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Research

Research

In the University of Michigan Department of Cardiac Surgery, clinical investigators and basic researchers work together every day to develop deeper understanding and promising approaches to solving and treating heart disease.

Cardiac Surgery faculty have scientific interests in basic, translational and clinical research and are an integral part of the effort to establish premier cardiovascular research at University of Michigan. Our investigators are part of the first wave of investigators scheduled to reside within the cardiovascular research cluster under development at the new NCRC site at the University of Michigan. This cluster integrates outstanding research teams with diverse research interests and approaches. A key goal for this cluster is to develop and encourage discovery and innovation by fostering collaboration and cross-fertilization among investigators. Our faculty will serve as important anchors for heart failure and congenital heart research in this venture.

The overall research mission of Cardiac Surgery faculty is to advance the fight against cardiovascular disease. Basic research discoveries by our faculty have generated new insight into complex processes contributing to and responsible for heart disease. Faculty interests range from studies to understand motor and molecular switch proteins involved in regulating pump performance by the heart to genetic, environmental and dietary contributions to heart failure. Our investigators utilize a diverse array of approaches encompassing techniques ranging from molecular biology, genetics, and biophysics to whole organism physiology and sophisticated bioinformatic analysis of gene and protein expression in hearts. Advances in our understanding of heart function from these studies performed at the bench also are translated to the clinic by investigators on our faculty. Translational studies include the development of innovative drugs, devices, and clinical approaches for treating heart disease as well as participation in the groundbreaking clinical trials necessary to bring these advances to the bedside.

Faculty in University of Michigan Cardiac Surgery are active in research, seeking new treatments for and deeper understanding of cardiovascular disease.

Our research is providing fundamental insights into identifying methods to grow new heart muscle, identify natural phytochemicals and dietary nutrients to protect cardiac function, and study mechanical ventricular assist devices that provide a life-saving bridge to transplant. Through these endeavors – and many more like them – our researchers are working together to identify and implement real solutions for patients of today and tomorrow.

Learn about our research.