 |
 |
 |
|---|
| Home |
|---|
|
Department of Anesthesiology- Research Division |
||||||
The National Heart, Lung, and Blood Institute of the National Institutes of Health funds Dr. Lydic's laboratory. The goals of his research programs are to elucidate the mechanisms by which sleep, opioids, and volatile anesthetics depress breathing and arousal. The evolutionary perspective, and current data, supports the view that neurons generating sleep and wakefulness preferentially modulate the ability of opioids, hypnotics, and anesthetics to obtund wakefulness. This concept underlies work in Dr. Lydic's laboratory characterizing the neurochemical and signal transduction processes through which cholinergic neurons modulate sleep, arousal, and autonomic control. Recent work has shown that adenosine and nitric oxide modulate pontine acetylcholine release and arousal. A second research program is characterizing the effects of opioids on cholinergic neurotransmission. These studies aim to understand the cellular and molecular mechanisms by which opioids inhibit cholinergic neurotransmission and disrupt sleep and breathing. Both of these research programs encourage an active interaction between basic and clinical investigators. Recent Publications: Wang W, Baghdoyan HA, Lydic R. Leptin replacement restores supraspinal cholinergic antinociception in leptin-deficient obese mice. J Pain. 2009 Aug; 10(8):836-43. [PubMed] Van Dort CJ, Baghdoyan HA, and Lydic R. Adenosine A1 and A2A receptors in the prefrontal cortex modulate acetylcholine release and behavioral arousal. Journal of Neuroscience 29: 871-881, 2009. [PubMed] Hambrecht VS, Vlisides PE, Row BW, Gozal D, Baghdoyan HA, and Lydic R. G proteins in the prefrontal Cortex (PFC) of Sprague-Dawley rat are differentially activated as a function of oxygen status and PFC region. Journal of Chemical Neuroanatomy 37: 112-117, 2009. [PubMed] Vanini G, Watson CJ, Lydic R, Baghdoyan HA. Gamma-aminobutyric acid-mediated neurotransmission in the pontine reticular formation modulates hypnosis, immobility, and breathing during isoflurane anesthesia. Anesthesiology 109: 978-988, 2008. [PubMed] Geisser ME, Wang W, Smuck M, Koch LG, Britton SL, and Lydic R. Nociception before and after exercise in rats bred for high and low aerobic capacity. Neuroscience Letters 443: 37-40, 2008. [PubMed] Brummett CM, Norat MA, Palmisano JM, Lydic, R. Perineural administration of dexmedetomidine in combination with bupivacaine enhances sensory and motor blockade in sciatic nerve block without inducing neurotoxicity in rat. Anesthesiology 109: 502-511, 2008. [PubMed] Hambrecht VS, Vlisides PE, Row BW, Gozal D, Baghdoyan HA, and Lydic R. Hypoxia modulates cholinergic but not opioid activation of G proteins in rat hippocampus. Hippocampus 17: 934-942, 2007. [PubMed] Watson CJ, Lydic R, Baghdoyan HA. Sleep and GABA levels in the oral part of rat pontine reticular formation are decreased by local and systemic administration of morphine. Neuroscience 144:375-86, 2007. [PubMed] Lydic, R. Sleep disruption is related to allelic variation in the ob gene. Am J Physiol Regul Integr Comp Physiol 290:R892-893, 2006. [PubMed] Coleman CG, Baghdoyan HA, Lydic R. Dialysis delivery of an adenosine A2A agonist into the pontine reticular formation of C57BL/6J mouse increase pontine acetylcholine release and sleep. J Neurochem 96:1750-1759, 2006. [PubMed] Lydic R, Garza-Grande R, Struthers R, Baghdoyan HA. Nitric oxide in B6 mouse and nitric oxide-sensitive soluble guanylate cyclase in cat modulate acetylcholine release in pontine reticular formation. J Appl Physiol 100:1666-1673, 2006. [PubMed] Bernard R, Lydic R, Baghdoyan HA. Hypocretin (orexin) receptor subtypes differentially enhance acetylcholine release and activate G protein subtypes in rat pontine reticular formation. J Pharmacol Exp Ther 317:163-171, 2006. [PubMed] Osman NI, Baghdoyan HA, Lydic R. Morphine inhibits acetylcholine release in rat prefrontal cortex when delivered systemically or by microdialysis to basal forebrain. Anesthesiology 103: 779-87, 2005. [PubMed] Lydic R and Baghdoyan HA. Sleep, anesthesiology, and the neurobiology of arousal state control. Anesthesiology 103: 1268-95, 2005. [PubMed] Douglas CL, Bowman, GN, Baghdoyan HA, and Lydic R. C57BL/6J and B6.V-LEPOB mice differ in the cholinergic modulation of sleep and breathing. J App Physiol 98:918-929, 2005. [PubMed] Research Divisions | ||||||
|
| Contact the webmaster |