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Jérôme Kalifa, M.D, PH.D., Assistant Professor
Center for Arrhythmia Research

Research summary:

Dr. Jérôme Kalifa's research is dedicated to improving the understanding and treatment of cardiac arrhythmias at large. Specifically, his laboratory integrated into the Center for Arrhythmia Research is focused on the exploration of the mechanisms and pathophysiology of atrial fibrillation. Atrial fibrillation is the most common sustained arrhythmia in adults and affects millions on individuals throughout the world. While some patients are responsive to existing therapies, a large group of patients with atrial fibrillation undergo serious complications such as stroke or decompensated heart failure. Thus, improved preventive and therapeutic approaches are highly awaited. In his laboratory, Dr Jérôme Kalifa implements several experimental models enabling the exploration of atrial fibrillation mechanisms and therapeutics in various clinically-relevant settings such as: acute or chronic mechanical stretch, heart failure, persistent atrial fibrillation and atrial ischemia. In these models, innovative means of mapping the electrical impulse propagation in specific atrial areas, such as the posterior left atrium and the pulmonary veins, are employed. For example, endoscopic optical mapping and simultaneous endocardial-epicardial high resolution mapping give novel insights into the way that atrial impulses are propagating throughout the detailed atrial anatomy. These studies contribute to elucidate the mechanisms of atrial fibrillation initiation and maintenance and provide the basis for the development of novel therapeutic options.


Dr. Kalifa's publications are listed on PubMed. You can view them here.