The University of Michigan

Faculty Directory

Ben Allen
Cell and Developmental Biology
Research in the Allen Lab is broadly focused on understanding the mechanisms of growth factor and morphogen signaling in development and disease. Specifically, we study the regulation of Hedgehog (Hh) signaling in vertebrate embryogenesis using a wide range of approaches, including mouse developmental genetics, chick in ovoelectroporation, biochemistry, and cell biology.
Anthony Antonellis
Human Genetics, Neurology
Our objective is to obtain a better understanding of the development and function of neurons and glia in the peripheral nervous system using human genetics, molecular and cellular biology, and zebrafish transgenesis. The major end goal of these studies is to characterize how these cell types are affected in patients with peripheral neuropathies.
David Antonetti
Ophthalmology and Visual Sciences
Our laboratory is interested in understanding the cellular and molecular basis of the blood-brain and blood-retinal barrier and how these barriers are compromised in diseases such as diabetic retinopathy or brain tumors. The long-term goal of this research is to develop novel therapies to restore normal barrier function.
Peter Arvan
Internal Medicine
We are interested in diseases linked to defects in protein processing and trafficking in the intracellular secretory pathway. This also requires an intimate understanding of the workings of normal protein processing and trafficking pathways.
Sara Aton
Molecular, Cellular, and Developmental Biology
The effects of sensory experience and sleep on neural circuits, mechanisms underlying nervous system plasticity and memory formation.
Kate Barald
Cell and Developmental Biology, Biomedical Engineering, PIBS
Molecular and cellular studies of auditory system development and regeneration in the mouse (including transgenic approaches), chick, zebrafish and immortalized inner ear cell lines. Studies of hormonal regulation of the tumor suppressor gene, neurofibromatosis I, using embryonic mouse stem cell approaches. Microfluidic organ cultures of inner ears and zebrafish for studies of morphogenesis.
James Bardwell
Molecular and Cellular Developmental Biology
Protein folding, disulfide bond formation.
Sami Barmada
We are focused on the pathologic overlap between amyotrophic lateral sclerosis (ALS) and frontotemperal dementia (FTD), and how we can take advantage of the convergence to identify new and effective therapies. To do so, we investigate mechanisms of disease on the level of single cells using fully-automated longitudinal microscopy in mature neurons and astrocytes, derived from primary rodent cultures or human stem cells.
Scott Barolo
Cell and Developmental Biology
My lab studies the mechanisms by which transcriptional enhancers control gene expression during development, using genetic, biochemical, evolutionary, and bioinformatics approaches. We focus on enhancers that are directly regulated by cell signaling pathways, including Hedgehog, Wnt, Notch, and MAPK, all of which play important roles in development and disease.
Daniel Beard
Molecular & Integrative Physiology
Research in Dr. Beard's laboratory is focused on systems engineering approaches to understanding the operation of physiological systems in health and disease. Projects include theoretical and experimental analysis of metabolic systems, whole-body cardiovascular mechanics and transport, blood-flow regulation, mechanisms of renal solute transport.
Ernesto Bernal-Mizrachi
Division of Metabolism, Endocrinology, & Diabetes
The long-term goal of the research program in my laboratory is to delineate the signaling pathways responsible for regulation of beta-cell mass during normal condition or in states of adaptation to insulin resistance. The approach used in the laboratory includes the use of genetically modified animal models and in vitro experiments. More specifically, these experiments have focused on the importance of the insulin signaling pathway in regulation of β-cell mass, function and plasticity.
Stephanie Bielas
Human Genetics
Discovery of new genes for human developmental brain disorders highlights the genes essential for brain development. The disease mechanisms associated with these genes are modeled using patient induced pluripotent stem cells and mice to understand the associated molecular pathology.
Markus Bitzer
Internal Medicine
Our laboratory studies the role of small RNAs including microRNAs in modulating signaling cascades that mediate renal injury and aging.
Chad Brenner
Cell and Systems Biology, Genomics/Proteomics, Computational Biology, Cancer Biology
The overarching goal of the lab is to identify putative predictive genomic biomarkers for targeted therapies and understand primary and secondary resistance mechanisms for these therapies. The lab utilizes next generation sequencing strategies for the development and analysis of genomics-driven medicine clinical trials (precision medicine) and genetic characterization of therapeutic resistance. The lab also specializes in using high-throughput functional screens to identify therapeutic targets and molecular strategies to advance for pre-clinical modeling in cell lines and patient-derived xenograft models.
Ronald Buckanovich
Internal Medicine, Obstetrics and Gynecology
Our lab is interested in the study of the tumor vascular niche; this includes tumor vascular cells, tumor stem cells and mesenchymal stem cells. We are studying both the basic biology and developing therapeutics to disrupt the vascular niche and thereby inhibit the growth of tumor stem cells.
Charles Burant
Internal Medicine, Mol. Integ. Physiol.
Growth and differentiation of tissues in diabetes. Metabolomics in type 2 diabetes.
Margit Burmeister
Human Genetics, Psychiatry
We are interested in the identification and functional understanding of genes involved in behavior, neurological and psychiatric disorders.
Kenneth Cadigan
Molecular and Cellular Developmental Biology
We study Wnt signal transduction in Drosophila, focusing on the mechanism by which this conserved pathway regulates transcription. We also work on the control of apoptosis in rapidly growing tissues.
Sally Camper
Human Genetics
Birth defects research, organogenesis, mouse models of human disease growth insufficiency including hormonal and skeletal dysplasia, hearing and vestibular dysfunction.
Christine Canman
Human cells express multiple DNA polymerases that share the ability to utilize damaged DNA as a template for DNA replication, an activity that cannot be duplicated by our normal replicative high fidelity DNA polymerases. The fact that many anticancer drugs exert their main mechanism of action by targeting and damaging DNA brings forth the possibility that this biological pathway may be an important but unrecognized means by which cancer cells resist therapy. Our main objectives are to study the biological functions of these specialized DNA polymerases in intact cells as well as how they are tightly regulated during periods of replicative stress.
Thomas Carey
Otolaryngology/Head and Neck Surgery; Periodontics and Oral Medicine; Pharmacology
We study autoimmune hearing loss with emphasis on identification of antigenic targets of pathogenic antibodies. We also study genetic changes associated with cancer progression, signaling through galanin and its receptors, and identifying and overcoming mechanisms of resistance to chemotherapy in head and neck cancer.
Vernon Carruthers
Microbiology and Immunology
We study cellular and molecular aspects of pathogen-host interactions using the neurotropic protozoan parasite Toxoplasma gondii as a model pathogen. Humans acquire Toxoplasma infection (toxoplasmosis) through casual contact with infected cats or from oral ingestion of undercooked infected meat. Although most people harbor the lifelong infection without overt consequences, immune deficiency can trigger reactivation of a fulminant infection resulting in ocular disease, myocarditis, or encephalitis, which is often fatal. We use advanced genetic, cell biological, and biochemical approaches to identify the functions of parasite and host proteins contributing to parasite cell invasion, post-invasion survival, nutrient acquisition, replication, cell exit (egress), and motility. We also test novel preclinical therapies for toxoplasmosis and we have an interest in pursuing neurologic and behavioral aspects of infection. Our long-term goal is to understand the strategies Toxoplasma uses to successfully establish infection and manipulate its host to ensure survival and transmission. Knowledge gained from our studies is revealing mechanisms of cellular events at the pathogen-host interface that are relevant to parasite virulence and mammalian cell biology. We anticipate that our findings will also inform novel approaches to prevent or treat infections.
Christin Carter-Su
Mol. Integ. Physiol
Signal transduction pathways used by cytokine receptors and JAK tyrosine kinases; molecular actions of growth hormone; role of SH2-B adapter proteins in regulation of the cytoskeleton, gene expression and cellular differentiation and survival.
Marilia Cascalho
Microbiology and Immunology
The impact of Immune receptor diversity in the response to mutable pathogens and tumors; Immunological memory and transplantation; Mutable vaccines.
Raymond Chan
Human Genetics, Internal Medicine
Our lab studies how higher-order chromosome structures are established and maintained using the model organism Caenorhabditis elegans. In particular, we are focused on the function and regulation of the Structural Maintenance of Chromosome (SMC) protein family in organizing and packaging chromosomes and maintaining genomic stability.
Amy Chang
Molecular and Cellular Developmental Biology
We are working on protein sorting and quality control in the yeast secretory pathway.
Yuqing (Eugene) Chen
Internal Medicine
The Role of Nuclear Receptors in Obesity/Diabetes-Related Cardiovascular Complications.
Arul Chinnaiyan
Michigan Center for Translational Pathology
Dr. Chinnaiyan's laboratory has focused on functional genomic,proteomic and bioinformatics approaches to study cancer for the purposesof understanding cancer biology as well as to discover clinicalbiomarkers. He and his collaborators have characterized a number ofbiomarkers of prostate cancer including AMACR, EZH2 and hepsin. AMACRis being used clinically across the country in the assessment of cancerin prostate needle biopsies.
Uhn-Soo Cho
Biological Chemistry
My laboratory is interested in structural and biochemical studies of biologically important proteins and protein complexes, including histones/histone chaperones, kinetochore and centromere, mTOR regulating enzymes, and so on. X-ray protein crystallography is a major tool for structural studies of these proteins and electron microscopy and NMR are our secondary approaches depending on questions we like to address.
Kaushik Choudhuri
Microbiology and Immunology
We are broadly interested in the cell biology of T lymphocyte (T cell) function. These immune cells are central to cell-mediated immunity to infections and cancers. My laboratory uses high-resolution imaging approaches (including TIRFM, 3D super-resolution fluorescence microscopy, and transmission electron microscopy) to understand the molecular and subcellular mechanism by which T cells recognize and respond to pathogenic threats.
Tae-Hwa Chun
Internal Medicine
Our lab is interested in the proteolytic ECM remodeling of adipose tissues in development and obesity. Using 3-D adipocyte differentiation model and a series of genetically modified mice, we aim to define a molecular mechanism that links ECM remodeling to the regulation of organ function in development and diseases.
Kathleen Collins
Internal Medicine/Micro and Imm
Molecular Mechanisms of HIV Disease Pathogenesis.
William Dauer
The central goal of our studies is to unravel the molecular and cellular mechanisms of diseases that disrupt the motor system. Our primary focus is on Parkinson’s disease and DYT1 dystonia. For each of these projects, we focus our efforts on disease genes that cause these disorders, employing a range of molecular, cellular, and whole animal studies to dissect the normal role of disease proteins, and how pathogenic mutations lead to disease.
Mark Day
Proteolytic processing of tumor cells in prostate cancer metastasis. Regulation of novel E2F1 target genes following disruption of the Rb/E2F pathway in human cancer.
Sharlene Day
Cell and Systems Biology, Cell Physiology, Biochemistry, Genetics/Gene Regulation, Molecular Mechanisms of Disease
My laboratory studies disease mechanisms in cardiomyopathies with a major area of focus on regulation of the ubiquitin proteasome system in protein turnover and degradation. We are exploring the interaction between inflammation, proteasome dysfunction and ventricular remodeling in the heart. We are also interested in disease pathways triggered by sarcomere mutations in hypertrophic cardiomyopathy and understanding the interactions of the mutant allele product with RNA and protein surveillance systems.
Andrzej Dlugosz
Embryonic signaling pathways in development, regeneration, and neoplasia.
Gregory Dressler
My lab studies the molecular basis of embryonic development using the mammalian kidney as a model system. Transcription factors and cell signaling pathways are studied at the genetic and biochemical level to understand how extrinsic signals lead to intrinsic cell lineage specification, differentiation, and proliferation. How developmental regulatory pathways contribute to renal disease is also of interest.
Mara Duncan
Cell and systems biology; Biochemistry and structural biology; Genetics/gene regulation, Development, aging, neurobiology; Molecular mechanisms of disease, cancer biology
Cells encounter starvation during stroke and heart attack, during certain stages of development, and in rapidly growing tumors. Our lab studies how membrane traffic contributes to responses to starvation and normal cell physiology.
Monica Dus
Molecular, Cellular, and Developmental Biology
The goal of the lab is to understand the molecular and neural mechanisms behind behavior and to reflect on the role of the environment on the functioning of neural circuits. Our lab uses both molecular ("omics", genetics, etc.) and neurobiology techniques, such as behavior and in vivo brain imaging. Our goal is to uncover the molecular events underlying the establishment of behavioral states. A main focus of the lab is to study how neurons sense nutrients and how this impacts feeding behavior.
Daniel Eitzman
Internal Medicine
Our lab focuses on the genetic determinants of thrombosis, atherosclerosis, and inflammation.
James Elder
Dermatology/Radiation Oncology
Our laboratory is interested in molecular mechanisms controlling epidermal growth and differentiation, including how this process is linked to host defense and autoimmunity. For this purpose, we utilize cell biology, organ culture, transgenic animals, genetic linkage analysis, and gene expression profiling.
Douglas Engel
Cell and Developmental Biology
Our lab exploits mouse genetics to explore the molecular basis of human disease. We are examining the consequences of targeted loss of function (traditional and conditional knockouts) and gain of function (conventional and BAC transgenics) to understand the developmental regulation of several transcription factors we have cloned over the years (GATA-2, GATA-3, small Mafs and the TR2 and TR4 orphan nuclear receptors), and to unravel their distinct contributions organogenesis.
Xing Fan
Neurosurgery/Cell and Developmental Biology
Develop novel therapies for the malignant brain tumors based on depletion of cancer stem like cells.
Eric Fearon
Internal Medicine/Human Genetics
Cancer genetics, gastrointestinal cancer, oncogenes, tumor suppressor genes, beta-catenin, Wnt signaling, developmental biology, CDX2, E-cadherin.
Eva Feldman
The role of growth factors in the pathogenesis and treatment of neurologic disorders.
David Ferguson
DNA Repair and Genomic Stability in Mammals. We study how DNA repair prevents cancer, controls development of the immune system, and ensures proper overall mammalian development.
Diane Fingar
Cell and Developmental Biology
Regulation of signal transduction by the conserved protein kinase mTOR, the mammalian target of rapamycin.
Patrice Fort
Cell and systems biology; Genetics/gene regulation, genomics/proteomics, computational biology; Molecular mechanisms of disease, cancer biology
Our research focuses on studying retinal diseases and their mechanisms, in order to develop new treatments to prevent or reverse associated vision loss. A major focus in our lab is the development of strategies to treat retinal neurodegenerations, including diabetic retinopathy. One of our objectives is to investigate the function and regulation of crystallin proteins in the adaptive responses of retinal cells during chronic disease states such as diabetes.
Renny Franceschi
Dentristry/Perio-Prev and Geriatrics/Biological Chemistry
Signals regulating the formation and functioning of osteoblasts, the cells that produce and mineralize the extracellular matrix of bone; gene therapy approaches for regeneration of mineralized tissues.
Robert Fuller
Biological Chemistry
My laboratory studies protein localization and processing in the eukaryotic secretory pathway.
Philip Gage
Ophthalmology and Visual Sciences
The goal of our laboratory is to understand the molecular mechanisms underlying normal and abnormal mammalian eye development. The approaches we employ include mouse models, functional genomics, and cell culture systems.
Roman Giger
Cell and Developmental Biology
A long standing goal of our research is to understand how neuronal growth and sprouting is regulated in the mammalian nervous system during development, adult neuronal plasticity, and following injury (i.e. spinal cord injury, traumatic brain injury, stroke or multiple sclerosis). We pursue a mouse genetic approach to study the function of different classes of proteins that are known to regulate neuronal growth, including members of the Semaphorin family and their cognate receptors (Neuropilins and Plexins), myelin-associated inhibitors and their receptors. The Nogo Receptors NgR1 and NgR2 have been implicated in regulating acute neuronal responses to the myelin inhibitors Nogo/RTN4, Myelin-Associated Glycoprotein (MAG), and Oligodendrocyte-Myelin Glycoprotein (OMgp). We recently identified a novel function for NgR1 in regulating activity-dependent synaptic strength. Ongoing studies are aimed at understanding the mechanisms of how enhanced neuronal plasticity leads to improved functional outcomes following nervous system injury.
David Ginsburg
HHMI/Internal Medicine/Human Genetics
David Ginsburg is interested in understanding the components of the blood-clotting system and how disturbances in their function lead to human bleeding and blood-clotting disorders.
Thomas Glover
Human Genetics/Pediatrics
Molecular cytogenetics and the molecular biology of human disease.
Daniel Goldman
Biological Chemistry
We investigate the cellular and molecular mechanisms underlying retina regeneration in zebrafish and neuromuscular synapse regeneration in mice. We anticipate this research will suggest novel strategies for stimulating retinal repair in people suffering from blinding eye diseases and enhance motor function in people suffering from motor neuron disease and age-related sarcopenia.
Aaron Goldstrohm
Biological Chemistry
We study the regulation of messenger RNAs in eukaryotes, focusing on the control of mRNA stability, translation, and localization by RNA binding proteins and ribonucleases. Biochemical, genetic, and cell-based approaches are combined using yeast, Drosophila, and human cells. High throughput screens are being developed to identify regulatory mechanisms and chemical inhibitors that can modulate gene expression.
Deborah Gumucio
Cell and Developmental Biology
We study the role of Hedgehog signaling during development. In the developing intestine, hedgehog is secreted from the epithelium and acts on at least six different cell types in the underlying stroma. Hedgehog plays multiple roles, including formation and patterning of the villi, development of the smooth muscle layers and, in the adult, control of inflammatory signaling. We investigate these aspects using genetic mouse models, bioinformatics, in vitro organ systems, and live cell confocal microscopy. Our studies are relevant to several important human diseases of the gastrointestinal system, including idiopathic hypertrophic pyloric stenosis, short bowel syndrome, irritable bowel syndrome and inflammatory bowel disease (Crohn's and Celiac disease as well as ulcerative colitis).
Gary Hammer
Internal Medicine/Mol. Integ. Physiol
Dr. Gary D. Hammer, M.D., Ph.D. is a medical endocrinologist specializing in the treatment of adrenal and gonadal diseases. Work in his laboratory has focused on the mechanisms by which signaling and transcriptional programs initiate adrenal-specific growth and differentiation with an emphasis on the dysregulated growth of adrenocortical stem cells in development and cancer.
Michael Holinstat
My lab focuses on understanding how platelets regulate flow in the vessels and identifying new targets for the development of novel anti-platelet therapeutics to minimize the occurrence of vessel occlusion which leads to myocardial infarction. Using animal and human models, the lab investigates the regulation of platelets from an in vitro, ex vivo and in vivo perspective including state-of-the-art intravital live imaging of platelet activation and vessel occlusion in animal models and ex vivo investigations of platelet function from human models.
Joseph Holoshitz
Internal Medicine
The role of signal transduction events in health and disease.
Ronald Holz
Mechanisms of neurotransmitter and hormone secretion; membrane permeability.
Patrick Hu
Int Med/CDB
The Hu lab uses the nematode C. elegans as a model system for studying evolutionarily conserved signal transduction pathways that are dysregulated in cancer and diabetes, with the eventual goal of generating hypotheses that can be tested in mouse models of human disease.
Michael Imperiale
Microbiology and Immunology
Our lab studies the molecular biology of small DNA tumor viruses, including how they interact with the host immune reponse, how they assemble, and how the cause ongogenic transformation. We are also interested in their use as gene therapy vectors.
Ken Inoki
Molecular and Integrative Physiology and the Internal Medicine
Our lab is investigating the role of mTOR signaling pathway in metabolic diseases such as diabetes and cancer development.
Lori Isom
The goal of our research is to test the hypothesis that beta subunits of voltage-gated Na+ channels (VGSCs) are cell adhesion molecules (CAMs) that communicate between extra- and intra-cellular signaling and cytoskeletal proteins.
Ursula Jakob
Molecular Cellular and Development Biology
Oxidative stress and redox regulation.
Paul Jenkins
Our laboratory is interested in the mechanisms by which mutations in ankyrin-G (product of the bipolar disorder and schizophrenia risk factor gene, ANK3 ) contribute to complex neuropsychiatric diseases, as well as the general mechanisms of plasma membrane organization in polarized cells.
Ajit Joglekar
Cell & Developmental Biology
Mechanochemistry of genome inheritance.
Vesa Kaartinen
Biologic and Materials Sciences
We study molecular mechanisms that regulate craniofacial and cardiac development.
Alon Kahana
Molecular mechanisms of disease, cancer biology, Development, aging, neurobiology
In the Kahana Lab we focus on the roles of neural crest-derived and muscle-derived progenitor stem cells in disease and tissue regeneration, and are primarily interested in the intersecting biological processes that underlie embryogenesis, oncogenesis and adult tissue regeneration.
Sundeep Kalantry
Human Genetics
Our research aims to define the epigenetic mechanisms that regulate X-chromosome inactivation, which results in transcriptional silencing of most genes along one of the two X-chromosomes in female mammals.
Catherine Keegan
Dept. Pediatrics-Genetics
We are interested in the role of telomeric proteins in maintaining genomic stability during development. We are currently studying the adrenocortical dysplasia(acd) mutant mouse as a model for birth defects that are caused by telomere dysfunction. We also have an interest in mouse models of human congenital malformations of the urogenital system and caudal region.
Evan Keller
Our laboratory studies the biology of prostate cancer skeletal metastases through a variety of methods. Our current work focuses on examining bone morphogenetic proteins (BMPs) that work through SMAD transcription factors, exploring a signal transduction factor that diminishes prostate cancer metastases, and investigating how interleukin-6 stimulates the androgen receptor in prostate cancer cells.
John Kim
Human Genetics
We study the function of microRNAs and RNAi mechanisms in C. elegans and cell culture systems. We investigate how microRNA-associated complexes regulate target gene expression using muscle development and embryogenesis as model experimental systems. We also study how different classes of small noncoding RNAs control germline development in C. elegans.
Celina Kleer
The Kleer laboratory studies the mechanism by which overepression of EZH2 and down-regulation of CCN6 (WISP3) promote breast cancer invasion and metastasis, and their utility as novel tissue biomarkers of prognosis.
Ronald Koenig
Internal Medicine
Research is focused in the following areas: 1) the role of a Pax8-PPARgamma fusion protein (caused by a chromosomal translocation) in the development of thyroid cancer; 2) the function of thyroid hormone receptor alpha-2, an alternative splice product of the thyroid hormone receptor alpha transcript that does not bind thyroid hormone but that binds RNA; 3) the role of selenoproteins in protecting against oxidative stress in diabetes; and 4) the roles of retinoic acid and BMP4 in inner ear development and function.
Anuj Kumar
Molecular, Cellular, and Developmental Biology
We use genomics and proteomics to study signaling networks regulating yeast cell growth, cell polarity and cell cycle progression. These networks serve as orthologous models of pathways relevant for: 1) fungal infections of immunocompromised individuals; 2) tumor cell metastasis; 3) cancer research.
Steven Kunkel
Experimental research activities directed at understanding the cellular and molecular mechanisms of cytokine networks that are operative in different immune/inflammatory reactions and host defenses represent the major research efforts in the laboratory.
John Kuwada
Molecular Cellular and Developmental Biology
We are interested in identifying and understanding genes that regulate the formation and function of neural circuits in the vertebrate CNS.
Daniel Lawrence
Internal Medicine
Understanding how fundamental binary protein; protein interactions regulate complex physiologic processes.
Cheng-Yu Lee
Cell and Developmental Biology
Jun Li
Human Genetics
My group studies the genetic basis of complex human diseases. Current areas include genetic and genomic analyses of mental disorders, somatic DNA alterations in cancer, and human population genetics.
Qing Li
Internal Medicine - Hematology/Oncology
Intrinsic and extrinsic mechanisms underlying leukemic stem cell transformation.
Andrew Lieberman
Study of the mechanisms of neurodegeneration in CAG/polyglutamine disorders and Niemann- Pick C using mouse and cellular models. Our goal is understand disease pathogenesis and define novel targets for treatment.
Jiandie Lin
Our laboratory is investigating the regulatory networks that control nutrient and energy metabolism, using integrated genomic, metabolomic, molecular, and mouse genetic tools. We are interested in exploring the pathogenic mechanisms underlying type 2 diabetes, cardiovascular disease, and non-alcoholic fatty liver disease, and their potential for therapeutic development.
Xiaoxia "Nina" Lin
Cell and Systems Biology, Cell Physiology, Biochemistry; Microbial Pathogenesis, Immunology
My research focuses on investigating microorganisms, particularly microbial communities, using systems/synthetic biology approaches. We aim to engineer synthetic microbial consortia for efficient, robust and sustainable biofuel/chemical production; in synergy, we aim to elucidate important natural microbial communities (e.g. human microbiome) by exploiting microfluidics and network modeling tools.
Allen Liu
Cell and systems biology, biochemistry and structural biology
Mechanical and biochemical regulation of clathrin-mediated endocytosis, GPCR dimerization, artificial platelets.
Yang Liu
My laboratory studies the overlapping area of immunology, cancer biology and autoimmune diseases. We are interested in genetic control of cancer and autoimmune diseases, cell surface interactions critical for T cell activation and autoimmunity, and interaction between cancer cells and immune and hematopoietic system.
Mats Ljungman
Radiation Oncology
Mechanisms of activation of DNA damage signaling, Molecular targets for sensitization of cancer cells to radiation and chemotherapy.
Malcom Low
Molecular and Integrative Physiology
Research in my lab is focused on determining how neurons in the hypothalamus integrate hormonal information and signals from other brain areas to maintain normal body weight, energy balance, and glucose homeostasis. We use molecular biological techniques, including mutant mouse models, to characterize neuron-specific transcriptional enhancers in the proopiomelanocortin gene; neuroanatomic methods to study hypothalamic circuits; and behavioral assays combined with neuropharmacology to study meal microstructure and motivational/reward aspects of feeding.
Carey Lumeng
Pediatrics Pulmonary Division
Work in Lumeng Laboratory focuses on understanding the links between obesity and inflammation and how this impacts human health. We are focused on examining how adipose tissue contributes to inflammation in obesity by understanding the biology of the inflammatory cells that reside in fat. We are particularly interested in the role that adipose tissue macrophages (ATMs), adipose tissue T cells, and other leukocytes play in the biology of adipose tissue.
Ormond MacDougald
Molecular and Integrative Physiology
The goals of our research program are to determine the molecular mechanisms by which extracellular signals regulate mesenchymal cell fate decisions, and to improve our understanding of adipocyte metabolism. Mesenchymal stem cells have the capacity to differentiate into a number of cell types, including adipocytes, osteoblasts and myocytes.
Ivan Maillard
Int Med-Hematology/Oncology
The Maillard lab investigates the interaction of blood-forming stem cells with their environment, using the mouse as a model organism. Another interest of the laboratory is in the regulation of peripheral T cell homeostasis and function by Notch signaling.
Benjamin Margolis
Biological Chemistry/Internal Medicine
Our laboratory studies the role of protein complexes in epithelial cell polarization and ciliogenesis.
David Markovitz
Internal Medicine
Interaction between retroviruses and human cellular proteins. Mechanism of action of the DEK oncoprotein. Role of vimentin in immunity and cancer. Kaposi’s Sarcoma.
Donna Martin
Human Genetics
Molecular genetics of transcription factor mediated neuronal development; gene targeting; studies of human and mouse developmental disorders.
Miriam Meisler
Human Genetics
We are studying the molecular basis of neurological disorders using mouse models of epilepsy, movement and behavioral disorders. This work has enabled us to identify several human disease mutations.
Ram Menon
Research efforts are focused on the development of diabetic kidney disease and understanding the mechanisms underlying the role of growth hormone in the causation of certain chronic complications of type 1 diabetes mellitus.
Sofia Merajver
Internal Medicine
Molecular genetics of aggressive breast cancer phenotypes and hereditary breast cancer. Angiogenesis, molecular therapeutics.
Juanita Merchant
Internal Medicine/Mol. Integ. Physiol
Dr. Merchant's primary research interests include transcriptional control mechanisms regulating cell growth and differentiation and microbial-host interactions in the upper GI tract. Applications of her work involve the role of inflammation in the stomach, the development of peptic ulcers and gastrointestinal cancer.
Edgar Meyhofer
Mechanical Engineering
Kinesin, biomolecular motors, molecular sorting.
Dan Michele
Molecular and Integrative Physiology
Molecular mechanisms of muscular dystrophy and inherited cardiomyopathies.
Ann Miller
Molecular, Cellular and Developmental Biology
Our lab studies the molecular mechanisms by which the Rho small GTPase regulates cytokinesis normally and how the Rho signaling pathway and cytokinesis may become misregulated in cancers. Our work is carried out at the cell biological level in the intact vertebrate epithelium using Xenopus laevis (African clawed frog) embryos as a model organism.
David Miller
Internal Medicine
Cellular and molecular mechanisms of viral RNA replication and the innate immune response to viral infections.
Richard Miller
Rich Miller's laboratory studies the control of aging in mice, with current emphasis on genetic control of the rate of aging and the relationship between cellular stress resistance and disease resistance in long-lived mice.
Suzanne Moenter
Molecular and Integrative Physiology
Study synaptic and intrinsic properties of gonadotropin-releasing hormone neurons to understand how the brain controls fertility in normal homeostasis and how this changes in various pathophysiologies of infertility.
Beth Moore
Molecular Mechanisms of disease and aging
The Moore laboratory works in two main areas. The first is in the pathogenesis of fibrotic lung disease where we study epithelial cell, fibroblast and inflammatory cell interactions and their regulation by eicosanoids, chemokines and matricellular proteins. In our other main research area, we study the reconstitution of innate and adaptive immunity post-stem cell transplant using models of both bacterial and viral pathogens.
John Moran
Human Genetics
We are interested in how transposable elements have impacted the human genome.
Richard Mortensen
Internal Medicine/Mol. Integ. Physiol
Molecular Mechanisms of Insulin Resistance, inflammation, metabolic disorders and associated cardiovascular disease.
Jacob Mueller
Human Genetics
We study the biology of the X chromosome, with particular focus on its complex genomic architecture and enrichment of genes involved in germ cell development.
Martin Myers
Internal Medicine, Molecular and Integrative Physiology
Dr. Myers' research focuses on the processes that enable the body to respond normally to insulin, and how problems in these pathways contribute to the development of insulin resistance and diabetes. His laboratory specifically concentrates on the crucial role played by nerve centers in the unconscious part of the brain - what Myers calls "glycemic control centers"- that regulate the body's ability to respond to insulin.
Jayakrishnan Nandakumar
Telomerase, telomeres, cancer, ageing
We use biochemical, cell biological and X-ray crystallographic tools to understand the functions of telomeres and telomerase, complexes that are intricately involved with cancer, stem cell biology, and aging.
Gabriel Nunez
Role of Innate Immunity in Host Defense and Cancer
Akira Ono
Microbiology and Immunology
Our lab studies the relationships between cellular structures and enveloped viruses. We are particularly interested in the roles played by cellular membranes during the life cycle of HIV-1.
Marina Pasca Di Magliano
Cell and Developmental Biology
Our laboratory investigates the formation and progression of pancreatic cancer, one of the most lethal human malignancies. We study embryonic signaling pathways, such as Hedgehog and Wnt, which are activated during pancreatic carcinogenesis. The Hedgehog signaling pathway is not active in healthy adult pancreas. However, in pre-malignant lesions and in invasive pancreatic cancer Hedgehog signaling becomes activated via overexpression of one of the ligands, Sonic Hedgehog (Shh).
Henry Paulson
Polyglutamine neurodegenerative disease; Spinocerebellar Ataxia type 3; RNA interference as potential therapy including studies of polyglutamine diseases and Alzheimer's disease; Protein quality control in normal brain function in disease.
Brian Pierchala
Department of Biologic and Materials Sciences
Neuronal growth factors regulate many aspects of nervous system development including survival, differentiation, axon guidance and circuit formation. These same factors are also critical for maintenance and plasticity of the adult nervous system. The Pierchala laboratory investigates the mechanisms of action of these growth factors, focusing attention on the Glial Cell Line-Derived Neurotrophic Factor (GDNF) family and the neurotrophins. The potent survival and trophic activities ofneuronal growth factors, particularly the GDNF family, have led to their development as therapeutic agents for the treatment of diseases and injuries of the nervous system. Therefore, an understanding of receptors complexes and signal transduction pathways regulated by neurotrophic factors under physiologic conditions will aid in the design of treatment regimens that utilize these factors.
Scott Pletcher
Molecular and Integrative Physiology
Our goal is to identify and investigate genetic mechanisms that are likely to be important for aging and age-related disease in humans by focusing on equivalent, conserved processes in the fruit fly, Drosophila melanogaster. Currently we are studying neuronally-expressed genes involved in linking diet, obesity, and immune function with aging and aging-related disease.
Malini Raghavan
Microbiology and Immunology
CD8+ T cells are important for immune responses. Our laboratory studies mechanisms of assembly of major histocompatibility complex (MHC) class I molecules, which are the ligands for T cell receptors of CD8+ T cells. Our studies encompass mechanisms of function of specific assembly factors and generic endoplasmic reticulum chaperones relevant to MHC class I assembly, and the impacts of MHC class I polymorphisms on assembly characteristics and infectious disease outcomes.
Stephen Ragsdale
Biological Chemistry
We study how organisms use gases (CO, CO2, CH4) in metabolism and in metabolic regulation, how metals catalyze reactions and how thiol/disulfide redox switches regulate the activity of enzymes, ion channels and transcriptional regulators. We target systems that are important in human health, environmental biology, and biological energy conversion.
Alnawaz Rehemtulla
Radiation Oncology
Non-invasive detection of molecular events in live animals (Molecular Imaging).
Diane Robins
Human Genetics
We study hormone-regulated gene expression, from basic mechanisms of androgen receptor action to steroid-dependent cancer (prostate and breast), in mouse models and in vitro. Additionally, we study transcriptional repression in sexually dimorphic liver gene expression, focusing on genome evolution and reproductive biology.
Liangyou Rui
Mol. and Integ. Physiol
Cell signaling and molecular mechanism of obesity and type 2 diabetes.
Mark Russell
Department of Pediatrics and Communicable Diseases
Dr. Russell is studying mechanisms of cardiac and skeletal myofibril assembly, alignment and structural support, topics central to the pathophysiology of, and development of new therapies for, heart failure, myopathy and muscular dystrophy. His laboratory is currently using cell culture as well as mouse and zebrafish model systems to determine the functions of a novel pair of genes, obscurin and obscurin-like 1, that have been cloned and characterized in his laboratory.
Alan Saltiel
Internal Medicine/Mol. Integ. Physiol
New Pathways in Disorders of Glucose and Lipid Metabolism.
Linda Samuelson
Mol. Integ. Physiol
Research in the Samuelson lab is focused on the development and physiology of gastrointestinal tissues. Specific topics include mechanisms regulating gastric acid secretion, cellular differentiation of cells in the stomach and intestine, function of the gastrointestinal hormones gastrin and CCK, gut endocrine cell development, and parietal cell biology.
John Schiefelbein
Molecular Cellular and Developmental Biology
Our lab is interested in the molecular mechanisms that regulate cell fate. We use molecular, genetic, cellular, and bioinformatics approaches to address basic questions concerning the specification of distinct cell identities during the development of multicellular organisms.
Santiago Schnell
Molecular & Integrative Physiology
The Schnell lab investigates multiscale cellular physiology mechanisms. We develop models for the analysis of biochemical reactions and biophysical processes. We used these models to investigate a variety of cell physiology problems. We are particularly interested in investigating the molecular mechanisms of pancreatic b-cells turnover and dysfunction in diabetes, the dynamics of metabolic pathways in cancer cells and the mechanisms of protein misfolding and aggregation in conformational diseases.
Audrey Seasholtz
Biological Chemistry
Molecular mediators of stress and anxiety; regulation and role of CRH, the CRH receptors and CRH-binding protein in stress; mechanisms of transcriptional regulation; transgenic mice.
JoAnn Sekiguchi
Internal Medicine
Our lab studies mechanisms of DNA repair and how aberrant repair processes affect genomic stability, predisposition to cancer and immune system development.
Yatrik Shah
Molec & Integrative Physiology
The major goal of our research program is to determine the molecular mechanisms by which oxygen sensing transcription factors regulate gastrointestinal homeostasis, inflammation and cancer. Cellular oxygen level is an important systemic signal that modulates metabolic activities and disease in the liver and intestine. Low cellular oxygen also referred to as hypoxia is observed in several gastrointestinal diseases such as non-alcoholic and alcoholic fatty liver disease, inflammatory bowel disease and liver and colon cancers.
Jordan Shavit
The Shavit laboratory studies the genetics of human blood clotting disorders using zebrafish and mouse models. We are developing large scale zebrafish mutagenesis screens to identify genetic and chemical modifiers of these disorders. This will be followed by investigation of these modifiers in mouse models and human populations.
Kanakadurga Singer
Research in the Singer lab is focused on understanding the influence of diet-induced obesity on hematopoiesis and the generation of activated macrophages that lead to metabolic disease.Current projects in the laboratory focus on (1) sexually dimorphic inflammatory responses responses to high fat diet and (2) mechanisms driving hematopoietic stem cell myeloid differentiation after high fat diet exposure. This work in mouse models uses bone marrow transplantation, stem-cell analysis techniques, and metabolic profiling.
Sivaraj Sivaramakrishnan
Cell and Developmental Biology
Cooperative behavior of molecular motors, protein engineering of FRET bio-sensors, signaling pathways in cardiac hypertrophy
Georgios Skiniotis
Life Sciences Institute, Biological Chemisry
The Skiniotis lab is interested in the 3D visualization of dynamic macromolecular assemblies and the delineation of mechanistic aspects of their operation primarily based on the application of electron cryo-microscopy (cryo-EM). The lab is current investigating the structural biology of cytokine receptors and G protein coupled receptor (GPCR) complexes and the structure and dynamics of Type I polyketide synthases (PKSs), in order to delineate the principles of natural product formation and set the stage for bioengineering synthases that create novel complex molecules with improved pharmacological properties.
Terry J. Smith
Ophthalmology and Visual Sciences
My laboratory group studies the molecular and cellular mechanisms involved in autoimmunity such as occurs in Graves' disease. We employ both in-vitro and small rodent experimental models to assess the signaling pathways, transcriptional and post-transcriptional events involved in the pathogenesis of thyroid-asociated ophthalmopathy, a component of Graves' disease. Our ultimate goal is the identification of drug targets that will improve the treatment of this vexing disorder.
Jason Spence
Department of Internal Medicine
Our lab uses insights gained from studying development of model organisms, and applies these insights to human pluripotent stem cells (hPSCs) in an attempt to generate novel in vitro models to study human development and disease.
Katherine Spindler
Microbiology and Immunology
Molecular biology and pathogenesis of virus-host interactions; genetic basis of host susceptibility to infection; mouse adenovirus type 1 encephalitis.
Roger Sunahara
My laboratory is interested in the delineation of the mechansim of activation of the G protein coupled receptor signaling pathway. We use biochemical and biophysical approaches to study both the structure and function initiating at the hormone-receptor binding event.
Andrew Tai
Cell and Systems Biology, Cell Physiology, Biochemistry, Microbial pathogenesis
We study the host factors and pathways that are exploited by RNA viruses, such as hepatitis C virus and dengue virus, for their life cycles.
Alice Telesnitsky
Microbiology and Immunology
Retroviral genetic variation and intracellular RNA trafficking.
Robert Thompson
Mechanisms of antidepressant action and nutritional regulation of neuroendocrine functions (regulation of gene expression; molecular biology, neuroendocrinology and anatomy).
Peter Todd
Molecular mechanisms of disease
Our group is interested in how RNA biology impacts neuronal function and neurological disease. To this end, we study a set of human disorders that result from nucleotide repeat expansions. In these disorders, which include Fragile X-associated disorders, myotonic dystrophy, ALS, and Frontotemporal Dementia, the repeated sequences as RNA trigger neurodegeneration and neuronal dysfunction. We study these disorders using a variety of tools and models, including molecular and biochemical approaches, next generation sequencing techniques, human cellular models, and drosophila and mammalian systems while taking advantage of the culture of collaboration at Michigan.
Ray Trievel
Biological Chemistry
Our laboratory is interested in elucidating the molecular mechanisms underlying chromatin modifications that regulate gene expression and other chromatin-associated functions.
Billy Tsai
The Tsai laboratory is interested in clarifying the cellular entry pathways of a bacterial toxin (cholera toxin) and a DNA tumor virus (polyomavirus). Specifically, we wish to identify the host factors hijacked by these toxic agents during the course of infection, and to illuminate the molecular nature of the host-pathogen interactions.
Kristen Verhey
Cell and Developmental Biology
The main focus of the lab is studying molecular motors that drive axonal transport. Current projects are focused on 1) how motors bind to their cargoes and get activated for transport and 2) how posttranslational modifications of the microtubules act as biochemical road signs to direct motor protein transport.
Nils Walter
The Walter group studies the structural dynamics and function of ubiquitous non-coding RNAs, responsible for the regulation of gene expression, by single molecule and computational tools inside and outside of cells. Applications of this highly interdisciplinary work include the identification and optimization of ribozymes for gene therapy and as novel biosensors.
Yanzhuang Wang
Molecular, Cellular and Developmental Biology
Golgi Biogenesis, Function, and Defects in Diseases
Zhong Wang
Cardiac Surgery
The research focus in the Wang laboratory is to dissect how epigenetic events determine stem cell self-renewal and differentiation.
Stanley Watson
Stress circuits and molecular biology in brain, mental illnesses and their biological bases; microarray approaches; informatics; opioid and neuropeptide systems; neuronal circuits and their cellular elements.
Lois Weisman
Cell and Developmental Biology
Organelle trafficking in yeast.
Stephen Weiss
Internal Medicine
Normal as well as neoplastic cell populations remodel the extracellular matrix by regulating the expression of complex gene programs that control cell motility, proteolytic activity, proliferation and morphogenesis. However, the identity of the upstream and downstream gene products that regulate these activities in normal or pathologic states remain unclear, especially within the context of the 3-dimensional matrix. Current efforts focus on identifying the regulation of transcription factors that control epithelial-mesenchymal transitions in carcinomatous states as well as the genetic programs that guide morphogenesis.
Deneen Wellik
Internal Medicine / Cell and Developmental Biology
My laboratory focuses on understanding the role of theHoxgenes in mammalian development. Using mice mutant for these genes, we are exploring howHoxgenes pattern the developing urogenital system and the axial skeleton. These studies combine mammalian genetics, molecular biology and basic biochemistry to understand how these genes function in development and disease.
Margaret Westfall
My laboratory is interested in signaling-induced modifications of cardiac function under physiological conditions and in response to heart failure.
Eric White
Internal Medicine
My laboratory focuses on the role of extracellular matrix signaling, with an emphasis on fibronectins, in lung tissue repair and homeostasis. A second line of investigation deals with the role of the tumor suppressor PTEN (phosphatase and tensin homologue on chromosome ten) in mediating lung fibroblast phenotype.
Max Wicha
Internal Medicine
Effects of extracellular matrix components on cell growth and differentiation. Cancer stem cells.
Thomas Wilson
We study the molecular mechanisms of DNA double-strand break repair, especially nonhomologous end joining, and their relationship to mutagenesis associated with cancer and other processes. We use approaches in organisms from bacteria to man, with an emphasis on yeast genomic approaches.
Christiane Wobus
Microbiology and Immunology
My laboratory is interested in the mechanisms of norovirus - host interactions in vitro and in vivo. Our main focus is on the early events in the viral life cycle. Our research currently focuses on two main areas: 1) determining the mechanism of MNV entry into permissive murine macrophages and dendritic cells as well as transcytosis across intestinal epithelial monolayers in vitro, 2) identifying the MNV receptor(s) and defining their receptor binding site on the MNV capsid.
Sunny Wong
Department of Dermatology
Hair follicle morphogenesis, wound healing and skin cancer.
Jun Wu
Department of Molecular & Integrative Physiology
Our work focuses on a recently identified form of fat cells, called beige cells. In mice, genetic manipulations creating more of these fat cells bring about strong anti-obesity and anti-diabetic effects. Further understanding of beige fat biology, including molecular regulation of beige fat function, therapeutic potential of human beige fat, and the developmental origin of beige precursors, will present novel therapeutic avenues and identify potential targets for intervention.
Shawn Xu
Dept. Mol. Integ. Physiology
Neuronal signaling, behavior and addiction in C. elegans. Calcium signaling.
Zhaohui Xu
Biological Chemistry
We study the molecular mechanisms regarding protein folding and protein trafficking within eukaryotic cells.
Yukiko Yamashita
Center for Stem Cell Biology
Yamashita is investigating mechanisms how adult stem cells (or tissue-specific stem cells) maintain tissue homeostasis, using the Drosophila male germ line as a model system.
Bing Ye
Cellular & Developmental Biology
To suit their sophisticated function, neurons are highly compartmentalized. Our goal is to define how neuronal compartmentalization contributes to the assembly and function of neural circuits, and how defects in this process lead to human diseases. We employ a multitude of approaches, including advanced in vivo imaging techniques, Drosophila genetics, and mammalian neuronal cultures, to this problem
Lei Yin
Molecular and Integrative Physiology
Protein degradation in circadian rhythm regulation. Metabolic function of circadian rhythms.
Xiaochun Yu
Internal Medicine
We study mechanisms of DNA damage response and chromatin remodeling related to tumor suppression.
David Zacks
Cell and systems biology, Biochemistry and structural biology, Molecular mechanisms of disease
Dr. Zacks is a vitreo-retinal specialist and clinician-scientist at the University of Michigan, Kellogg Eye Center. He has an NIH-funded research effort focusing on the molecular regulatory mechanisms controlling photoreceptor death or survival during periods of retinal disease. He is a member of the University of Michigan Vision Training Program and the Program in Cellular and Molecular Biology. He is also Co-Director of the Center for Gene and Molecular Therapy at the Kellogg Eye Center.