This information is approved and/or reviewed by U-M Health System providers but it is not a tool for self-diagnosis or a substitute for medical treatment. You should speak to your physician or make an appointment to be seen if you have questions or concerns about this information or your medical condition. Exención de responsabilidad en Español | Complete disclaimer
Cystic fibrosis (CF) is a birth defect that causes the body to produce thick, sticky mucus. Usually, mucus is thin and slippery. In cystic fibrosis, the thick mucus causes lung infections and blocks the lungs. This is especially dangerous if it blocks airways and breathing stops. These thick secretions may block the pancreas, which helps the intestines to break down and absorb food. The mucus also can block the bile duct in the liver and cause permanent liver damage over time.
CF can affect all races and ethnic groups, but occurs mostly in whites. It affects people in different ways and by varying degrees.
CF is caused by defective genes that are passed from parent to child. A child must inherit a defective CF gene from each parent to have CF. If the child only gets one CF gene, he or she is a carrier of the disease, but does not have it. If both parents have the cystic fibrosis gene, there is a 25% chance that each child they have will have CF.
Newborns with cystic fibrosis may develop a blocked intestine the first day or two after birth. Other signs in newborns include failure to grow, bulky foul-smelling greasy stools, and frequent respiratory infections.
Common symptoms of cystic fibrosis in children and young adults include:
Additional signs may include delayed growth, enlargement or rounding of the fingertips and toes, liver problems, on-going diarrhea, abdominal swelling, part of the rectum coming out of the anus, or a collapsed lung.
Most states test for cystic fibrosis as part of newborn screening. Even though most newborn screens that suggest CF are false positive tests, a positive on this test means a higher chance that your child has the disease. CF is usually diagnosed by age 3, but it can be much later for those who have a mild case.
If your child's newborn screen suggests that he or she may have CF, your child should have a sweat test. The sweat test measures the amount of salt in your child's sweat. People with CF have a high level of salt in their sweat. To do the test, a special chemical is put on part of the skin to help make your child sweat. An electrode is put on the area and weak electrical current causes the area to sweat. The sweat is collected and tested in a lab. The test does not hurt.
There is no cure for cystic fibrosis. The goal of treatment is to help your child lead as normal a life as possible and slow down the progress of the disease. The average lifespan for someone with CF is about 37 years. Treatment for CF may include taking medicine such as:
Your child may also need to eat more calories to help fight infection. For a baby this may mean making high-calorie breast milk or formula. For a toddler or older child, you will need to add extra calories during the day. Using more dairy products is an easy way to add calories (for example, you can give your child whole milk, use extra butter on foods, or add extra cheese to pizza or casseroles). You will also need to learn chest physical therapy (CPT). CPT helps drain your child's airways by tapping on your child's chest or back. You will need to do this at least twice a day.
Your child may also need to:
For more information about CF, contact:
The Cystic Fibrosis Foundation
Web Site: http://www.cff.org
The National Heart, Lung, and Blood Institute
Web Site:
http://www.nhlbi.nih.gov/health/dci/Diseases/cf/cf_what.html
