 |
 |
 |
|---|
| Home |
|---|
|
Department of Anesthesiology- Research Division |
||||||
Research Interests: * The interaction of the oral antiplatelet agent clopidogrel to the cholesterol lowering agent atorvastatin * The pharmacogenomic mechanism of clopidogrel resistance * How general anesthesia affects the severity of mitral regurgitation Current Projects: General Clinical Research Center (GCRC) award, University of Michigan. "The Inhibition of Platelet Antiaggregating Activity of Clopidogrel by Atorvastatin Detected by Erythromycin Breath Test: A Metabolic Inhibition of Hepatic Cytochrome P450-3A." Primary Investigator, March 1999 - present. Foundation for Anesthesia and Education Research (FAER) Grant. "Elucidation of the Molecular Mechanism by Which Atorvastatin (Liptor) Diminishes the Ability of Clopidogrel (Plavix) to Interfere with Platelet Aggregation." Primary investigator, 40% effort, July 2001- June 2002. Course Director for Intraoperative Transesophageal Echocardiography Seminars. 1999-present Recent Publications: Bates ER, Lau WC. Controversies in antiplatelet therapy for patients with cardiovascular disease. Circulation 111: E267-E271, 2005. [PubMed] Bates ER, Lau WC, Bleske BE. Loading, pretreatment, and interindividual variability issues with clopidogrel dosing. Circulation 111: 2557-2559, 2005. [PubMed] Gurbel PA, Lau WC, Bliden KP, Tantry US . Clopidogrel resistance: implications for coronary stenting. Curr Pharm Des. 2006;12(10):1261-9 . [PubMed] Lau WC, Gurbel PA. Antiplatelet Drug Resistance and Drug-Drug Interactions: Role of Cytochrome P450 3A4. Pharm Res. 23:2691-708, 2006. [PubMed] Eagle KA, Lau WC. Any need for preoperative cardiac testing in intermediate-risk patients with tight beta-adrenergic blockade? J Am Coll Cardiol. 2006 Sep 5;48(5):970-2. [PubMed] Michelson AD, Linden MD, Furman MI, Li Y, Barnard MR, Fox ML, Lau WC, McLaughlin TJ, Frelinger AL. Evidence that pre-existent variability in platelet response to ADP accounts for "clopidogrel resistance". J Thromb Haemost. 2007 5:75-81, 2007. [PubMed] Michelson AD, Furman MI, Lau WC, McLaughlin TJ, Frelinger AL 3rd. Evidence that pre-existent variability in platelet response to ADP accounts for "clopidogrel resistance": reply to a rebuttal. J Thromb Haemost. 2007 May; 5(5): 1089-90. [PubMed] Research Divisions | ||||||
|
| Contact the webmaster |