in regulating inflammatory responses in vivo, and their participation in the regulation of other transcription factors. |
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Kenneth Cadigan
Dept Molecular & Cellular Developmental Biology
936-3246
cadigan@umich.edu
Molecular, Cellular, Developmental Biology
We study Wnt signal transduction in Drosophila, focusing on the mechanism by which this conserved pathway regulates transcription. We also work on the control of apoptosis in rapidly growing tissues. |
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Sally Camper
Dept Human Genetics
763-0682
scamper@umich.edu
http://www.hg.med.umich.edu/labs/camperlab/index.html
Birth defects research, organogenesis, mouse models of human disease growth insufficiency including hormonal and skeletal dysplasia, hearing and vestibular dysfunction. |
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Thomas Carey
Dept Otolaryngology/Head and Neck Surgery; Periodontics and Oral Medicine; Pharmacology
764-4371
careyte@umich.edu
http://www.khri.med.umich.edu/research/carey_lab/index.php
We study autoimmune hearing loss with emphasis on identification of antigenic targets of pathogenic antibodies. We also study genetic changes associated with cancer progression, signaling through galanin and its receptors, and identifying and overcoming mechanisms of resistance to chemotherapy in head and neck cancer. |
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Gregory Cartee
Dept Kinesiology
763-2561
gcartee@umich.edu
http://www.kines.umich.edu/faculty/full-time/cartee.html
We study the regulation of skeletal muscle metabolism, especially the influence of exercise/contraction on glucose transport. |
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Christin Carter-Su
Dept Mol. Integ. Physiol
763-2561
cartersu@umich.edu
http://www.physiology.med.umich.edu/research/profiles/cartersu.htm
Signal transduction pathways used by cytokine receptors and JAK tyrosine kinases; molecular actions of growth hormone; role of SH2-B adapter proteins in regulation of the cytoskeleton, gene expression and cellular differentiation and survival. |
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Raymond Chan
Dept Human Genetics, Internal Medicine
615-5393
rchan@umich.edu
http://www.umich.edu/~mmgmed/faculty/bios/Chan.htm
Our lab studies how higher-order chromosome structures are established and maintained using the model organism Caenorhabditis elegans. In particular, we are focused on the function and regulation of the Structural Maintenance of Chromosome (SMC) protein family in organizing and packaging chromosomes and maintaining genomic stability. |
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Amy Chang
Dept Molecular & Cellular Developmental Biology
647-7964
amychang@umich.edu
http://www.biology.lsa.umich.edu/research/labs/chang/chang.htm
We are working on protein sorting and quality control in the yeast secretory pathway. |
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Cheong-Hee Chang
Dept
Microbiology and Immunology
763-3531
heechang@umich.edu
http://www.med.umich.edu/microbio/bio/chchang.htm
The research program in my laboratory has been focusing on investigating and understanding the molecular mechanisms that govern the adaptive immune function. Currently, two areas of research are ongoing: CD4 T cell development and effector function, and the cytokine network of dendritic cells. |
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Yuqing Chen
Dept Internal Medicine
936-3500
echenum@umich.edu
The Role of Nuclear Receptors in Obesity/Diabetes-Related Cardiovascular Complications. |
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Arul Chinnaiyan
Dept Michigan Center for Translational Pathology
615-4062
arul@umich.edu
http://www.pathology.med.umich.edu/chinnaiyan
Dr. Chinnaiyan's laboratory has focused on functional genomic,proteomic and bioinformatics approaches to study cancer for the purposesof understanding cancer biology as well as to discover clinicalbiomarkers. He and his collaborators have characterized a number ofbiomarkers of prostate cancer including AMACR, EZH2 and hepsin. AMACRis being used clinically across the country in the assessment of cancerin prostate needle biopsies. |
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Kathleen Collins
Dept Internal Medicine/Micro & Imm
klcollin@umich.edu
http://www.med.umich.edu/microbio/bio/collins.htm
http://www.med.umich.edu/immprog/faculty/collinsk.htm
http://www.med.umich.edu/genetics/faculty/collins.htm
http://www.med.umich.edu/intmed/infectious/staff/index.htm
Molecular Mechanisms of HIV Disease Pathogenesis. |
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Mark Day
Dept Urology
763-9968
mday@umich.edu
Proteolytic processing of tumor cells in prostate cancer metastasis. Regulation of novel E2F1 target genes following disruption of the Rb/E2F pathway in human cancer. |
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Victor DiRita
Dept ULAM/Micro & Imm
936-3804
vdirita@umich.edu
http://www.med.umich.edu/microbio/bio/dirita.htm
My lab studies the biology and pathogenicity of Vibrio cholerae and Campylobacter jejuni, two diarrheal pathogens of humans. Our work focuses in particular on membrane-associated mechanisms that regulate a variety of processes in these microbes. |
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Andrzej Dlugosz
Dept Dermatology
647-9482
dlugosza@umich.edu
http://myprofile.cos.com/dlugosza
http://www.med.umich.edu/derm/faculty/dlugosza.shtml
Embryonic signaling pathways in development, regeneration, and neoplasia. |
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Steven Domino
Dept Ob/Gyn
647-9562
sedomino@umich.edu
http://www.med.umich.edu/obgyn/staff/
Carbohydrate-containing glycoconjugates decorate virtually every cell in the body. The long-term objective of my research is to define the functions of cell-surface carbohydrates in reproductive tissues and cancers, potentially leading to new treatments based on carbohydrate-protein interactions. |
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Gregory Dressler
Dept Pathology
764-6490
dressler@umich.edu
http://www.pathology.med.umich.edu/dresslerlab/
My lab studies the molecular basis of embryonic development using the mammalian kidney as a model system. Transcription factors and cell signaling pathways are studied at the genetic and biochemical level to understand how extrinsic signals lead to intrinsic cell lineage specification, differentiation, and proliferation. How developmental regulatory pathways contribute to renal disease is also of interest. |
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Cunming Duan
Dept Molecular Cellular & Developmental Biology
763-4710
cduan@umich.edu
Molecular, Cellular, Developmental Biology
Our lab uses the zebrafish and cultured mammalian cells as model systems to study the roles of growth factor signaling pathways in regulating cell proliferation, differentiation, and apoptosis in development. |
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Colin Duckett
Dept Pathology/Internal Medicine
615-6414
colind@umich.edu
http://web.mac.com/csd66/iWeb/lab/Home.html
Our group is primarily focused on the pathogenesis of cancer. We are particulary interested in the IAP ( Inhibitor of Apoptosis) family of genes, which are thought to promote oncogenesis through a wide variety cellular roles, including the regulation of cell death, cell cycle control, activation of kinase pathways, protein degradation and copper homeostasis. |
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Daniel Eitzman
Dept Internal Medicine
936-7838
deitzman@umich.edu
http://www.med.umich.edu/intmed/
Our lab focuses on the genetic determinants of thrombosis, atherosclerosis, and inflammation. |
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Dorraya El-Ashry
Dept
Int Med-Hematology/Oncology
764-5585
elashryd@umich.edu
http://sitemaker.umich.edu/el-ashry/home
Estrogen action and growth factor initiated signal transduction in breast cancer progression, mechanisms of anti-estrogen resistance, and novel therapeutics. |
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James T. Elder
Dept Dermatology/Radiation Oncology
763-0355
jelder@umich.edu
http://www.psoriasis.umich.edu
http://www.med.umich.edu/derm/faculty/jelder.shtml
Our laboratory is interested in molecular mechanisms controlling epidermal growth and differentiation, including how this process is linked to host defense and autoimmunity. For this purpose, we utilize cell biology, organ culture, transgenic animals, genetic linkage analysis, and gene expression profiling. |
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J. Douglas Engel
Dept Cell & Developmental Biology
615-7509
engel@umich.edu
http://www.med.umich.edu/cdb/sub_pages/People/engel.htm
Our lab exploits mouse genetics to explore the molecular basis of human disease. We are examining the consequences of targeted loss of function (traditional and conditional knockouts) and gain of function (conventional and BAC transgenics) to understand the developmental regulation of several transcription factors we have cloned over the years (GATA-2, GATA-3, small Mafs and the TR2 and TR4 orphan nuclear receptors), and to unravel their distinct contributions organogenesis. |
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David Engelke
Dept Biological Chemistry
763-0641
engelke@umich.edu
http://www2.ritc.med.umich.edu/?q=engelke
Regulation of eukaryotic gene expression at the levels of transcription and RNA processing; structure and function of complex catalytic RNA, spatial genomics. |
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Eric Fearon
Dept Internal Medicine/Human Genetics
764-1549
fearon@umich.edu
Cancer genetics, gastrointestinal cancer, oncogenes, tumor suppressor genes, beta-catenin, Wnt signaling, developmental biology, CDX2, E-cadherin. |
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Eva Feldman
Dept Neurology
763-7274
efeldman@umich.edu
http://www.med.umich.edu/pfund/
The role of growth factors in the pathogenesis and treatment of neurologic disorders. |
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David Ferguson
Dept Pathology
764-4591
daviferg@umich.edu
http://www.pathology.med.umich.edu/fergusonlab/
DNA Repair and Genomic Stability in Mammals. We study how DNA repair prevents cancer, controls development of the immune system, and ensures proper overall mammalian development. |
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Renny Franceschi
Dept Dentristry/Perio-Prev & Geriatrics/Biol Chem
763-7381
rennyf@umich.edu
http://www2.ritc.med.umich.edu/?q=franceschi
Signals regulating the formation and functioning of osteoblasts, the cells that produce and mineralize the extracellular matrix of bone; gene therapy approaches for regeneration of mineralized tissues. |
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Robert Fuller
Dept Biological Chemistry
936-9764
bfuller@umich.edu
http://www2.ritc.med.umich.edu/?q=fuller
http://www.chembio.umich.edu/people/fuller.html
My laboratory studies protein localization and processing in the eukaryotic secretory pathway. |
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Philip Gage
Dept Ophthalmology & Visual Sciences
647-4215
philgage@umich.edu
http://www.med.umich.edu/cdb/sub_pages/People/gage.htm
The goal of our laboratory is to understand the molecular mechanisms underlying normal and abnormal mammalian eye development. The approaches we employ include mouse models, functional genomics, and cell culture systems. |
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Sonja Gerrard
Dept
School of Public Health, Epidemiology
615-8491
gerrard@umich.edu
http://www.sph.umich.edu/iscr/faculty/profile.cfm?uniqname=gerrard
http://www.med.umich.edu/microbio/bio/gerrard.html
Replication and assembly of negative-strand RNA viruses. Genetic basis of viral pathogenicity and virulence. |
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David Ginsburg
Dept HHMI/Internal Medicine/Human Genetics
647-4808
ginsburg@umich.edu
http://www.hhmi.org/research/investigators/ginsburg.html
http://www.lifesciences.umich.edu/institute/labs/ginsburg/index.html
David Ginsburg is interested in understanding the components of the blood-clotting system and how disturbances in their function lead to human bleeding and blood-clotting disorders. |
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Thomas Glover
Dept Human Genetics/Pediatrics
763-5222
glover@umich.edu
Molecular cytogenetics and the molecular biology of human disease. |
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Jun-Lin Guan
Dept Internal Medicine
615-4936
jlguan@med.umich.edu
http://www.umich.edu/~mmgmed/faculty/bios/Guan.htm
The goals of our research programs are to understand fundamental principles of cell signaling in the regulation of basic cellular functions in normal cell and developmental processes and to determine how disruption of the normal signaling pathways either by genetic mutations or environmental insults may lead to diseases such as cancer. |
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Kun Liang Guan
Dept Biological Chemistry/Gerontology
763-3030
kunliang@umich.edu
http://www.lifesciences.umich.edu/institute/labs/guan/index.html
Regulation and function of the TSC-mTOR pathway in cell growth, cell size, and cell survival. |
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Deborah Gumucio
Dept Cell & Developmental Biology
647-0172
dgumucio@umich.edu
http://www-personal.umich.edu/~dgumucio/
http://www.med.umich.edu/cdb/
http://www.med.umich.edu/medschool/organo/
http://www.bioartography.com
Organogenesis of the small intestine (molecular biology, cell biology, developmental biology). Molecular etiology of familial Mediterranean fever (molecular biology, cell biology, pathobiology) |
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Gary Hammer
Dept Internal Medicine/Mol. Integ. Physiol
936-5033
ghammer@umich.edu
http://www.med.umich.edu/hammerlab/
Mechanisms by which signaling and transcriptional programs initiate growth and differentiation of adrenocortical stem cells with an emphasis on dysregulated growth in adrenal development and cancer. |
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Jay Hess
Dept Pathology
763-6384
jayhess@umich.edu
My laboratory studies mechanisms of transformation by the mixed lineage leukemia protein MLL, which is commonly rearranged in both acute lymphoid and myeloid leukemias. |
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Joseph Holoshitz
Dept Internal Medicine
764-5470
jholo@umich.edu
The research theme of Dr. Holoshitz’ laboratory is the role of signal transduction events in health and disease. |
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Ronald Holz
Dept Pharmacology
764-2267
holz@umich.edu
http://sitemaker.umich.edu/holz.lab
Mechanisms of neurotransmitter and hormone secretion; membrane permeability. |
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Lawrence Holzman
Dept Internal Medicine
764-3157
lholzman@umich.edu
Mechanisms that govern JNK signaling function, specificity and activity. Podocyte cell biology; molecular integration of junctional and cytoskeletal dynamics. |
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Patrick Hu
Dept Int Med/CDB
615-9656
pathu@umich.edu
http://lsi.umich.edu/facultyresearch/labs/hu
The Hu lab uses the nematode C. elegans as a model system for studying evolutionarily conserved signal transduction pathways that are dysregulated in cancer and diabetes, with the eventual goal of generating hypotheses that can be tested in mouse models of human disease. |
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Michael Imperiale
Dept Microbiology & Immunology
763-9162
imperial@umich.edu
http://www.sitemaker.umich.edu/imperiale.lab
Our lab studies the molecular biology of small DNA tumor viruses, including how they interact with the host immune reponse, how they assemble, and how the cause ongogenic transformation. We are also interested in their use as gene therapy vectors. |
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Lori Isom
Dept Pharmacology
936-3050
lisom@umich.edu
http://sitemaker.umich.edu/lisom.lab
The goal of our research is to test the hypothesis that beta subunits of voltage-gated Na+ channels (VGSCs) are cell adhesion molecules (CAMs) that communicate between extra- and intra-cellular signaling and cytoskeletal proteins. |
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Ursula Jakob
Dept Molecular Cellular & Development Biology
615-1286
ujakob@umich.edu
http://www.lsa.umich.edu/mcdb1/faculty/ujakob/lab/index.html
Oxidative stress and redox regulation.
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Yvonne Kapila
Dept Periodontics and Oral Medicine
615-2295
ykapila@umich.edu
My lab focuses on three main areas of research. One area involves understanding the underlying cell-matrix interactions that govern disease progression in inflammatory diseases such as periodontal tissues. These studies encompass both basic cell and molecular biology studies and patient/translational investigations. Another related area that our lab has recently embarked on relates to expanding our understanding of the mechanisms by which matrix metalloproteinases (MMPs) triggered by inflammatory disease-modulated-matrices may enhance osteoclast activity and diminish osteoblast differentiation. Lastly, the other main area of research in my lab involves understanding the cell-matrix interactions that govern cell survival and invasion/migration of squamous cell carcinomas. |
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Catherine Keegan
Dept. Pediatrics-Genetics
647-8237
keeganc@umich.edu
http://sitemaker.umich.edu/keeganlab
We are interested in the role of telomeric proteins in maintaining genomic stability during development. We are currently studying the adrenocortical dysplasia(acd) mutant mouse as a model for birth defects that are caused by telomere dysfunction. We also have an interest in mouse models of human congenital malformations of the urogenital system and caudal region.
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Evan Keller
ULAM/Dept Pathology
615-0280
etkeller@umich.eduwww.umich.edu/~etklab
Our laboratory studies the biology of prostate cancer skeletal metastases through a variety of methods. Our current work focuses on examining bone morphogenetic proteins (BMPs) that work through SMAD transcription factors, exploring a signal transduction factor that diminishes prostate cancer metastases, and investigating how interleukin-6 stimulates the androgen receptor in prostate cancer cells. |
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John Kim
Dept Human Genetics
615-9915
jnkim@umich.edu
http://www.lsi.umich.edu/facultyresearch/labs/kim
We study the function of microRNAs and RNAi mechanisms in C. elegans and cell culture systems. |
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Daniel Klionsky
Dept Molecular Cellular & Developmental Biology
615-6556
klionsky@umich.edu
http://www.lifesciences.umich.edu/institute/labs/klionsky/index.html
http://www.biology.lsa.umich.edu/research/labs/klionsky/klionskylab.html
My lab studies protein targeting and autophagy using the model system baker's yeast. We are a cell biology lab that utilizes molecular, biochemical and genetic techniques to address fundamental questions concerning protein and membrane biosynthesis and organelle biogenesis. |
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Ronald Koenig
Dept Internal Medicine
763-3056
rkoenig@umich.edu
http://sitemaker.umich.edu/KoenigLab
Research is focused in the following areas: 1) the role of a Pax8-PPARgamma fusion protein (caused by a chromosomal translocation) in the development of thyroid cancer; 2) the function of thyroid hormone receptor alpha-2, an alternative splice product of the thyroid hormone receptor alpha transcript that does not bind thyroid hormone but that binds RNA; 3) the role of selenoproteins in protecting against oxidative stress in diabetes; and 4) the roles of retinoic acid and BMP4 in inner ear development and function. |
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Catherine Krull
Dept Cell & Developmental Biology
615-7509
krullc@umich.edu
www.med.umich.edu/cdb/sub_pages/People/krull.htm
We are interested in the cellular interactions and molecular mechanisms that direct migratory cells to their target regions during embryonic development. |
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Steven Kunkel
Dept Pathology
764-4460
slkunkel@umichl.edu
Experimental research activities directed at understanding the cellular and molecular mechanisms of cytokine networks that are operative in different immune/inflammatory reactions and host defenses represent the major research efforts in the laboratory. |
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John Kuwada
Dept Molecular Cellular & Developmental Biology
936-2842
Kuwada@umich.edu
http://www.mcdb.lsa.umich.edu/labs/kuwada/
We are interested in identifying and understanding genes that regulate the formation and function of neural circuits in the vertebrate CNS. |
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Daniel Lawrence
Dept Internal Medicine
763-7838
dlawrenc@umich.edu
http://sitemaker.umich.edu/lawrence.lab/home
Understanding how fundamental binary protein; protein interactions regulate complex physiologic processes. |
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Theodore Lawrence
Dept Radiation Oncology
647-9955
tsl@umich.edu
http://www.sitemaker.umich.edu/TLawrence
Drug-Radiation Interactions and Gene Therapy. |
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Angel Lee
Dept Pharmacology
647-6004
awmlee@umich.edu
http://sitemaker.umich.edu/awmlee
Signal transduction mechanisms that regulate cell growth, survival and differentiation of myeloid lineage cells and neural stem cells. |
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Andrew Lieberman
Dept Pathology
615-3860
liebermn@med.umich.edu
Study of the mechanisms of neurodegeneration in CAG/polyglutamine disorders and Niemann- Pick C using mouse and cellular models. Our goal is understand disease pathogenesis and define novel targets for treatment. |
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Jiandie Lin
CDB
615-3512
jdlin@umich.edu
http://www.lifesciences.umich.edu/institute/labs/lin/index.html
http://www.med.umich.edu/cdb/sub_pages/People/lin.htm
The Lin lab is investigating the mechanisms that regulate mitochondrial function, in particular transcriptional circuitry that controls mitochondrial biogenesis and energy metabolism. Their studies will lead to the discovery of novel targets for the treatment of neurodegeneration, type 2 diabetes, and cardiovascular disease. |
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Yang Liu
Dept Surgery
615-3158
yangl@umich.edu
http://www.med.umich.edu/immprog/faculty/Liu.htm
My laboratory studies the overlapping area of immunology, cancer biology and autoimmune diseases. We are interested in genetic control of cancer and autoimmune diseases, cell surface interactions critical for T cell activation and autoimmunity, and interaction between cancer cells and immune and hematopoietic system. |
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Mats Ljungman
Dept Radiation Oncology
764-3330
ljungman@umich.edu
http://sitemaker.umich.edu/ljungman.lab
Mechanisms of activation of DNA damage signaling, Molecular targets for sensitization of cancer cells to radiation and chemotherapy. |
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Peter Lucas
Dept Path
764-8509
plucas@umich.edu
Research Description Forthcoming... |
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Ormond MacDougald
Dept Mol. Integ. Physiol
647-4880
macdouga@umich.edu
http://www-personal.umich.edu/~macdouga/MacDougaldLab.html
Regulation of adipocyte differentiation and metabolism. Mechanisms by which Wnt signaling regulates cell fate. |
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Jill Macoska
Dept Urology
764-8428
jcoska@umich.edu
http://www.med.umich.edu/urology/research/molecular_genetics.htm
http://www.michiganmicroarray.com
Our research seeks to elucidate the role of paracrine interactions between epithelial and associated stromal cells during tumorigenesis, and the elucidation of specific signaling mechanisms in epithelial cells that are activated or inactivated by stromal-secreted proteins. We are particularly interested in determining how growth factors secreted by aging stromal fibroblasts stimulate epithelial cell proliferation, motility, and malignant transformation in the prostate. |
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Ivan Maillard
Dept Int Med-Hematology/Oncology
763-3599
imaillar@umich.edu
http://lsi.umich.edu/facultyresearch/labs/maillard
The Maillard lab investigates the interaction of blood-forming stem cells with their environment, using the mouse as a model organism. Another interest of the laboratory is in the regulation of peripheral T cell homeostasis and function by Notch signaling. |
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Benjamin Margolis
Dept Biological Chemistry/Internal Medicine
764-3567
bmargoli@umich.edu
http://www2.ritc.med.umich.edu/?q=margolis
Our laboratory studies the role of protein complexes in epithelial cell polarization and ciliogenesis. |
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David Markovitz
Dept Internal Medicine
936-3844
dmarkov@umich.edu
Interaction between retroviruses and human cellular proteins. Mechanism of action of the DEK oncoprotein. Role of vimentin in immunity and cancer. Kaposi’s Sarcoma. |
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Jeffrey Martens
Dept Pharmacology
615-9026
martensj@umich.edu
http://sitemaker.umich.edu/martens
Ion channel/lipid interactions targeting and localization of ion channels. |
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Miriam Meisler
Dept Human Genetics
763-5546
meislerm@umich.edu
http://www.hg.med.umich.edu/labs/meislerlab/
We are studying the molecular basis of neurological disorders using mouse models of epilepsy, movement and behavioral disorders. This work has enabled us to identify several human disease mutations. |
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Ram Menon
Dept Pediatrics
764-5175
rammenon@umich.edu
Research efforts are focused on the development of diabetic kidney disease and understanding the mechanisms underlying the role of growth hormone in the causation of certain chronic complications of type 1 diabetes mellitus. |
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Sofia Merajver
Dept Internal Medicine
764-0228
smerajve@umich.edu
Molecular genetics of aggressive breast cancer phenotypes and hereditary breast cancer. Angiogenesis, molecular therapeutics. |
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Juanita Merchant
Dept Internal Medicine/Mol. Integ. Physiol
647-2944
merchanj@umich.edu
http://www.physiology.med.umich.edu/research/profiles/merchanj.htm
http://sitemaker.umich.edu/differentiation.gi.tract
http://www.med.umich.edu/gi/
Department of Internal medicine: Gastroenterology
Dr. Merchant's primary research interests include transcriptional control mechanisms regulating cell growth and differentiation and microbial-host interactions in the upper GI tract. Applications of her work involve the role of inflammation in the stomach, the development of peptic ulcers and gastrointestinal cancer. |
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Joseph Metzger
Dept Mol. & Integ. Physiol/Internal Medicine
763-0560
metzgerj@umich.edu
http://www-personal.umich.edu/~metzgerj
Molecular and Systems Biology of the Heart; Cardiac transgenesis; Molecular mechanisms of contraction in skeletal and cardiac muscle; Experimental gene and cell therapies for the failing heart. |
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Edgar Meyhofer
Dept Mechanical Engineering
647-7856
meyhofer@umich.edu
http://www.umich.edu/~nanomech/
Kinesin, biomolecular motors, molecular sorting. |
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Dan Michele
Dept Molecular and Integrative Physiology
764-5738
dmichele@umich.edu
http://sitemaker.umich.edu/michelelab
Molecular mechanisms of muscular dystrophy and inherited cardiomyopathies |
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David Miller
Dept Internal Medicine
763-0565
milldavi@umich.edu
http://sitemaker.umich.edu/millerlab
Cellular and molecular mechanisms of viral RNA replication and the innate immune response to viral infections. |
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Richard Miller
Dept Pathology
936-2122
millerr@umich.edu
http://www.pathology.med.umich.edu/faculty/Miller/index.html
Rich Miller's laboratory studies the control of aging in mice, with current emphasis on genetic control of the rate of aging and the relationship between cellular stress resistance and disease resistance in long-lived mice. |
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John Moran
Dept Human Genetics
615-0456
moranj@umich.edu
http://www.hg.med.umich.edu/facultyprofile.php?id=21
http://www.umich.edu/~mmgmed/faculty/moran/moran2.html
We are interested in how transposable elements have impacted the human genome. |
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Sean Morrison
Dept Cell & Developmental Biology/Internal Medicine
647-6261
seanjm@umich.edu
http://www.lsi.umich.edu/facultyresearch/labs/morrison
We study mechanisms that regulate stem cell function in the hematopoietic and nervous systems. We have chosen to focus on the mechanisms that regulate stem cell self-renewal, stem cell aging, and cancer cell proliferation in these tissues. |
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Richard Mortensen
Dept Internal Medicine/Mol. Integ. Physiol
763-2021
rmort@umich.edu
http://sitemaker.umich.edu/mortensenlab
Molecular Mechanisms of Insulin Resistance, inflammation, metabolic disorders and associated cardiovascular disease. |
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Martin Myers
Dept Internal Medicine, Molecular and Integrative Physiology
647-9515
mgmyers@umich.edu
http://www.med.umich.edu/diabetes/research/profilesMyers1.html
http://www.med.umich.edu/intmed/endocrinology/myerslab/index.html
Dr. Myers’ research focuses on the processes that enable the body to respond normally to insulin, and how problems in these pathways contribute to the development of insulin resistance and diabetes. His laboratory specifically concentrates on the crucial role played by nerve centers in the unconscious part of the brain – what Myers calls “glycemic control centers”- that regulate the body’s ability to respond to insulin. |
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Gabriel Nunez
Dept Pathology
764-8514
bclx@umich.edu
http://www.pathology.med.umich.edu/faculty/Nunez/index.html
Role of Innate Immunity in Host Defense and Cancer |
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Laura Olsen
Dept Molecular Cellular & Developmental Biology
763-0976
ljo@umich.edu
http://www.biology.lsa.umich.edu/faculty/labs/olsen/
We study two important areas of cell biology - peroxisome biogenesis and stress-induced autophagy. |
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Akira Ono
Dept Microbiology and Immunology
615-4407
akiraono@umich.edu
http://www.med.umich.edu/microbio/bio/ono.htm
http://sitemaker.umich.edu/ono.lab/home
Our lab studies the relationships between cellular structures and enveloped viruses. We are particularly interested in the roles played by cellular membranes during the life cycle of HIV-1. |
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Henry Paulson
Dept Neurology
615-5632
henryp@umich.edu
http://www.med.umich.edu/neuro/faculty/paulson.htm
Departmental Listing
Polyglutamine neurodegenerative disease; Spinocerebellar Ataxia type 3; RNA interference as potential therapy including studies of polyglutamine diseases and Alzheimer's disease; Protein quality control in normal brain function in disease. |
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Elizabeth Petty
Dept Internal Medicine/Human Genetics
763-2532
epetty@umich.edu
Department of Internal Medicine
Molecular genetic mechanisms underlying tumorigenesis roles of novel cancer genes and cell cycle checkpoint genes; clinical genetics: cost-effect and ethical application of molecular genetic tests in medicine. |
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Kenneth Pienta
Dept Internal Medicine
647-3421
kpienta@umich.edu
Our laboratory focuses on gaining insight into the biologic mechanisms underlying prostate cancer metastasis. These insights have been used to identify novel targets for the treatment of advanced prostate cancer, thus successfully moving bench research into the clinic in the form of Phase II and Phase III clinical trials. |
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Malini Raghavan
Dept Microbiology & Immunology
647-7752
malinir@umich.edu
http://sitemaker.umich.edu/raghavan.lab
The binding of complexes of peptides and major histocompatibility complex (MHC) class I molecules to T cell receptors is of fundamental importance for the recognition of virally infected cells by T cells. Our major interest is in the MHC class I antigen processing pathway, the cellular pathway by which complexes of peptides and MHC class I molecules are generated. We study specific components of this pathway, including the transporter associated with antigen processing (TAP), tapasin, calreticulin, and ERp57. TAP transports peptides from the cytosol to the endoplasmic reticulum (ER) for binding to class I MHC molecules, and tapasin is an ER-resident MHC class I-specific assembly factor. Calreticulin is a generic ER chaperone, and ERp57 is a thiol-disulfide isomerase. Our goal is to understand how these proteins interact and function to orchestrate MHC class I assembly in the ER. We use molecular biology and biochemical techniques to generate desired proteins in heterologous systems. We investigate mechanisms of function using biochemical, biophysical, and cell biological approaches.
Multiple genes encode MHC class I proteins, and each gene is highly polymorphic across the population. Closely related MHC class I molecules have dramatically different intracellular trafficking rates, which could have profound functional consequences during infection. Recent genetic studies have shown that closely related MHC class I allotypes are associated with different rates of AIDS progression. Some of our current work is directed at understanding the molecular basis for these reported differences. |
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Stephen Ragsdale
Dept Biological Chemistry
647-9515
sragsdal@umich.edu
http://www2.ritc.med.umich.edu/?q=ragsdale
Research description to come... |
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Alnawaz Rehemtulla
Dept Radiation Oncology
764-4209
alnawaz@umich.edu
Non-invasive detection of molecular events in live animals (Molecular Imaging). |
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Diane Robins
Dept Human Genetics
764-4563
drobins@umich.edu
http://www.hg.med.umich.edu/facultyprofile.php?id=24
We study hormone-regulated gene expression, from basic mechanisms of androgen receptor action to steroid-dependent cancer (prostate and breast), in mouse models and in vitro. Additionally, we study transcriptional repression in sexually dimorphic liver gene expression, focusing on genome evolution and reproductive biology. |
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Theodora Ross
Dept Internal Medicine
615-5509
tsross@umich.edu
http://sitemaker.umich.edu/rosslab
Our lab studies signaling pathways and transcription factor networks that control the formation and differentiation of neural stem and progenitor cells during embryonic development.
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Liangyou Rui
Dept Mol. & Integ. Physiol
763-5727
ruily@umich.edu
http://www.physiology.med.umich.edu/research/profiles/ruily.htm
Cell signaling and molecular mechanism of obesity and type 2 diabetes. |
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Mark Russell
Department of Pediatrics & Communicable Diseases
936-8663
mruss@umich.edu
http://sitemaker.umich.edu/mwrussell.lab/home
Dr. Russell is studying mechanisms of cardiac and skeletal myofibril assembly, alignment and structural support, topics central to the pathophysiology of, and development of new therapies for, heart failure, myopathy and muscular dystrophy. His laboratory is currently using cell culture as well as mouse and zebrafish model systems to determine the functions of a novel pair of genes, obscurin and obscurin-like 1, that have been cloned and characterized in his laboratory. |
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Alan Saltiel
Dept Internal Medicine/Mol. Integ. Physiol
615-9787
saltiel@umich.edu
http://lsi.umich.edu/facultyresearch/labs/saltiel
New Pathways in Disorders of Glucose and Lipid Metabolism. |
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Linda Samuelson
Dept Mol. Integ. Physiol
764-9448
lcsam@umich.edu
http://www.physiology.med.umich.edu/research/profiles/lcsam.htm
Research in the Samuelson lab is focused on the development and physiology of gastrointestinal tissues. Specific topics include mechanisms regulating gastric acid secretion, cellular differentiation of cells in the stomach and intestine, function of the gastrointestinal hormones gastrin and CCK, gut endocrine cell development, and parietal cell biology. |
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John Schiefelbein
Dept Molecular Cellular & Developmental Biology
764-3580
schiefel@umich.edu
http://www.mcdb.lsa.umich.edu/labs/schiefel/
Our lab is interested in the molecular mechanisms that regulate cell fate. We use molecular, genetic, cellular, and bioinformatics approaches to address basic questions concerning the specification of distinct cell identities during the development of multicellular organisms. |
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Jessica Schwartz
Dept Mol. & Integ. Physiol
647-2124
jeschwar@umich.edu
http://www.physiology.med.umich.edu:16080/faculty/schwartz/
Regulation of gene transcription and transcription complexes by growth hormone and related growth factors; growth hormone signaling to the nucleus; bioinformatics analysis of genes for insulin resistance. |
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Audrey Seasholtz
Dept Biological Chemistry
936-2072
aseashol@umich.edu
http://www2.ritc.med.umich.edu/?q=seasholtz
http://www.umich.edu/~neurosci/faculty/aseashol.htm
Molecular mediators of stress and anxiety; regulation and role of CRH, the CRH receptors and CRH-binding protein in stress; mechanisms of transcriptional regulation; transgenic mice. |
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Maria Soengas
Dept Dermatology
936-5643
soengas@umich.edu
http://www.med.umich.edu/derm/faculty/soengas.shtml
Tumor suppressor mechanisms in the skin. Molecular basis of melanoma progression and chemoresistance. |
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Katherine Spindler
Dept Microbiology & Immunology
615-272
krspin@umich.edu
http://www.med.umich.edu/microbio/bio/spindler.htm
http://www.sitemaker.umich.edu/spindlerlab
Molecular biology and pathogenesis of virus-host interactions; genetic basis of host susceptibility to infection; mouse adenovirus type 1 and Punta Toro virus. |
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Yi Sun
Dept Radiation Oncology
615-1989
sunyi@umich.edu
http://sitemaker.umich.edu/sunyi
The main focus of Dr. Yi Sun’s laboratory is to understand the molecular mechanism and signaling pathways in apoptosis regulations with an ultimate goal to identify and validate drug targets for mechanism-driven anti-cancer drug discovery. |
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Roger Sunahara
Dept Pharmacology
647-6277
sunahara@umich.edu
http://sitemaker.umich.edu/sunahara/
My laboratory is interested in the delineation of the mechansim of
activation of the G protein coupled receptor signaling pathway. We use
biochemical and biophysical approaches to study both the structure and
function initiating at the hormone-receptor binding event. |
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Joel Swanson
Dept Microbiology & Immunology
647-6339
jswan@umich.edu
http://www.umich.edu/%7Ejswanlab/
Regulation of endocytosis and phagocytosis in macrophages. |
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Michele Swanson
Dept Microbiology & Immunology
647-7295
mswanson@umich.edu
http://www.med.umich.edu/microbio/mswanson.html
http://myprofile.cos.com/mswanson98
Mechanisms that determine the fate of particles ingested by macrophages, using the genetically-tractable bacterial pathogen Legionella pneumophila as a model system to study macrophage cell biology. |
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Anand Swaroop
Dept Human Genetics/Ophthalmology & Visual Sciences
615-2246
swaroop@umich.edu
http://www.umich.edu/~retina/
Molecular, genetic and cellular pathways underlying development of retinal neurons, microtubule-based intracellular transport, and pathogenesis of retinal degenerative diseases consitute the major areas of our research. |
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Alice Telesnitsky
Dept Microbiology & Immunology
936-6466
ateles@umich.edu
http://sitemaker.umich.edu/telesnitsky.lab
Retroviral genetic variation and intracellular RNA trafficking. |
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Robert Thompson
Dept Psychiatry
615-3117
mutant@umich.edu
http://www2.med.umich.edu/psychiatry/psy/fac_query4.cfm?link_name=Thompson
Mechanisms of antidepressant action and nutritional regulation of neuroendocrine functions (regulation of gene expression; molecular biology, neuroendocrinology and anatomy). |
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Billy Tsai
Dept CDB
761-4167
btsai@umich.edu
http://sitemaker.umich.edu/tsailab/members
Our laboratory is interested in understanding how certain toxins and viruses penetrate biological membranes to cause disease. |
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Michael Uhler
Dept MHRI/Biological Chemistry
647-3188
muhler@umich.edu
http://www2.ritc.med.umich.edu/?q=muhler
Regulation and specificity of serine-threonine protein kinases; regulation of calcium channels and neurotransmitter secretion. |
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Kristen Verhey
Dept Cell & Developmental Biology
615-7787
kjverhey@umich.edu
http://www.med.umich.edu/cdb/sub_pages/People/verhey.htm
The main focus of the lab is studying molecular motors that drive axonal transport. Current projects are focused on 1) how motors bind to their cargoes and get activated for transport and 2) how posttranslational modifications of the microtubules act as biochemical road signs to direct motor protein transport. |
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Nils Walter
Dept Chemistry
615-2060
nwalter@umich.edu
http://www.umich.edu/~rnapeopl
The Walter group studies the structural dynamics and function of ubiquitous non-coding RNAs, responsible for the regulation of gene expression, by single molecule and computational tools inside and outside of cells. Applications of this highly interdisciplinary work include the identification and optimization of ribozymes for gene therapy and as novel biosensors. |
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Cun-Yu Wang
Dept Bio & Mat Sci, Dental School
615-4386
cunywang@umich.edu
Oral infection and immunity. Adult stem Cells. Oncogenesis and signal transduction. |
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Stanley Watson
Dept MHRI/Psychiatry
763-3725
watsons@umich.edu
Stress circuits and molecular biology in brain, mental illnesses and their biological bases; microarray approaches; informatics; opioid and neuropeptide systems; neuronal circuits and their cellular elements. |
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Lois Weisman
Dept Cell & Developmental Biology
647-2539
lweisman@umich.edu
http://www.med.umich.edu/cdb/sub_pages/People/weisman.htm
Organelle trafficking in yeast. |
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Stephen Weiss
Dept Internal Medicine
764-0030
sjweiss@umich.edu
http://www.umich.edu/~mmgmed/faculty/bios/weiss.htm
Normal as well as neoplastic cell populations remodel the extracellular matrix by regulating the expression of complex gene programs that control cell motility, proteolytic activity, proliferation and morphogenesis. However, the identity of the upstream and downstream gene products that regulate these activities in normal or pathologic states remain unclear, especially within the context of the 3-dimensional matrix. Current efforts focus on identifying the regulation of transcription factors that control epithelial-mesenchymal transitions in carcinomatous states as well as the genetic programs that guide morphogenesis. |
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Deneen Wellik
Dept Internal Medicine / Cell and Developmental Biology
936-8902
dwellik@umich.edu
http://www.med.umich.edu/cdb/sub_pages/People/wellik.htm
My laboratory focuses on understanding the role of the Hox genes in mammalian development. Using mice mutant for these genes, we are exploring how Hox genes pattern the developing urogenital system and the axial skeleton. These studies combine mammalian genetics, molecular biology and basic biochemistry to understand how these genes function in development and disease.
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Michael Welsh
Dept Cell & Developmental Biology
763-2549
welsh@umich.edu
http://www.med.umich.edu/cdb/sub_pages/People/welsh.htm
The functions of small heat-shock proteins (sHSPs) are poorly understood. Ten sHSPs are expressed in humans and a variety of point mutations in several sHSPs have recently been demonstrated to cause a variety of muscle and motor neuron diseases. Our interests concern the role of sHSPs in these human diseases as well as the possibility that sHSPs may be involved in the pathologic mechanisms of Alzhemier's and Parkinson's disease. |
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Margaret Westfall
Dept Surgery
615-8911
wfall@umich.edu
http://sitemaker.umich.edu/westfall_lab/dr._westfall
My laboratory is interested in signaling-induced modifications of cardiac function under physiological conditions and in response to heart failure. |
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Max Wicha
Dept Internal Medicine
936-1831
mwicha@umich.edu
Effects of extracellular matrix components on cell growth and differentiation. Cancer stem cells. |
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John Williams
Dept Mol. Integ. Physiol
764-4376
jawillms@umich.edu
http://www.physiology.med.umich.edu/research/profiles/jawillms.htm
Intracellular signaling and the control of pancreatic function. |
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Thomas Wilson
Dept Pathology
764-2212
wilstonte@umich.edu
http://tewlab.path.med.umich.edu/
We study the molecular mechanisms of DNA double-strand break repair, especially nonhomologous end joining, and their relationship to mutagenesis associated with cancer and other processes. We use approaches in organisms from bacteria to man, with an emphasis on yeast genomic approaches. |
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Shawn Xu
Dept. Mol. Integ. Physiology
615-9311
shawnxu@umich.edu
http://lsi.umich.edu/facultyresearch/labs/xz-xu
Neuronal signaling, behavior and addiction in C. elegans. Calcium signaling. |
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Zhaohui Xu
Dept Biological Chemistry
615-2077
zhaohui@umich.edu
http://www.biochem.med.umich.edu/xulab/index.html
We study the molecular mechanisms regarding protein folding and protein trafficking within eukaryotic cells. |
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Pan Zheng
Dept Surgery, Pathology
615-3464
panz@umich.edu
http://www.med.umich.edu/immprog/faculty/Zheng.htm
Our laboratory is interested in tumor immunology and cancer biology. We study the mechanism in immune tolerance to tumor antigens in cancer models. We explores different ways to rescue the high avidity tumor antigen reactive T cells from negative selection and to modulate the function of regulatory T cells. We also study protein phosphatase as tumor suppressor in Wnt signaling. |
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Yuan Zhu
Dept Internal Medicine/Cell & Developmental Biology
647-3033
yuanzhu@umic.edu
http://www.umich.edu/~mmgmed/faculty/Zhu/zhu2.htm
lhttp://www.med.umich.edu/cdb/sub_pages/People/zhu.htm
Molecular and cellular mechanisms underlying growth regulation of normal and cancer stem cells in the nervous system. Mouse models for nervous system tumors. |
