Faculty

    Headshot of Kate Barald

    Barald, Kate 
  • Professor
  • Office: 734 647 3376  3053 BSRB
    Barald Lab: 734 764 1528   3698 BSRB
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  • Developmental neurobiology, molecular neurobiology studies of developing neuronal cell and synapses of the inner ear; neuronal regeneration in the inner ear; studies of Neurofibromatosis 1; stem cell studies of neuronal, Schwann cell and heart development
    Headshot of James Douglas Engel

    Engel, James Douglas 
  • Professor and Chair
  • Office: 734 615 7509  3071 BSRB
    Engel Lab: 734 615 7248   3608 BSRB
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  • Mouse Developmental Genetics and Transcription; uses molecular genetics to understand the mechanisms underlying developmental determination during mammalian embryogenesis.
    Headshot of Roman Giger

    Giger, Roman 
  • Associate Professor
  • Office: 734 647 2090  3065 BSRB
    Giger Lab: 734 647 4966   3678 BSRB
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  • Nervous System Regeneration: Molecular Mechanisms that Limit Axonal Regeneration Following Spinal Cord Injury, Optic Nerve Injury and Multiple Sclerosis.
    Headshot of Ajit Joglekar

    Joglekar, Ajit 
  • Assistant Professor
  • Office: 734 764 2474  3067 BSRB
    Joglekar Lab: 734 764 7833   3818 BSRB
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  • Cellular Biophysics of macromolecular protein machines with in vivo and in vitro fluorescence microscopy techniques and biophysical analysis. Current focus is on the molecular mechanisms of kinetochore function and regulation during cell division.
    Headshot of Jiandie Lin

    Lin, Jiandie 
  • Associate Professor
  • Office: 734 615 3512  5437 LSI
    Lin Lab: 734 615 3510   5382 LSI
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  • Investigates the regulatory networks that control nutrient and energy metabolism, using integrated genomic, metabolomic, molecular, and mouse genetic tools. We are interested in exploring the pathogenic mechanisms underlying type 2 diabetes, cardiovascular disease, and non-alcoholic fatty liver disease, and their potential for therapeutic development.
    Headshot of Yukiko Yamashita

    Yamashita, Yukiko 
  • Assistant Professor
  • Office: 734 615 8508  5403 LSI
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  • Interested in understanding how stem cells utilize cell biological mechanisms, which are shared with most cell types, yet in a stem cell-specific way, to accomplish stem cells' function. We study how stem cells orient their division plane in the context of signaling microenvironment to divide asymmetrically, how such process is monitored, and how it changes during aging.

Joint Faculty

    Headshot of Maria Castro

    Castro, Maria 
  • Professor P: Neurosurgery
  • Office: 734 764 0850  4570 MSRB II
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  • Development of immunotherapies for primary and metastatic brain cancer: from basic immunobiology mechanisms to translational immune-therapeutics. Tumor immune-microenvironment: its role in tumor progression and response to therapeutics. Cross talk between cancer cells and hematopoietic stem/progenitor cells. Mechanisms affecting the migration of immune cells from peripheral lymphoid organs to the tumor microenvironment
    Headshot of William Dauer

    Dauer, William 
  • Associate Professor P: Neurology
  • Office: 734 615 5632  4003 BSRB
    Dauer Lab: 734 763 0616   4130 BSRB
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  • Molecular and cellular mechanisms of human neurological disease. Cell biological and animal model studies of neurodegeneration, especially in Parkinson's disease, and of primary dystonia,a related functional disease of the motor system.
    Headshot of Philip Gage

    Gage, Philip 
  • Associate Professor P: Ophthalmology & Visual Science
  • Office: 734 763 4215  3388 BSRB
    Gage Lab: 734 763 5699   350 KEC
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  • Genetic analysis of mammalian eye development; cell fate decisions in neural crest and mesoderm, transgenic mice, and gene targeted mice.
    Headshot of Jun-Lin Guan

    Guan, Jun-Lin 
  • Professor P: Internal Medicine: Molecular Medicine & Genetics
  • Office: 734 615 4936  5437 LSI
    Guan Lab: 734 615 4635   3027 BSRB
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  • Understand fundamental principles of cell signaling in the regulation of basic cellular functions and to determine how disruption of the normal signaling pathways either by genetic mutations or environmental insults may lead to disease
    Headshot of Gary Hammer

    Hammer, Gary 
  • Professor P: Internal Medicine
  • Office: 615-2421  1528 BSRB
    Hammer Lab: 763-6289   1860 BSRB
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  • Research projects are aimed at elucidating the mechanisms by which growth factor signaling and transcriptional programs initiate adrenal-specific growth and differentiation with an emphasis on dysregulated growth of adrenocortical stem/progenitor cells in development and cancer.
    Headshot of Cheng-Yu Lee

    Lee, Cheng-Yu 
  • Assistant Professor P: Internal Medicine: Molecular Medicine & Genetics
  • Office: 734 615 2793  5401 LSI
    Lee Lab: 734 615 5522   5183 LSI
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  • Understanding the molecular mechanisms by which newly identified fly genes regulate self-renewal vs. differentiation in fly neuroblasts.
    Headshot of Pedro Lowenstein

    Lowenstein, Pedro 
  • Professor P: Neurosurgery
  • Office:  4570 MSRB II
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  • The current focus of my research program is to discover the cellular, molecular, and mathematical basis underlying the growth patterns of malignant brain tumors, and the interactions between cancer cells with the tumor microenvironment, in both experimental models and in human patients suffering from malignant brain tumors.
    Headshot of Yuan Zhu

    Zhu, Yuan 
  • Associate Professor P: Internal Medicine: Molecular Medicine & Genetics
  • Office: 734 647 3033  2061 BSRB
    Zhu Lab: 734 647 0891   2688 BSRB
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  • Use of mouse genetics to understand the molecular and cellular mechanisms underlying the initiation and progression of tumor development.

Research Faculty

Emeritus Faculty

    Headshot of Pentti Jokelainen

    Jokelainen, Pentti 
  • Professor Emeritus
  • Office: 734 763 4499  6437 LSI
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  • Uses the yeast Saccharomyces cerevisiae to discover how cell structures are delivered to the right place at the right time, which informs understanding of embryonic development adn many diseases including cancer and diabetes.