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Department of Anesthesiology- Research Division |
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Why do some live whereas others die in response to (seemingly) the same insult? What is the impact of systemic infection on sleep? Dr. Opp directs a research program funded by the National Institutes of Health to answer these, and other questions related to sleep-immune interactions. The central nervous system (CNS) has an extensive surveillance system to monitor the peripheral immune system. Responses to challenge, irrespective of the nature of the stimulus, almost invariably include changes in behavior. With respect to sleep-immune interactions, an unanswered fundamental question is whether the changes in sleep through the course of an infectious insult contribute to clinical outcome. Before such functional questions can be answered, a more complete understanding of mechanisms mediating sleep-immune interactions is necessary. To determine mechanisms by which immune challenge alters sleep, Dr. Opp’s research utilizes multiple techniques and focuses on actions of neuromodulatory molecules in the brain. Interactions among neuromodulatory molecules, (cytokines such as interleukin-1), and neurotransmitter systems (the serotonergic, GABAergic, cholinergic, and hypocretinergic systems) play a role in the regulation of natural sleep (National Institute of Mental Health), and mediate changes in sleep during sepsis (National Institute of General Medical Sciences; National Heart, Lung, and Blood Institute) and during viral infections (National Institute of Allergy and Infectious Disease). Recent Publications: Opp MR. Sleep and psychoneuroimmunology. Immunol Allergy Clin North Am. 2009 May; 29(2):295-307. [PubMed] Imeri, L., and M. R. Opp. How (and why) the immune system makes us sleep. Nature Reviews Neuroscience 10(3):199-210, 2009. [PubMed] Opp, M. R. Sleeping to fuel the immune system: mammalian sleep and resistance to parasites. BMC Evolutionary Biology 9:8, 2009. [PubMed] Morrow, J. D., S. Vikraman, L. Imeri, and M. R. Opp. Effects of serotonergic activation by 5-hydroxytryptophan on sleep and body temperature of C57BL/6J and interleukin-6-deficient mice are dose and time-related. SLEEP 31: 21-33, 2008. [PubMed] Olivadoti, M., and M. R.Opp. Effects of intracerebroventricular administration of interleukin (IL)-1 on sleep and body temperature of IL-6-deficient mice. Neuroscience 153: 338-348, 2008. [PubMed] Baracchi, F. and M. R. Opp. Sleep-wake behavior and responses to sleep deprivation of mice lacking both Interleukin-1b receptor 1 and Tumor Necrosis Factor-a receptor 1. Brain, Behav. Immunity 22: 982-993, 2008. [PubMed] Datta, S. C., and M. R. Opp. Lipopolysaccharide-induced alterations in multiple cytokines detected in discrete mouse brain regions using Luminex xMAP® technology. J. Neurosci. Methods 175: 119-124, 2008. [PubMed] Nemzek, J. A., K. M. S. Hugunin, and M. R. Opp. Modeling sepsis in the laboratory: merging sound science with animal well-being. Comp. Med. 58: 1-9, 2008. [PubMed] Olivadoti, M., L.A. Toth, J. Weinberg, and M.R. Opp. Murine gammaherpesvirsu-68: a model for the study of Epstein-Barr virus infections and related diseases. Comp. Med. 57: 44-50, 2007. [PubMed] Brambilla D., S. Franciosi, M. R. Opp and L. Imeri. Interleukin-1 inhibits firing of serotonergic neurons in the dorsal raphe nucleus and enhances GABAergic inhibitory post-synaptic potentials. Eur. J. Neurosci. 26: 1862-1869, 2007. [PubMed] Imeri, L., S. Bianchi and M. R. Opp. Inhibition of caspase-1 in rat brain reduces spontaneous non-rapid eye movement (NREM) sleep and NREM sleep enhancement induced by lipopolysaccharide. Am. J. Physiol. 291: R197-R204, 2006. [PubMed] Morrow, J. D. and M. R. Opp. Sleep-wake behavior and responses of interleukin-6-deficient mice to sleep deprivation. Brain Behav. Immunity 19: 28-39, 2005. [PubMed] Morrow, J. D. and M. R. Opp. Diurnal variation of lipopolysaccharide-induced alterations in sleep and body temperature of interleukin-6-deficient mice. Brain Behav. Immunity 19: 40-51, 2005. [PubMed] Baker, F. C., S. Shah, D. Stewart, C. Angara, H. Gong, R. Szymusiak, M. R. Opp and D. McGinty. Interleukin 1b enhances non-rapid eye movement sleep and increases c-Fos protein expression in the median preoptic nucleus of the hypothalamus. Am. J. Physiol. 288: R998-R1005, 2005. [PubMed] Imeri, L, S. Bianchi and M. R. Opp. Antagonism of corticotropin-releasing hormone alters serotonergic-induced changes in brain temperature, but not sleep of rats Am. J. Physiol. 289:R1116-R1123, 2005. [PubMed] Review papers and book chapters: Opp, M. R. Cytokines and sleep. Sleep Med. Rev. 9:355-364, 2005. Opp, M. R. Sleep and Psychoneuroimmunology. Neurol. Clin. 24: 493-506, 2006. Opp, M. R., J. Born, M. R. Irwin. Sleep and the Immune System. In: Psychoneuroimmunology, 4th Edition. Ader, R. (ed.). San Diego: Elsevier, pp. 539-578, 2007. Baracchi, F., and M. R. Opp. Cytokines, Immunity, and Sleep. In: The Neuroimmunological Basis of Behavior and Mental Disorders (http://www.springerlink.com/content/j383663uj5l51384/). Siegel and Zalcman (eds.). Springer Science+Business Media, LLC, New York. pp. 209-233, 2008. Research Divisions | ||||||
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