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Cardioprotection Research Laboratory

Cardioprotection Research Laboratory

(website: sitemaker.umich.edu/cardiac.phytomed/research)

This laboratory investigates methods to protect the heart from ischemia/reperfusion injury. Ischemia/reperfusion damage can be severe and acute as during cardiac surgery procedures, or mild and chronic as with congestive heart failure or occlusive cardiovascular disease. Central to this damage is the generation of free radicals, which stimulate both local and systemic inflammation. We examine the impact of synthetic pharmaceuticals, natural phytochemicals, and dietary nutrients on several measures of cardiac function and viability following ischemia/reperfusion injury.