Currently Enrolling Studies
All MADC-supported studies are in need of volunteers, including people living with memory loss or dementia, caregivers, and healthy volunteers. Please complete the Research Volunteer Form or contact us at 734-936-8764 to learn more. List of supporting studies.
ADNI-2
PI: Judy Heidebrink, MD
Project description: Alzheimer’s Disease Neuroimaging Initiative Grand Opportunity. This longitudinal imaging study will look at the usefulness of brain imaging and other biological tests (biomarkers) in detecting Alzheimer’s disease and its progression. Information will be collected and stored in this study to help researchers design future studies to identify and treat Alzheimer’s disease at an early stage.
Participation criteria: Mild Cognitive Impairment and Alzheimer’s disease; over the age of 55. A study partner is required.
Contact: Joanne L. Lord, 734-647-7760, email: jllord@umich.edu
ADNI brochure
Wyeth/Pfizer 3000
PI: Nancy Barbas, MD, MSW
Project description: A Phase 3, multicenter, randomized, double-blind, placebo-controlled, parallel-group efficacy and safety trial of Bapineuzumab (AAB-001, ELN115727). In this protocol neither the subjects nor the investigators will know if they are receiving the actual medication. Bapineuzumab is an antibody, a type of protein usually produced by white blood cells to destroy other substances in the body. In Alzheimer’s disease a protein called amyloid gathers in the brain and is thought to cause symptoms like memory loss and confusion. The purpose of this research study will assess whether Bapineuzumab is safe, well-tolerated, and effective for use in subjects with Alzheimer’s disease. Bapineuzumab is an investigational drug and has not been approved for the treatment of Alzheimer’s disease. It is being tested to determine if Bapineuzumab will attach to and remove the amyloid protein. Participants will receive the study drug or a placebo on 6 separate occasions, once every 13 weeks, over a period of 65 weeks. Participants will be asked to return to the site for additional safety visits for 13 more weeks. Approximately 18-22 months in total.
Participation criteria: Mild to moderate Alzheimer’s disease
Contact: Joanne L. Lord, 734-647-7760, email: jllord@umich.edu
REVEAL (Risk Evaluation and Education for Alzheimer's Disease) Study
PI: Scott Roberts, PhD, Assistant Professor, Department of Health Behavior & Health Education, University of Michigan School of Public Health
Project Description: This study will explore the impact of incorporating genetic testing into a risk assessment program for individuals with Mild Cognitive Impairment (MCI). Participants will be randomized to one of two groups. Participants in the intervention group will receive risk information based on their age, the diagnosis of MCI and their APOE genotype, while participants in the comparison group will receive risk information based on their MCI diagnosis and age alone.
Participation criteria: Individuals diagnosed with amnestic-MCI, ages 55-90. A study partner is required (i.e. close friend, relative, or spouse).
Contact: Lan Q. Le, lqle@umich.edu, 734-615-2422 website: http://hbhegenetics.sph.umich.edu/
Study Brochure
Couples Life Story Project
PI: Berit-Ingersoll-Dayton, PhD, Professor, School of Social Work
Co-PI: Beth Spencer, LMSW, Silver Club Programs
Project description: During this project, participants will discuss their lives together as a couple and make a Couple Life Story Book. This process will be used to help couples think about positive memories and work on communication techniques.
Participation criteria: One person in the couple with memory loss; MMSE between 15-27
Contact: Beth Spencer, 734-764-2556
Investigation of Neuroanatomical Networks to Understand Late Onset Depression
PI: Scott Langenecker, PhD & Sara Wright, PhD
Project description: A study on healthy aging, Alzheimer's disease, and depression. Eligible participants may undergo neuropsychological testing and neurological exams, functional MRI, and positron emission tomography (PET) imaging. Participants will be paid $15 per hour for 1 - 4 sessions.
Participation criteria: Between the ages of 60 and 90
Contact: Dr. Scott Langenecker, 734-615-6144
Study brochure
The Role of Cognitive and Affective Variables in Explaining Increased Risk of Falls
PI: Sara Weisenbach, PhD
Project description: A mobility and depression study. Eligible participants may be tested on attention, memory, mobility, and undergo a structural MRI. Participants will be paid up to $90 for up to 6.5 hours over 1 - 3 visits.
Participation criteria: Over the age of 60; difficulty with balance or recurrent falls
Contact: Dr. Sara Wright, 734-936-3180
Effects of an Alert Maintenance Task on Driving Performances: A Simulation Study
PI: Bruno Giordani, PhD
co-PI: Carol Persad, PhD
Project description: This study involves the use of a computerized driving simulator to find out if engaging in a simple game-like task could promote alertness and improved driving performance in fatigued older drivers. The study will take place in 2 separate sessions that will last approximately 2 hours each. Participants will be compensated for their time spent in the study.
Participation criteria: Over the age of 55; valid driver’s license over the past 2 years and driving in past 6 months.
Contact: Carol Cline (734) 232-0128 cdcline@med.umich.edu
FEOBV investigational PET tracer study
PI: Kirk Frey, PhD and Myria Petrou
Project Description: New investigational study looking at vesicular ACh transporter intended to provide initial evidence for possible further development. Study will initially look at normal controls undergoing PET scanning (completed).
Participation criteria: Patients with DLB, PDD and possibly AD or related disorders to undergo PET scanning, brain MRI and memory testing.
Contact: Kris Wernette, 734-936-5894 email: krisw@umich.edu
Information on Alzheimer's disease studies can also be found on the University of Michigan Clinical Studies website.
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