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Department of Anesthesiology- Research Division |
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Dr. Poe's research combines interests in basic sleep processes, development, learning and memory, and optimization of cognitive performance. Cutting edge techniques (multiple microelectrodes) are used to measure activity from 30-60 neurons (currently in the hippocampus) simultaneously in freely behaving animals. Dr. Poe's laboratory has located a neural discharge pattern that could explain why REM sleep is important to synaptic reorganization in general, which includes the synaptic changes that occur during learning and normal development. Detailed investigation of these neural processes should uncover the normal mechanisms underlying the role of sleep in learning and memory and explain cognitive declines that parallel REM sleep disruptions, such as in certain cases of mental retardation and in the normal aging process. Dr. Poe is currently funded by the National Institute of Mental Health to study REM sleep and memory. Dr. Poe serves as an ad hoc reviewer for grants and manuscripts in her field. Her teaching activities include lectures for several Neuroscience graduate courses and participation in the Undergraduate Research Opportunity Program at the University of Michigan. Recent Publications: Poe GR, Rector DM, and Harper RM. State-dependent columnar organization of dorsal hippocampal activity in the freely-behaving cat. Behavioral Brain Research 38(1):107-112, 2003. [PubMed] Kristensen MP, Rector DM, Poe GR, Harper RM. Activity changes of the cat paraventricular hypothalamus during stressor exposure. Neuroreport 15:43-8, 2004. [PubMed] Bjorness TE, Riley BT, Tysor MK, Poe GR. REM restriction persistently alters strategy used to solve a spatial task. Learning & Memory 12:352-359, 2005. [PubMed] Booth V, Poe GR. Input source and strength influences overall firing phase of model hippocampal CA1 pyramidal cells during theta: Relevance to REM sleep reactivation and memory consolidation. Hippocampus 2006; 16(2):161-73. [PubMed] Jablonski P, Poe GR, Zochowski M. Structural network heterogeneities and network dynamics: A possible dynamical mechanism for hippocampal memory reactivation - art. no. 011912. Physical Review E, 75 (1): 1912-1912 Part 1 Jan 2007. [PubMed] Best, J., Diniz Behn, C., Poe, G.R. and Booth, V. Neuronal models for sleep-wake regulation and synaptic reorganization in the sleeping hippocampus. J Biol Rhythms, 22:220-232, 2007.[PubMed] Research Divisions | ||||||
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