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Herbal Medicines Reported to Have Effects on Coagulation

 

Herbal Medicine Propsed Mechanism Drug Interactions
Alfalfa Contains coumarin constituents ?
Angelica Contains coumarin constituents ?
Aniseed Contains coumarin constituents ?
Asafoetida Contains coumarin constituents ?
Celery Contains coumarin constituents ?
Chamomille Contains coumarin constituents Large doses may interfere with anticoagulant therapy
Clove Inhibits platelet activity May interact with anticoagulants or antiplatelet drugs to increase risk of bleeding
Dong Quai ? May interact with anticoagulants or antiplatelet drugs to increase risk of bleeding
Echinacea ? Increases bleeding time (but not INR) has been reported in patients on long-term warfarin therapy
Evening Primrose Oil Inhibits platelet aggregation May interact with anticoagulants or antiplatelet drugs to increase risk of bleeding
Feugreek Contains coumarin constituents ?
Fever Few Inhibits platelet aggregation May interact with anticoagulants or antiplatelet drugs to increase risk of bleeding
Garlic Inhibits platelet aggregation May interact with anticoagulants or antiplatelet drugs to increase risk of bleeding
Ginger Inhibits platelet aggregation May interact with anticoagulants or antiplatelet drugs to increase risk of bleeding
Gingko biloba Inhibits platelet aggregation May interact with anticoagulants or antiplatelet drugs to increase risk of bleeding
Ginseng, Panax Inhibits platelet aggregation May interact with anticoagulants or antiplatelet drugs to increase risk of bleeding
Goldenseal ? May interact with warfarin
Horse Chestnut Contains coumarin constituents May interact with anticoagulants or antiplatelet drugs to increase risk of bleeding
Kava Kava Inhibits platelet aggregation May interact with anticoagulants or antiplatelet drugs to increase risk of bleeding
Licorice Inhibits platelet activity May interact with anticoagulants or antiplatelet drugs to increase risk of bleeding
Meadowsweet Contains salicylate constituents Same precautions as with salicylates may be warranted
Poplar Contains salicylate constituents Same precautions as with salicylates may be warranted
Prickly Ash, Northern Contains coumarin constituents ?
Prickly Ash, Southern Contains coumarin constituents ?
Quassia Contains coumarin constituents ?
Red Clover Contains coumarin constituents ?
White Willow/Willow Bark Contains salicylate constituents Same precautions as with salicylates may be warranted

Julie Golembiewski, Pharm. D., University of Michigan Health System