Endocrine Oncology Program Research
Research on the genetics of adrenal cancer has two components; mouse studies and human studes (as explained below):
Adrenal Cancer Genetics
Mouse StudiesThese studies evaluate the role of adrenocartical stem cells in the development of adrenocartical tumors. Through a variety of genetic approaches, such as deleting or mutating a given gene in a mouse, or adding back a gene to a mouse - the effects of this genetic changes on adrenal growth are analyzed. These studies help identify genes that are dysregulated in adrenal cancer, and that will lead to direct biologic therapies. The preliminary testing is done with mice with the hope this will lead to human clinical trials.
These studies utilize the Michigan Endocrine Oncology Repository (MEOR) to correlate gene profiles with clinical data regarding:
1) tumor stage and grade, metastasis etc.
2) patient outcome data - how well patients responded
treatment; how long did remission last, etc.
Read about this on the Hammer Lab web site
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