Associate Professor, Department of Internal Medicine, Division of Nephrology
Subramaniam Pennathur, M.B.B.S., received his medical degree from Tirunelveli Medical College, Madurai University in India. He completed his residency in medicine at Barnes Hospital at Washington University School of Medicine and research fellowships at Massachusetts General Hospital and Harvard Medical School, and Washington University School of Medicine.
The central theme of Dr. Pennathur's research has focused on the applications of biological mass spectrometry in disease pathogenesis. A major focus of his lab has been to define the role of oxidative stress on disease pathogenesis and complications. They have utilized mass spectrometry to identify key protein and metabolite alterations in disease states and tested the hypothesis whether these alterations predict complications in animal models and humans. Dr. Pennathur's strategy has been to develop analytical techniques in animal models and validate these markers in humans and then interrogating the animal model for biological pathway relevance. Recent extension of this work has included targeted as well as unbiased metabolomic and proteomic profiling.