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Dr. Poe's research combines interests in basic sleep processes, development, learning and memory, and optimization of cognitive performance. Cutting edge techniques (multiple microelectrodes) are used to measure activity from 30-60 neurons (currently in the hippocampus) simultaneously in freely behaving animals. Dr. Poe's laboratory has located a neural discharge pattern that could explain why REM sleep is important to synaptic reorganization in general, which includes the synaptic changes that occur during learning and normal development. Detailed investigation of these neural processes should uncover the normal mechanisms underlying the role of sleep in learning and memory and explain cognitive declines that parallel REM sleep disruptions, such as in certain cases of mental retardation and in the normal aging process. Dr. Poe is currently funded by the National Institute of Mental Health to study REM sleep and memory.
Dr. Poe serves on the Learning and Memory study section of the NIH Center for Scientific Review, on the Senate Advisory Committee for University Affairs (SACUA), and on the Sleep Research Society's Board of Directors, in addition to reviewing manuscripts in her field and guiding students in research in her laboratory. Her teaching activities include lectures for Neuroscience and Physiology graduate courses, the Medical School 2nd year curriculum, a Physiology and Sleep undergraduate course, and participation in the Undergraduate Research Opportunities program at the University of Michigan.
Recent Publications:
Gross BA, Walsh CM, Turakhia AA, Booth V, Mashour GA, Poe GR. Open-source logic-based automated sleep scoring software using electrophysiological recordings in rats. J Neurosci Methods. 2009 Jul 15. [Epub ahead of print]
Wang JX, Poe G, Zochowski M. From network heterogeneities to familiarity detection and hippocampal memory management. Phys Rev E Stat Nonlin Soft Matter Phys. 2008 Oct; 78(4 Pt 1):041905. [PubMed]
Reasor JD, Poe GR. Learning and memory during sleep and anesthesia. Int Anesthesiol Clin. 2008; 46(3):105-29. [PubMed]
Best J, Diniz Behn C, Poe GR and Booth V. Neuronal models for sleep-wake regulation and synaptic reorganization in the sleeping hippocampus. J Biol Rhythms, 22:220-232, 2007.[PubMed]
Jablonski P, Poe GR, Zochowski M. Structural network heterogeneities and network dynamics: A possible dynamical mechanism for hippocampal memory reactivation - art. no. 011912. Physical Review E, 75 (1): 1912-1912 Part 1 Jan 2007. [PubMed]
Booth V, Poe GR. Input source and strength influences overall firing phase of model hippocampal
CA1 pyramidal cells during theta: Relevance to REM sleep reactivation and memory
consolidation. Hippocampus 2006; 16(2):161-73. [PubMed]
Bjorness TE, Riley BT, Tysor MK, Poe GR. REM restriction persistently alters strategy used to solve a spatial task. Learning & Memory 12:352-359, 2005. [PubMed]
Kristensen MP, Rector DM, Poe GR, Harper RM. Activity changes of the cat paraventricular hypothalamus during stressor exposure. Neuroreport 15:43-8, 2004. [PubMed]
Poe GR, Rector DM, and Harper RM. State-dependent columnar organization of dorsal hippocampal activity in the freely-behaving cat. Behavioral Brain Research 38(1):107-112, 2003. [PubMed]
Research Divisions |
