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The Center for Arrhythmia Research began as the Institute for Cardiovascular Research (ICR) at SUNY Upstate Medical University in Syracuse, NY. The ICR was officially established in 2002, but was a world leader in the fight against cardiovascular diseases for decades prior.

In December, 2007, the ICR opted to leave SUNY to join the U-M Cardiovascular Center and help form new heart-rhythm center.