Omer Berenfeld, Ph.D., Associate Professor of Internal Medicine and of Biomedical Engineering
Center for Arrhythmia Research
Our research focuses on mechanisms of wave propagation and fibrillation using a combination of experimental, clinical, and numerical approaches with the aim of better understanding of acute and chronic atrial fibrillation as well as ventricular fibrillation. Current projects in Dr. Berenfeld's laboratory include:
1. Dynamics of impulse propagation and reentrant activity. We investigate the basic effects of the ionic and structural properties of the heart on the normal and abnormal propagation of its action potential. As studies demonstrated that vortex-like reentrant propagation underlies some cases of cardiac arrhythmias we are using theoretical, numerical and experimental approaches to better understand the dynamics of such pattern of activation.
2. Mechanisms of atrial fibrillation. Analysis in the time, phase and frequency domains is used for mechanistic correlation of spatiotemporal activation patterns with the atrial substrate properties. Emphasis is given to the translation of knowledge derived from experimental and computational models into the clinical setting of patients with paroxysmal and chronic atrial fibrillation.
3. Biophysical mechanisms in two inherited cardiac diseases. Catecholaminergic polymorphic ventricular tachycardia and arrhythmogenic right ventricular dysplasia/cardiomyopathy involve calcium handling irregularity and non-myocytes infiltration with inter-cellular coupling disruption, respectively. Our research focuses on the fundamental biophysical mechanisms of arrhythmia in numerical and experimental models of these two diseases.
Dr. Berenfeld's publications are listed on PubMed. You can view them here.