Headshot of Cheng-Yu Lee

Education

Ph.D from the University of Ma University of Maryland; B.S. University of Maryland;  

Research Focus

  • Understanding the molecular mechanisms by which newly identified fly genes regulate self-renewal vs. differentiation in fly neuroblasts.



    • Publications

    Representative Publications

    • Lee, C. Y., Wilkinson, B. D., Siegrist, S. E., Wharton, R. P., & Doe, C. Q. (2006). Brat is a Miranda cargo protein that promotes neuronal differentiation and inhibits neuroblast self-renewal. Developmental Cell, 10, 441-449. PubMed Link
    • Lee, C. Y., Robinson, K. J., & Doe, C. Q. (2006). lgl, pins and aPKC regulate neuroblast self-renewal versus differentiation. Nature, 439, 594-598. PubMed Link
    • Lee, C. Y., Clough, E. A., Yellon, P., Teslovich, T. M., Stephan, D. A., & Baehrecke, E. H. (2003). Genome-wide analyses of steroid- and radiation- triggered programmed cell death in Drosophila. Current Biology, 13, 350-357. PubMed Link
    • Rolls, M. M., Albertson, R., Shih, H. P., Lee, C. Y., & Doe, C. Q. (2003). Drosophila aPKC regulates cell polarity and cell proliferation in neuroblasts and epithelia. Journal of Cell Biology, 163, 1089-1098. PubMed Link
    • Lee, C. Y., Cooksey, B. A. K., & Baehrecke, E. H. (2002). Steroid regulation of midgut cell death during Drosophila development. Developmental Biology, 250, 101-111. PubMed Link
    • Lee, C. Y., Simon, C. R., Woodard, C. T., & Baehrecke, E. H. (2002). Genetic mechanism for the stage- and tissue-specific regulation of steroid triggered programmed cell death in Drosophila. Developmental Biology, 252, 138-148. PubMed Link
    • Lee, C. Y., & Baehrecke, E. H. (2001). Steroid regulation of autophagic programmed cell death during development. Development, 128, 1443-1455. PubMed Link
    • Lee, C. Y., Wendel, D. P., Reid, P., Lam, G., Thummel, C. S., & Baehrecke, E. H. (2000). E93 directs steroid-triggered programmed cell death in Drosophila. Molecular Cell, 6, 433-443. PubMed Link
    • Lee CY, Andersen RO, Cabernard C, Manning L, Tran KD, Lanskey MJ, Bashirullah A, Doe CQ. (2006) Drosophila Aurora-A kinase inhibits neuroblast self-renewal by regulating aPKC/Numb cortical polarity and spindle orientation. Genes Dev. 2006 Dec 15;20:3464-74