Gastrointestinal (GI) Cancer Research
Diane Simeone, M.D., co-director
The GI Oncology Research Program consists of 41 members from 18 departments who are supported by $9.4 million in annual direct funding. The members
have significant interactions with other programs in the Cancer Center including:
Judy Leopold, Ph.D., co-director
- Cancer Genetics
- Radiation Sciences
- Molecular Imaging
- Biomedical Prevention
- Cancer Cell Biology.
The central themes of the program are divided into disease sites that include pancreas, gastric, colorectal, and liver malignancies. Within the pancreas cancer theme, the goals of the members include: identification of molecular signals and markers of pancreatic cancer, development of new diagnostic tools for pancreas cancer and development of novel therapeutic options for pancreas cancer. Significant basic science investigations are being conducted in the areas of gastric and colorectal cancers. For gastric cancers, the goal has been focused upon the molecular events leading to carcinogenesis. This effort is supported through a program project grant that was awarded to members of the program during this past funding cycle. For colorectal cancers, the major goals have been focused upon investigations in molecular carcinogenesis, molecular epidemiology, and chemoprevention. Within the liver theme, a major effort of the program has been on the development of novel, early detection biomarkers, studies of the tumor microenvironment, and the enhanced use of regional therapies for primary and secondary malignancies
For more specific information about ongoing research Visit the Gastrointestinal Oncology SPORE.
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