Richard G. Ohye, M.D. - Research
Mitral Valve Repair Using the Da Vinci™ Surgical System
Investigators: Steven F. Bolling, MD, Richard L. Prager, MD, Richard G. Ohye, MD, Surgery
Funding: Intuitive Surgical, Inc.
In this study, safety and effectiveness of the da Vinci™ Surgical System and Endoscopic Instruments will be evaluated for repair of the mitral valve in subjects with significant mitral valve disease requiring surgical management.
Investigational Use of the Contregra Pulmonary Conduit Study 9202-99C
Investigators: Edward L. Bove, MD, Richard G. Ohye, MD, Surgery; and Caren Goldberg, MD, Pediatric Cardiology
Funding: VenPro Corporation / Medtronic, Inc
The optimal conduit for right ventricular outflow tract reconstruction in congenital heart disease has not yet been identified. A new conduit, harvested from bovine jugular vein, is being evaluated to assess its utility in patients requiring right ventricular to pulmonary artery conduit insertion.
Outcome of Infants with Functional Single Ventricle: Regional Cerebral Perfusion Versus Deep Hypothermic Circulatory Arrest
Investigators: Richard G. Ohye, MD, Surgery; and Caren S. Goldberg, MD, Pediatric Cardiology
Funding: Doris Duke Foundation
The current standard for the repair of complex congenital heart defects in children requiring aortic reconstruction includes the use of deep hypothermic circulatory arrest (DHCA). DHCA entails cooling the patient to 18°C and stopping all blood flow for a variable period of time. During this time, blood flow ceases to all vital organs, including the brain. Although the exact safe duration of DHCA is unknown, it is generally felt that 45-60 minutes is safe. While some studies have found few differences in the physical and mental development of children undergoing DHCA, others have found subtle changes in up to 50% of patients. Due to this uncertainty, several groups have described a new technique of regional cerebral perfusion (RCP) to supply blood to the brain during these periods, which would otherwise require DHCA. No study has shown any negative result from the use of RCP. Whether DHCA or RCP is better for the patient is currently unknown.
The goal of RCP is to maintain a supply of blood and oxygen to the brain throughout the case. Outcome will be assessed based on the patient's immediate post-operative and long-term neurological development and survival. In addition, RCP also appears to supply some blood flow to other organs in the body. Therefore, other outcomes such as heart function, kidney function, liver function, lung function, post-operative bleeding, time on the ventilator, length of stay in the ICU and length of hospital stay will also be monitored during the hospitalization.