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Marina A. Grachtchouk, PhD

Assistant Research Scientist, Department of Dermatology

Selected Publications

  1. Grachtchouk M, Mo R, Yu S, Zhang X, Sasaki H, Hui CC, and Dlugosz AA. Basal cell carcinomas in mice overexpressing Gli2 in skin. Nat Genet. 2000;24:216-217.
  2. Sheng H, Goich S, Wang A, Grachtchouk M, Lowe L, Mo R, Lin K, de Sauvage FJ, Sasaki H, Hui CC, and Dlugosz AA. Dissecting the oncogenic potential of Gli2 in skin: Deletion of an NH2-terminal fragment alters tumor phenotype. Cancer Res. 2002;62:5308-5316.
  3. Mill P, Mo R, Fu H, Grachtchouk M, Kim PCW, Dlugosz AA, and Hui CC. Sonic hedgehog-dependent activation of Gli2 is essential for embryonic hair follicle development. Genes Dev. 2003;17:282-294.
  4. Grachtchouk V*, Grachtchouk M*, Lowe L, Johnson TJ, Wei L, Wang A, de Sauvage F, and Dlugosz AA. The magnitude of hedgehog signaling activity defines skin tumor phenotype. EMBO J. 2003;22:2741-2751 (* equal contribution).
  5. Allen M, Grachtchouk M, Sheng H, Grachtchouk V, Wang A, Wei L, Liu J, Ramirez A, Metzger D, Chambon P, Jorcano J, Dlugosz AA. Hedgehog signaling regulates sebaceous gland development. Am J Pathol. 2003;163:2173-2178.
  6. Cui C, Elsam T, Tian Q, Seykora JT, Grachtchouk M, Dlugosz A and Tseng H. Gli proteins up-regulate the expression of basonuclin in Basal Cell Carcinoma. Cancer Res. 2004;64:5651-5658.
  7. Brancaccio A, Minichiello A, Grachtchouk M, Antonini D, Sheng H, Pariato R, Dathan N, Dlugosz AA and Missero C. Requirement of the forkhead gene Foxe1, a target of sonic hedgehog signaling, in hair follicle morphogenesis. Hum Mol Genet. 2004;13:2595-2606.
  8. Hutchin ME, Kariapper MST, Grachtchouk M, Wang A, Wei L, Cummings D, Liu J, Michael LE, Glick A, Dlugosz AA. Sustained Hedgehog signaling is required for basal cell carcinoma proliferation and survival: conditional skin tumorigenesis recapitulates the hair growth cycle. Genes & Dev. 2005;19:214-223.
  9. Roessler E, Ermilov AN, Grange DK, Wang A, Grachtchouk M, Dlugosz AA, Muenke M. A previously unidentified amino-terminal domain regulates transcriptional activity of wild-type and disease-associated human GLI2. Hum Mol Genet. 2005;14:2181-2188.
  10. Grachtchouk M, Liu J, Wang A, Wei L, Bichakjian C, Garlick J, Paulino A, Giordano T, Dlugosz A. Odontogenic keratocysts arise from quiescent epithelial rests and are associate with deregulated Hedgehog signaling in mice and humans. Am J Pathol. September 2006;169(3):806-814.
  11. Dentice M, Luongo C, Huang S, Ambrosio R, Elefante A, Mirebeau-Prunier D, Zavacki AM, Fenzi G, Grachtchouk M, Hutchin M, Dlugosz AA, Bianco AC, Missero C, Larsen PR, Salvatore D. Sonic hedgehog-induced type 3 deiodinase blocks thyroid hormone action enhancing proliferation of normal and malignant keratinocytes. Proc Natl Acad Sci USA Sept 4, 2007;104(36):14466-14471. Epub 2007 Aug 24.


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